Monoclonal gammopathy of renal significance: Multidisciplinary approach to diagnosis and treatment

Karam, Sabine; Haidous, Mohammad; Dalle, Iman Abou; Dendooven, Amélie; Moukalled, Nour; Craenenbroeck, Amaryllis H. Van; Bazarbachi, Ali; Sprangers, Ben

doi:10.1016/j.critrevonc.2023.103926

Cited by 5 publications

(2 citation statements)

References 135 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, due to the edema of both lower limbs and proteinuria, the patient was easily misdiagnosed as having MGRS. MGRS is a spectrum of disorders in which renal injury is caused by M proteins secreted by benign or precancerous clonal B cells or plasma cells (8). By definition, this category does not meet the diagnostic criteria for multiple myeloma (MM) and WM and is used to describe patients who otherwise meet the diagnostic criteria for MGUS but who have M protein-induced kidney injury.…”

Section: Discussionmentioning

confidence: 99%

Case report: Waldenstrom macroglobulinemia with systemic amyloidosis as the main manifestation

Yin,

Zhou,

et al. 2024

Front. Med.

View full text Add to dashboard Cite

Systemic amyloidosis is a rare protein misfolding and deposition disorder leading to progressive organ failure. Waldenström macroglobulinemia (WM) with systemic amyloidosis as the main manifestation is even rarer. The patient in this study presented with recurrent diarrhea and had not been diagnosed in other hospitals on multiple occasions. Later, his diarrhea worsened and was accompanied by sunken edema of both lower limbs and dizziness. Renal biopsy showed deposits of PAS light-staining material in the glomeruli, interstitium, and small arteries, which stained positively with Congo red. Cardiac ultrasound showed interventricular septum thickening of 17 mm, right ventricular wall myocardial thickening of approximately 0.6 cm, and septal thickening of approximately 0.5 cm, considering myocardial amyloidosis. Electromyography showed abnormal peripheral nerve conduction. Lymphoplasmacytic cells were found in the bone marrow. Taken together, he was diagnosed with WM. He was treated with a BR (Bendamustine + Rituximab) regimen. After 6 courses, the patient’s discomfort was relieved, his weight gained 5 kg, the level of serum IgM and dFLC decreased, and cardiac and renal assessments were more relieved. The patient has been followed up for more than 1 month.

show abstract

Section: Discussionmentioning

confidence: 99%

Case report: Waldenstrom macroglobulinemia with systemic amyloidosis as the main manifestation

Yin,

Zhou,

et al. 2024

Front. Med.

View full text Add to dashboard Cite

show abstract

“…While hematological changes in MGRS lesions resemble those in MGUS lesions, the presence of MIg in MGRS lesions can lead to kidney damage. Unlike MGUS lesions, initiating treatment for most MGRS cases upon diagnosis is crucial to prevent further kidney damage 2 . Therefore, determining whether renal injury is associated with MIg holds considerable importance for treatment decisions and patient prognosis assessments.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a diagnostic nomogram model for predicting monoclonal gammopathy of renal significance

Dong,

Yan,

Zhang

et al. 2024

Sci Rep

View full text Add to dashboard Cite

In patients with kidney disease, the presence of monoclonal gammopathy necessitates the exploration of potential causal relationships. Therefore, in this study, we aimed to address this concern by developing a nomogram model for the early diagnosis of monoclonal gammopathy of renal significance (MGRS). Univariate and multivariate logistic regression analyses were employed to identify risk factors for MGRS. Verification and evaluation of the nomogram model's differentiation, calibration, and clinical value were conducted using the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis. The study encompassed 347 patients who underwent kidney biopsy, among whom 116 patients (33.4%) were diagnosed with MGRS and 231 (66.6%) with monoclonal gammopathy of undetermined significance. Monoclonal Ig-related amyloidosis (n = 86) and membranous nephropathy (n = 86) was the most common renal pathological type in each group. Notably, older age, abnormal serum-free light chain ratio, and the absence of microscopic hematuria were identified as independent prognostic factors for MGRS. The areas under the ROC curves for the training and verification sets were 0.848 and 0.880, respectively. In conclusion, the nomogram model demonstrated high accuracy and clinical applicability for diagnosing MGRS, potentially serving as a valuable tool for noninvasive early MGRS diagnosis.

show abstract

Monoklonale Gammopathie renaler Signifikanz (MGRS)

Hegenbart,

Beimler,

Schönland

2024

Nephrologie

View full text Add to dashboard Cite

Monoclonal gammopathy of renal significance: Multidisciplinary approach to diagnosis and treatment

Cited by 5 publications

References 135 publications

Case report: Waldenstrom macroglobulinemia with systemic amyloidosis as the main manifestation

Case report: Waldenstrom macroglobulinemia with systemic amyloidosis as the main manifestation

Development and validation of a diagnostic nomogram model for predicting monoclonal gammopathy of renal significance

Monoklonale Gammopathie renaler Signifikanz (MGRS)

Contact Info

Product

Resources

About