Monocyte Adhesion to Decidual Endothelial Cells Is Increased in Pregnancies Complicated by Type 1 Diabetes but not by Gestational Diabetes

Galettis, Anoula; Campbell, Suzanne; Morris, Jonathan M.; Jackson, Chris; Twigg, S; Gallery, Eileen D.M.

doi:10.2337/diacare.27.10.2514

Cited by 6 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, women with T1DM experience fewer livebirths (Lin et al 2018), higher early pregnancy terminations (Sjöberg et al 2017) and a greater risk for preterm births (Ludvigsson et al 2019) than the general population. Increased infiltration and adhesion of monocytes to placental bed endothelium leading to inflammation and reduction of placental blood flow have been suggested to partly underlie these poor birth outcomes in women (Galettis et al 2004) and were mechanistically confirmed in non-obese diabetic mice (Burke et al 2007).…”

Section: Compromised Reproductive Healthmentioning

confidence: 88%

Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus

Simmen

Brown

Quick

et al. 2019

Journal of Endocrinology

View full text Add to dashboard Cite

Type 1 diabetes mellitus and endometriosis separately affect millions of women worldwide. Reproductive-age women diagnosed with type 1 diabetes may also suffer from endometriosis, but the asymptomatic pre-clinical period of highly variable duration for each condition can lead to challenges in the timely recognition of co-morbid disease onset and misdiagnosis. While knowledge of the pathogenesis of each condition has grown substantially, co-morbid endometriosis and type 1 diabetes has not been widely considered and much less addressed. This review discusses the molecular rationale for the likelihood of their co-existence, and prospects for improvements in therapeutic strategies and reduced complications, if this paradigm is included as a significant variable in disease management.

show abstract

Section: Compromised Reproductive Healthmentioning

confidence: 88%

Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus

Simmen

Brown

Quick

et al. 2019

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…We have previously shown increased adhesiveness of monocytes derived from women with T1DM to normal DEC [8], an abnormality not explicable simply by impaired glucose tolerance, as it was not seen in women with gestational diabetes. The novel results presented here now support a significant role for the decidual endothelium in the placental bed pathology of T1DM.…”

Section: Discussionmentioning

confidence: 99%

“…We have previously reported increased adherence of monocytes from pregnant diabetic subjects to normal decidual endothelial cells (DEC) [8]. Using the same in vitro co-culture system approach, this study now investigates adhesion of normal monocytes to DEC derived from pregnancies complicated by type 1 diabetes, and the role of ICAM-1 and VCAM-1 in this adhesion.…”

Section: Introductionmentioning

confidence: 99%

Intercellular adhesion molecule‐1 (ICAM‐1) expression is necessary for monocyte adhesion to the placental bed endothelium and is increased in type 1 diabetic human pregnancy

Xie

Galettis

Morris

et al. 2007

Diabetes Metabolism Res

Self Cite

View full text Add to dashboard Cite

show abstract

Current literature in diabetes

2005

Diabetes Metabolism Res

View full text Add to dashboard Cite

In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 26 sections: 1 Reviews & Symposia; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Obesity; 7 Prediction and Prevention; 8 Intervention: a) General; b) Care; c) Drug Therapy; d)Economics; e) Gene therapy; f) Nursing; g) Nutrition; h) Surgery; i) Transplantation; 9 Pathology and Complications: a) General; b) Cardiovascular; c) Eye disease; d) Gestational and fetal; e) Neurological; f) Podiatrical; g) Renal; 10 Endocrinology & Metabolism; 11 Experimental Studies; 12 Diagnosis and Techniques. Within each section, articles are listed in alphabetical order with respect to author (8 Weeks journals ‐ Search completed at 30th Mar 2005)

show abstract

Monocyte Adhesion to Decidual Endothelial Cells Is Increased in Pregnancies Complicated by Type 1 Diabetes but not by Gestational Diabetes

Cited by 6 publications

References 10 publications

Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus

Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus

Intercellular adhesion molecule‐1 (ICAM‐1) expression is necessary for monocyte adhesion to the placental bed endothelium and is increased in type 1 diabetic human pregnancy

Current literature in diabetes

Contact Info

Product

Resources

About