1978
DOI: 10.1152/jappl.1978.45.6.962
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Monocrotaline model of noncardiogenic pulmonary edema in dogs

Abstract: Monocrotaline, a plant alkaloid shown histologically to produce pulmonary endothelial damage and edema, was used in dogs to produce an acute model of noncardiogenic pulmonary edema. Following intravenous injection there was no change in pulmonary vascular pressures or heart rate; cardiac output fell and pulmonary vascular resistance increased. After 2 h measurement of lung water demonstrated modest pulmonary edema in all animals. The degree of edema produced was more consistent and reproducible than that follo… Show more

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Cited by 29 publications
(6 citation statements)
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“…The used rat model has been extensively studied and biochemically, physiologically and histo-pathologically characterized by our group [10,15,16,20]. It is of particular interest in experimental studies on pulmonary hypertension and right ventricular heart failure [2,15,17,20,24,33], but it may also help to understand some human fetal pathological conditions associated to progressive heart failure and growth restriction, characterized by left and right ventricular increased afterload, progressing to right heart failure, with tricuspid valve failure and abnormal ductus venosus blood flow [25]. This conforms with the increasing interest of pre and post natal medicine regarding linear and non-linear HR analysis [1,5,12,13,29,34,35].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The used rat model has been extensively studied and biochemically, physiologically and histo-pathologically characterized by our group [10,15,16,20]. It is of particular interest in experimental studies on pulmonary hypertension and right ventricular heart failure [2,15,17,20,24,33], but it may also help to understand some human fetal pathological conditions associated to progressive heart failure and growth restriction, characterized by left and right ventricular increased afterload, progressing to right heart failure, with tricuspid valve failure and abnormal ductus venosus blood flow [25]. This conforms with the increasing interest of pre and post natal medicine regarding linear and non-linear HR analysis [1,5,12,13,29,34,35].…”
Section: Discussionmentioning
confidence: 99%
“…It is used to produce an acute model of non-cardiogenic pulmonary edema and a chronic model of cardiac failure associated to pulmonary hypertension with increased right ventricular end-systolic and end-diastolic volumes arising even under non-failing conditions [17,24]. A direct cardiotoxic effect, associated with myocarditis and coronary arteriolar medial thickening, has also been described and may further account for a depression of ventricular function [2].…”
Section: Introductionmentioning
confidence: 99%
“…or subcutaneous injection of monocrotaline. Observations included ultra-structural changes in the endothelial cells of the alveolar capillaries, of microvascular leak in the alveolar wall and interstitial oedema (Valdivia et al, 1967a,b;Miller et al,1978). …”
Section: Acute Toxicitymentioning
confidence: 99%
“…The most abundant sources of PAs are in the Asteraceae, Boraginaceae, Fabaceae, and Orchidaceae families (1) with many of the PAs toxic to humans as well as animals (2)(3)(4). Monocrotaline (MCT) induces a pulmonary vascular syndrome at low doses in rats (5,6), dogs (7), and monkeys (8) that is used as a model to study the pathogenesis of human primary pulmonary hypertension (9,10).…”
Section: Introductionmentioning
confidence: 99%