Monocyte and Macrophage Function Diversity

Kloc, Małgorzata; Kubiak, Jacek Z.

doi:10.3390/ijms232012404

Cited by 7 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Macrophages are an inherent cell subset of the immune system, first proposed in the late 19th century by Elie Metchnikov, who described them as a group of immune cells devoted to phagocytosis (Metschnikoff, 1891). Macrophages play an important role in maintaining tissue homeostasis and promoting tissue repair by not only removing apoptotic cells and foreign or pathogenic substances through phagocytosis, but also by secreting a range of cytokines to form a pro-or anti-inflammatory microenvironment (Nobs and Kopf, 2021;Kloc and Kubiak, 2022). Macrophages are derived from monocytes, which are derived from precursor hematopoietic stem cells in the bone marrow.…”

Section: Biology Of Macrophagesmentioning

confidence: 99%

Macrophages—bone marrow mesenchymal stem cells crosstalk in bone healing

Fan

Sun

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Bone healing is associated with many orthopedic conditions, including fractures and osteonecrosis, arthritis, metabolic bone disease, tumors and periprosthetic particle-associated osteolysis. How to effectively promote bone healing has become a keen topic for researchers. The role of macrophages and bone marrow mesenchymal stem cells (BMSCs) in bone healing has gradually come to light with the development of the concept of osteoimmunity. Their interaction regulates the balance between inflammation and regeneration, and when the inflammatory response is over-excited, attenuated, or disturbed, it results in the failure of bone healing. Therefore, an in-depth understanding of the function of macrophages and bone marrow mesenchymal stem cells in bone regeneration and the relationship between the two could provide new directions to promote bone healing. This paper reviews the role of macrophages and bone marrow mesenchymal stem cells in bone healing and the mechanism and significance of their interaction. Several new therapeutic ideas for regulating the inflammatory response in bone healing by targeting macrophages and bone marrow mesenchymal stem cells crosstalk are also discussed.

show abstract

Section: Biology Of Macrophagesmentioning

confidence: 99%

Macrophages—bone marrow mesenchymal stem cells crosstalk in bone healing

Fan

Sun

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

Macrophage plasticity: signaling pathways, tissue repair, and regeneration

Yan,

Wang,

Cai

et al. 2024

MedComm

View full text Add to dashboard Cite

Macrophages are versatile immune cells with remarkable plasticity, enabling them to adapt to diverse tissue microenvironments and perform various functions. Traditionally categorized into classically activated (M1) and alternatively activated (M2) phenotypes, recent advances have revealed a spectrum of macrophage activation states that extend beyond this dichotomy. The complex interplay of signaling pathways, transcriptional regulators, and epigenetic modifications orchestrates macrophage polarization, allowing them to respond to various stimuli dynamically. Here, we provide a comprehensive overview of the signaling cascades governing macrophage plasticity, focusing on the roles of Toll‐like receptors, signal transducer and activator of transcription proteins, nuclear receptors, and microRNAs. We also discuss the emerging concepts of macrophage metabolic reprogramming and trained immunity, contributing to their functional adaptability. Macrophage plasticity plays a pivotal role in tissue repair and regeneration, with macrophages coordinating inflammation, angiogenesis, and matrix remodeling to restore tissue homeostasis. By harnessing the potential of macrophage plasticity, novel therapeutic strategies targeting macrophage polarization could be developed for various diseases, including chronic wounds, fibrotic disorders, and inflammatory conditions. Ultimately, a deeper understanding of the molecular mechanisms underpinning macrophage plasticity will pave the way for innovative regenerative medicine and tissue engineering approaches.

show abstract