Monocyte and macrophage heterogeneity and Toll-like receptors in the lung

Schneberger, David; Aharonson-Raz, Karin; Singh, Baljit

doi:10.1007/s00441-010-1032-2

Cited by 80 publications

(57 citation statements)

References 131 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Only the thin alveolar wall separates alveolar from interstitial macrophages, which occupy the same narrow interalveolar space as alveolar capillaries, fibroblasts and other mesenchymal cells. Interstitial macrophages are thought to have roles in tissue remodeling and maintenance as well as antigen presentation (Aguzzi et al, 2013;Higashi et al, 1992;Lichanska and Hume, 2000;Robinson, 1984;Schneberger et al, 2011;Takeya and Takahashi, 1992), and influencing dendritic cell functions to prevent airway allergy (Bedoret et al, 2009;Ginhoux et al, 2010;den Haan and Kraal, 2012;Shibata et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Developmental origin of lung macrophage diversity

2016

View full text Add to dashboard Cite

Macrophages are specialized phagocytic cells, present in all tissues, which engulf and digest pathogens, infected and dying cells, and debris, and can recruit and regulate other immune cells and the inflammatory response and aid in tissue repair. Macrophage subpopulations play distinct roles in these processes and in disease, and are typically recognized by differences in marker expression, immune function, or tissue of residency. Although macrophage subpopulations in the brain have been found to have distinct developmental origins, the extent to which development contributes to macrophage diversity between tissues and within tissues is not well understood. Here, we investigate the development and maintenance of mouse lung macrophages by marker expression patterns, genetic lineage tracing and parabiosis. We show that macrophages populate the lung in three developmental waves, each giving rise to a distinct lineage. These lineages express different markers, reside in different locations, renew in different ways, and show little or no interconversion. Thus, development contributes significantly to lung macrophage diversity and targets each lineage to a different anatomical domain.

show abstract

Section: Introductionmentioning

confidence: 99%

Developmental origin of lung macrophage diversity

2016

View full text Add to dashboard Cite

show abstract

“…Alveolar macrophages also release transforming growth factor (TGF)-β, which inhibits immune responses by preventing dendritic cell-mediated activation of effector T-cells [4,14,15]. In addition, alveolar macrophages express several scavenger receptors that bind complement, damage-associated molecular pattern molecules, pathogen-associated molecular pattern molecules and immunoglobulins to facilitate pathogen clearance [2,16].…”

mentioning

confidence: 99%

The heterogeneity of lung macrophages in the susceptibility to disease

et al. 2015

View full text Add to dashboard Cite

Alveolar macrophages are specialised resident phagocytes in the alveolus, constituting the first line of immune cellular defence in the lung. As the lung microenvironment is challenged and remodelled by inhaled pathogens and air particles, so is the alveolar macrophage pool altered by signals that maintain and/or replace its composition. The signals that induce the recruitment of circulating monocytes to the injured lung, as well as their distinct gene expression profile and susceptibility to epigenetic reprogramming by the local environment remain unclear. In this review, we summarise the unique characteristics of the alveolar macrophage pool ontogeny, phenotypic heterogeneity and plasticity during homeostasis, tissue injury and normal ageing. We also discuss new evidence arising from recent studies where investigators described how the epigenetic landscape drives the specific gene expression profile of alveolar macrophages. Altogether, new analysis of macrophages by means of "omic" technologies will allow us to identify key pathways by which these cells contribute to the development and resolution of lung disease in both mice and humans. @ERSpublications Alveolar macrophages: the influence of ontogeny and microenvironment on epigenetically programmed responses to stress http://ow.ly/Owei1

show abstract

“…Although monocyte-derived macrophages are in general a good model to study macrophage behaviour, previous studies have shown that these cellular subsets in vitro might not always represents alveolar macrophages in vivo [8,50]. Therefore, theoretically it is still possible that alveolar macrophages are a source of polymers within the lung in vivo, although the levels secreted by MM alveolar macrophages are comparable with monocytes and monocyte-derived macrophages in vitro [8,42].…”

Section: Discussionmentioning

confidence: 91%

Function of monocytes and monocyte-derived macrophages in α₁-antitrypsin deficiency

et al. 2014

View full text Add to dashboard Cite

α 1 -antitrypsin deficiency is the most widely recognised genetic disorder causing chronic obstructive pulmonary disease (COPD). Mutant Z α 1 -antitrypsin expression has previously been linked to intracellular accumulation and polymerisation of this proteinase inhibitor. Subsequently, this has been described to underlie an exaggerated endoplasmic reticulum stress response and enhanced nuclear factor-κB signalling. However, whether monocyte-derived macrophages display the same features remains unknown.Monocytes from homozygous PiZZ α 1 -antitrypsin deficiency patients and PiMM controls were cultured for 6 days in the presence of granulocyte-macrophage or macrophage colony-stimulating factor to obtain pro-and anti-inflammatory macrophages (mw-1 and mw-2, respectively).We first showed that, in contrast to monocytes, pre-stressed mw-1 and mw-2 from healthy blood donors display an enhanced endoplasmic reticulum stress response upon a lipopolysaccharide trigger (XBP1 splicing, CHOP, GADD34 and GRP78 mRNA). However, this endoplasmic reticulum stress response did not differ between monocyte-derived macrophages and monocytes from ZZ patients compared to MM controls. Furthermore, these ZZ cells do not secrete higher cytokine levels, and α 1 -antitrypsin polymers were not detectable by ELISA.These data suggest that monocyte-derived macrophages are not the local source of Z α 1 -antitrypsin polymers found in the lung and that endoplasmic reticulum stress and pro-inflammatory cytokine release is not altered. @ERSpublicationsNo evidence for polymer formation and excess inflammatory responses in mononuclear phagocytes from AATD patients

show abstract

Monocyte and macrophage heterogeneity and Toll-like receptors in the lung

Cited by 80 publications

References 131 publications

Developmental origin of lung macrophage diversity

Developmental origin of lung macrophage diversity

The heterogeneity of lung macrophages in the susceptibility to disease

Function of monocytes and monocyte-derived macrophages in α₁-antitrypsin deficiency

Contact Info

Product

Resources

About

Monocyte and macrophage heterogeneity and Toll-like receptors in the lung

Cited by 80 publications

References 131 publications

Developmental origin of lung macrophage diversity

Developmental origin of lung macrophage diversity

The heterogeneity of lung macrophages in the susceptibility to disease

Function of monocytes and monocyte-derived macrophages in α1-antitrypsin deficiency

Contact Info

Product

Resources

About

Function of monocytes and monocyte-derived macrophages in α₁-antitrypsin deficiency