Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study

Kristinsson, Sigurður Y.; Tang, Min; Pfeiffer, Ruth M.; Björkholm, Magnus; Goldin, Lynn R.; Blimark, Cecilie; Mellqvist, Ulf‐Henrik; Wåhlin, Anders; Turesson, Ingemar; Landgren, Ola

doi:10.3324/haematol.2011.054015

Cited by 122 publications

(117 citation statements)

References 25 publications

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“…8 Recent studies have showed an increased risk of infections in patients with monoclonal gammopathy of undetermined significance (MGUS), highlighting the contribution of the underlying plasma cell disorder to the immunodeficiency. 9,10 It has also been shown that multiple myeloma patients display a low immune response to infections and vaccines, and that it also predicted a higher risk of infection. 11,12 In addition to the inherent immunodeficiency, some small studies have described a changing spectrum of infections in MM, possibly related to the more intensive treatment approach of recent years, suggesting that the novel agents may increase the risk of infections in MM patients.…”

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confidence: 99%

Multiple myeloma and infections: a population-based study on 9253 multiple myeloma patients

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Multiple myeloma and infections: a population-based study on 9253 multiple myeloma patients

et al. 2014

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“…A recent Swedish study of MM and infection showed an increased risk of pneumonia, with a hazard ratio (HR) of 7.7 compared to matched population-based controls (6). Kristinsson et al found an increased risk of pneumonia in MGUS patients, with a HR of 2.4 (4).…”

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confidence: 99%

“…atients with multiple myeloma (MM) and other clonal B cell disorders such as Waldenstrom's macroglobulinemia (WM) and monoclonal gammopathy of undetermined significance (MGUS) are at increased risk of contracting and succumbing to pneumococcal infections (1)(2)(3)(4). In a study of invasive pneumococcal disease, the attack rate in MM patients was 674 cases/ 100,000 per year compared to 11 cases/100,000 per year in an population of adults Ն18 years of age (odds ratio [OR], 62.8) (5).…”

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confidence: 99%

Poor Correlation between Pneumococcal IgG and IgM Titers and Opsonophagocytic Activity in Vaccinated Patients with Multiple Myeloma and Waldenstrom's Macroglobulinemia

Karlsson

Roalfe

Hogevik

et al. 2016

Clin Vaccine Immunol

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e Patients with multiple myeloma and other B cell disorders respond poorly to pneumococcal vaccination. Vaccine responsiveness is commonly determined by measuring pneumococcal serotype-specific antibodies by enzyme-linked immunosorbent assay (ELISA), by a functional opsonophagocytosis assay (OPA), or by both assays. We compared the two methods in vaccinated elderly patients with multiple myeloma, Waldenstrom's macroglobulinemia, and monoclonal gammopathy of undetermined significance (MGUS). Postvaccination sera from 45 patients (n ‫؍‬ 15 from each patient group) and 15 control subjects were analyzed by multiplexed OPA for pneumococcal serotypes 4, 6B, 14, and 23F, and the results were compared to IgG and IgM antibody titers measured by ELISA. While there were significant correlations between pneumococcal OPA and IgG titers for all serotypes among the control subjects (correlation coefficients [r] between 0.51 and 0.85), no significant correlations were seen for any of the investigated serotypes in the myeloma group (r ‫؍‬ ؊0.18 to 0.21) or in the group with Waldenstrom's macroglobulinemia (borderline significant correlations for 2 of 4 serotypes). The MGUS group resembled the control group by having good agreement between the two test methods for 3 of 4 serotypes (r ‫؍‬ 0.53 to 0.80). Pneumococcal postvaccination IgM titers were very low in the myeloma patients compared to the other groups and did not correlate with the OPA results. To summarize, our data indicate that ELISA measurements may overestimate antipneumococcal immunity in elderly subjects with B cell malignancies and that a functional antibody test should be used specifically for myeloma and Waldenstrom's macroglobulinemia patients.

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“…Es indispensable realizar un apropiado diferencial entre esta enfermedad y otras entidades similares con componente monoclonal IgM asociado como Gammapatía Monoclonal de Significado Incierto, Mieloma Múltiple, Leucemia Linfocítica Crónica, Linfomas No Hodgkin y trastornos en ausencia de infiltrado medular por Linfoma Lifoplasmocítico [9,33,34].…”

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“…Pese a lo anterior, desde hace varios años se ha llegado al consenso de no indicar tratamiento a los pacientes con GMSI ó con MW asintomática (smolderingó indolente), sólo se les efectúa un minucioso seguimiento cada 3 que éstos permanecen estables durante años [32,33,34,35].…”

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Macroglobulinemia De Waldenström: Caso Clínico Y Actualización

Quirós

Castrillo

2013

Rev.Med.UCR

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Resumen: La Macroglobulinemia de caracteriza por una infiltración medular de linfocitos relacionados clonalmente, que secretan una proteína monoclonal de tipo IgM. Según la clasificación de la O corresponde a un Linfoma No Hodgkin con mayor frecuencia en la población mayor de 65 años y particularmente, en varones caucásicos. Es indispensable realizar un apropiado diagnóstico dif similares con componente monoclonal asociado. factores genéticos y familiares. Se presenta el caso clínico de un paciente afecto de Waldenström sintomático agresivo con cuadro clínico de hemorragia retiniana y crioaglutininas, más otros signos ocasionados por la enfermedad. Palabras clave:Macroglobulinemia de

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Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study

Cited by 122 publications

References 25 publications

Multiple myeloma and infections: a population-based study on 9253 multiple myeloma patients

Multiple myeloma and infections: a population-based study on 9253 multiple myeloma patients

Poor Correlation between Pneumococcal IgG and IgM Titers and Opsonophagocytic Activity in Vaccinated Patients with Multiple Myeloma and Waldenstrom's Macroglobulinemia

Macroglobulinemia De Waldenström: Caso Clínico Y Actualización

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