The paper deals with monocular image-based sense and avoid assuming constant aircraft velocities and straight flight paths. From very limited two dimensional image information it finally characterizes the whole three dimensional collision situation by estimating the time to closest point of approach, the horizontal relative distance and its direction and the vertical relative distance also. The distances are relative to the intruder aircraft horizontal and vertical sizes. The overall estimated relative distance is the closest between the two aircraft in three dimension. So finally, every important information can be extracted to be used in a collision decision. The applicability of the developed method is presented in software-in-the-loop simulation test runs. Several intruder size and speed values are considered together with trajectories covering the whole three dimensional space. The horizontal intruder flight directions relative to the own aircraft cover Systems and Control Laboratory, MTA SZTAKI, H-1111 Budapest, Kende utca 13-17.