Monoclonal gammopathy of undetermined significance in pediatric kidney transplant: A possible role of Epstein‐Barr virus

Abstract

MG is a common event of hematologic malignancies. There are many papers regarding kidney transplantation patients with MGUS in adults, while data in pediatrics are scarce. The etiology and clinical significance of MGUS are unclear both in adults and children. Immunosuppressive drugs, graft antigenicity, and viral infection could play a possible role. The viruses most frequently implicated seem to be EBV or CMV in particular, but their role has to be defined better. However, many investigators have emphasized an impaired balance between an adequate immune response and reactivation of viral infection.

Neoplastic and non‐neoplastic complications of solid organ transplantation in patients with preexisting monoclonal gammopathy of undetermined significance

“…Solid organ transplant requires long‐term use of immunosuppression post‐engraftment, which is associated with many risks overlapping those described above, including hematologic malignancies and post‐transplant lymphoproliferative disease (PTLD), opportunistic infections, SRE, and VTE. MGUS‐affected patients usually are not excluded from transplantation; however, data on long‐term outcomes are lacking and limited to single institution studies with relatively small patient numbers . We hypothesized that patients with the precancerous condition, MGUS, are at heightened risk for these post‐transplant complications.…”