Monoclonal gammopathy in chronic myeloproliferative disorders

Abstract

The incidence of monoclonal gammopathy in 61 patients with chronic myeloproliferative disorders (CMPD) was studied. The distribution of patients among the CMPD subgroups was: chronic myelocytic leukemia, 24 patients; myelofibrosis, 11; polycythemia vera, 15; essential thrombocythemia, 7; unclassified MPD, 4 patients. Monoclonal gammopathy was found in 5 patients (8.2%). Two of these patients (1 IgA/k and 1 IgM/k) had myelofibrosis and 3 (2 IgG/k and 1 IgG/lambda) polycythemia vera. The presence of monoclonal gammopathy indicates an involvement of the lymphoplasmatic system in CMPD.

Coexistence of Myeloproliferative Neoplasm and Plasma-Cell Dyscrasia

“…In a prospective study conducted in 61 MPN patients (median age 62 y) in Greece from 1982 to 1987 by Economopoulos et al, 26 8.2% (n ¼ 5) of patients were found to have coexisting MGUS, which is higher than the prevalence reported in the general population at approximately 1% to 3%. 27,28 Of these 61 patients, 37 had a Philadelphia chromosome-negative MPN (15 PV; 7 ET; 11 MF; 4 unclassifiable); 24 patients had chronic myeloid leukemia (CML).…”

Development of multiple myeloma after 15 years of treatment for polycythemia vera and successful treatment using bortezomib: A case report

“…MPN including PV have also been associated with monoclonal gammopathy 17–20 . Economopoulos et al 17 reported monoclonal gammopathy in 8.2% out of 61 patients with MPNs. Randi et al 18 and Javorniczky et al 20 reported these rates to be 3.1% and 9% of cases, respectively, identifying higher rates in such patients than those in age‐ and sex‐matched controls; however, these results were not statistically significant.…”

Precision Medicine in BCR-ABL1 Negative Myeloproliferative Neoplasms

“…In 3-14% of MPN patients, a monoclonal gammopathy can be identified [38][39][40][41] , probably coincidentally 39 though one study has reported its presence to be associate with an adverse MPN disease course. 41…”