Monocyclic β-lactam antibiotics produced by bacteria

Sykes, R. B.; Cimarusti, Christopher M.; Bonner, Daniel P.; Bush, Karen; Floyd, David M.; Georgopapadakou, Nafsika H.; Koster, William H.; Liu, W. C.; Parker, W.; Principe, Pacifico A.; Rathnum, Marlene L.; Slusarchyk, William A.; Trejo, William H.; Wells, John G.

doi:10.1038/291489a0

Cited by 306 publications

(104 citation statements)

References 9 publications

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“…Carbapenems are P-lactam antibiotics, discovered in the 1970s through a mass screening of micro-organisms for new antibiotics (Sykes et al, 1981;Imada et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

A pheromone-independent CarR protein controls carbapenem antibiotic synthesis in the opportunistic human pathogen Serratia marcescens

et al. 1998

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Strain ATCC 39006 of Serratia marcescens makes the same carbapenem, (5R)-carbapen-2-em-3-carboxylic acid (Car), as the Erwinia carotovora strain G S l O l .Unlike E. carotovora, where the onset of production occurs in the lateexponential phase of growth in response to the accumulation of the small diffusible pheromone N-(3~oxohexanoyl)-~-homoserine lactone (OHHL), in 5. marcescens carbapenem is produced throughout the growth phase and does not appear to involve any diffusible pheromone molecule. Two cosmids capable of restoring antibiotic production in E. carotovora group I carbapenem mutants were isolated from an 5. marcescens gene library. These cosmids were shown to contain a homologue of the E. carotovora carR gene, encoding a CarR protein with homology to the LuxR family of transcriptional regulators. The S. marcescens carR was subcloned and shown to be capable of complementing in trans, in the absence of OHHL, an E. carotovora carR car/ double mutant, releasing the heterologous E. carotovora host from pheromone dependence for carbapenem production. The apparent OHHL-independence of the S. marcescens CarR explains the constitutive nature of carbapenem production in this strain of 5. marcescens.

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“…Carbapenems are P-lactam antibiotics, discovered in the 1970s through a mass screening of micro-organisms for new antibiotics (Sykes et al, 1981;Imada et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

A pheromone-independent CarR protein controls carbapenem antibiotic synthesis in the opportunistic human pathogen Serratia marcescens

et al. 1998

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“…Aztreonam, a monobactam (17), has excellent activity against aerobic gram-negative bacteria, especially Enterobacteriaceae (4,16) and Pseudomonas aeruginosa (2,9). Because of its lack of activity against gram-positive and anaerobic organisms, it will likely be used with other agents in the initial therapy of serious infections in appropriate pediatric patients, such as newborns and immunocompromised and post-surgical patients.…”

mentioning

confidence: 99%

In vitro antimicrobial activity of aztreonam alone and in combination against bacterial isolates from pediatric patients

Stutman¹,

Welch²,

Scribner³

et al. 1984

Antimicrob Agents Chemother

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“…Aztreonam is a new monocyclic /Mactam antibiotic (Sykes et al, 1981) with high activity against aerobic Gram-negative bacteria. Previous studies have shown that aztreonam is eliminated predominantly through the kidneys and that its serum half-life is about 1 -6-1 -9 h (Swabb et al, 1982a, b, c, Wise et al, 1982.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics, in-vitro activity, therapeutic efficacy and clinical safety of aztreonam vs. cefotaxime in the treatment of complicated urinary tract infections

Naber

Dette

Kees³

et al. 1986

J Antimicrob Chemother

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Monocyclic β-lactam antibiotics produced by bacteria

Cited by 306 publications

References 9 publications

A pheromone-independent CarR protein controls carbapenem antibiotic synthesis in the opportunistic human pathogen Serratia marcescens

A pheromone-independent CarR protein controls carbapenem antibiotic synthesis in the opportunistic human pathogen Serratia marcescens

In vitro antimicrobial activity of aztreonam alone and in combination against bacterial isolates from pediatric patients

Pharmacokinetics, in-vitro activity, therapeutic efficacy and clinical safety of aztreonam vs. cefotaxime in the treatment of complicated urinary tract infections

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