Monoclonal immunoglobulins in patients with carcinoma of the colon

Wang, A. C.; Tung, E.; Wang, I.; Fudenberg, H. Hugh; Pick, Adi; Froehlichman, R.

doi:10.1007/bf00199533

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…Such ob servations, in conjunction with the frequent occurrence of antitumor antibodies in tumor patients [11,23], point to a possible rela tionship between M components and antitu mor antibodies in at least some cancer pa tients. In our previous studies, we found that M components in patients with carci noma of the colon have more structural similarity among themselves than with other unrelated monoclonal immunoglobulins [30,31], In the present study, we obtained simi lar results for M components in patients with another kind of solid tumor, TCC.…”

Section: Discussionsupporting

confidence: 65%

“…The existence of M components in some patients with solid tumors has long been known [1,12,18,22,25,29,31]. Such ob servations, in conjunction with the frequent occurrence of antitumor antibodies in tumor patients [11,23], point to a possible rela tionship between M components and antitu mor antibodies in at least some cancer pa tients.…”

Section: Discussionmentioning

confidence: 99%

“…Heavy (H) and light (L) chains of the M com ponents were prepared essentially as described previously by us [31],…”

Section: Preparation Of Heavy and Light Chainsmentioning

confidence: 99%

“…In our own studies, we have found an unusually high incidence (between 16 and 23%) of M components in TCC patients [25,31]. This has led us to examine the physicochemical properties of such proteins to see whether they are related to the antitu mor antibodies in TCC patients.…”

Section: Introductionmentioning

confidence: 99%

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Serological and Biochemical Analyses of M Components in Patients with Transitional Cell Carcinoma of the Urinary Bladder

et al. 1982

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Serological and biochemical studies were performed on M components isolated from 3 patients with transitional cell carcinoma of the urinary bladder (TCC). All were IgG1(K) proteins. 2 of the 3 belonged to the V_KI subgroup, and these 2 also possessed cross-reactive idiotypic determinants. These findings are consistent with the ideas that M components in patients with a given kind of cancer may have restricted heterogeneity, and that the synthesis of an M component and the manifestation of a solid tumor may be related events in some patients who exhibit both abnormalities.

show abstract

Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

“…Heavy (H) and light (L) chains of the M com ponents were prepared essentially as described previously by us [31],…”

Section: Preparation Of Heavy and Light Chainsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serological and Biochemical Analyses of M Components in Patients with Transitional Cell Carcinoma of the Urinary Bladder

et al. 1982

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“…The Cy regions of human IgG molecules are divided into four subclasses (Cy,, Cy2, Cy3, and C,4) encoded by distinct germ-line genes (1). Protein sequence studies (2)(3)(4)(5) have shown that the subclasses are highly homologous, indicating that the corresponding genes derive from a common ancestral Cy gene.…”

mentioning

confidence: 99%

Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes.

Ellison¹,

Hood²

1982

Proc. Natl. Acad. Sci. U.S.A.

109

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We report the nucleotide sequence of a gene encoding a human immunoglobulin Cy,2 region. Comparison with the previously determined C,,4 sequence reveals that these two genes share extensive (=95%) homology in the three CH domain exons and adjacent noncoding regions. In contrast, hinge exons have diverged to a much greater degree, implying that natural selection has favored the generation ofdiversity in these coding regions. We have used the .noncoding nucleotide differences to estimate that approximately 6-7 millionyears have elapsed since the occurrence of the gene duplication or correction event which generated the two identical ancestral genes. In addition we show that the two C,, genes are arranged in human chromosomal DNA in the configuration 5'-C,2-17 kilobase pairs -C,,4-3'.

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Distribution of immunoglobulins and secretory component in gastric cancer of the aged

Takemura

Hirokawa

Esaki

et al. 1990

Cancer

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The secretory immune system plays an important role in the local humoral immunity of the gastrointestinal tract. In order to evaluate humoral immunity in gastric cancer, distribution of immunoglobulins (Ig) and secretory component was immunohistochemically studied in 74 early and 15 advanced primary gastric cancers. In non-cancerous gastric mucosa, IgA and IgM, and secretory component were mainly identified in the cytoplasm of the intestinal metaplasia. In early gastric cancer of well-differentiated type, the localization of IgA and IgM, and secretory component was similar to that of intestinal metaplasia. In advanced gastric cancer, they were faintly observed and showed low positivity. The number of Ig-containing cells infiltrating cancerous stroma was enumerated. Immunoglobulin A-containing cells were dominant in the stroma of early gastric cancer. On the other hand, there were few Ig-containing cells in the stroma of advanced gastric cancer, and the number of IgA-containing and IgM-containing cells was also decreased. These results suggest that local humoral immunity is suppressed in gastric cancer, especially in advanced gastric cancer.

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Monoclonal immunoglobulins in patients with carcinoma of the colon

Cited by 5 publications

References 32 publications

Serological and Biochemical Analyses of M Components in Patients with Transitional Cell Carcinoma of the Urinary Bladder

Serological and Biochemical Analyses of M Components in Patients with Transitional Cell Carcinoma of the Urinary Bladder

Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes.

Distribution of immunoglobulins and secretory component in gastric cancer of the aged

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