Monocyte chemoattractant protein-1 and paraoxonase-1 and 3 levels in patients with sepsis treated in an intensive care unit: a preliminary report

Sans, Teresa; Rull, Anna; Luna, José D.; Mackness, Bharti; Mackness, Michael I.; Joven, Jorge; Ibañez, M.; Pariente, R; Rodríguez, M. Mar; Ortı́n, Xavier; Masdeu, G.; Camps, Jordi

doi:10.1515/cclm-2011-0896

Cited by 25 publications

(23 citation statements)

References 33 publications

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“…In our study PON1 activities were lower in patients with higher APACHE II and SOFA scores. Our data are in contrast with results from Novak et al who did not find statistically significant correlation between PON1 activities and disease severity scores [20], while Sans et al found this correlation to be significant only after recovery from sepsis [21]. …”

Section: Discussioncontrasting

confidence: 99%

“…We have also found that both POase and DZOase activity were lower in surgical patients with sepsis than in healthy controls. In the study of Sans et al, POase activity significantly decreased between admission to ICU and the following day but remained unchanged for the next 4 days [21]. In our study, low PON1 activity did not significantly change during first 5 days of disease.…”

Section: Discussionsupporting

confidence: 45%

“…Various research groups have demonstrated that inflammation modulates PON1 activity [5]. Association between CPR and PON1 values in sepsis was observed by Novak et al [20] but not by Sans et al [21]. …”

Section: Discussionmentioning

confidence: 99%

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Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis

et al. 2014

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Introduction. State of severe oxidative stress is encountered in sepsis. Paraoxonase 1 (PON1) protects against oxidative stress but also undergoes inactivation upon that condition. We investigated PON1 activity in surgical patients with sepsis in relation to oxidative stress status, inflammation, disease severity, and survival. Methods. Prospective observational study. Sixty-nine surgical patients with sepsis were compared to 69 age/sex matched healthy controls. PON1 paraoxonase and diazoxonase activities, selected biochemical, hematological and oxidative stress parameters were measured on admission to ICU and 24, 48, 72, and 96 hours later. Disease severity scores were calculated daily. Results. Septic patients had significantly lower PON1 activities compared to control group at all time points. PON1 activities had good capacity to differentiate septic patients from healthy controls. Low PON1 activities were associated with higher disease severity scores and higher risk of death. Correlation between PON1 activity and markers of inflammation failed to reach significance. Decrease in PON1 activity was correlated with an increase in reducing components in plasma. Conclusion. Our study demonstrated lower PON1 activity in surgical patients with sepsis compared to healthy controls. PON1 activity also reflected severity of the disease. Low PON1 activity was associated with higher mortality of surgical patients with sepsis.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 45%

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Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis

et al. 2014

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“…However, there is a paucity of information on alterations in plasma CCL2 concentrations in infectious diseases. Recent studies reported that CCL2 levels are elevated in patients admitted to Intensive Care with sepsis, and in patients carrying an indwelling central venous catheter [9,29]. Results from the present investigation conclude that this is also the case in patients carrying an indwelling urinary catheter.…”

Section: Discussionsupporting

confidence: 75%

Preliminary study on serum paraoxonase-1 status and chemokine (C-C motif) ligand 2 in hospitalized elderly patients with catheter-associated asymptomatic bacteriuria

Iftimie

García-Heredia

Pujol

et al. 2016

Eur J Clin Microbiol Infect Dis

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Urinary tract infections (UTI) are common among elderly patients in residential care facilities, as well as in the hospital setting. Identifying new biochemical markers of UTI is an active line of research since UTI management is resource intensive. Paraoxonase-1 (PON1) forms part of the patient's immune system, the response-to-injury and inflammation. Our study sought to evaluate alterations in inflammation-related paraoxonase-1 (PON1) and chemokine (C-C motif) ligand 2 (CCL2) in patients with an indwelling catheter to assess their potential usefulness as biomarkers of infection. Patients (n = 142) who had had the urinary catheter removed and 100 healthy volunteers were recruited. In all participants we measured serum PON1 activity, PON1 concentration, CCL2, procalcitonin and C-reactive protein (CRP). Results indicated that patients had higher CCL2, CRP and procalcitonin concentrations than the control group, and lower paraoxonase activity. There were no significant differences in PON1 concentrations. When comparing the diagnostic accuracy of CRP, procalcitonin, CCL2 and the PON1-related variables in discriminating between patients with and those without UTI, we found a considerable degree of overlap between groups, i.e., a low diagnostic accuracy. However, there were significant inverse logarithmic correlations between serum paraoxonase activity and the number of days the urinary catheter had been in situ. Our results suggest that measurement of these biochemical variables may be useful in investigating complications of long-term use of these devices and help to improve the economic and clinical investment required in the management of the often-associated infection.

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“…Again, the combined regimen clearly exceeded the effect obtained by single inhibition of CD14 ), indicating the advantage of the combined regimen as compared to single inhibition of CD14. The attenuating effect on MCP-1 also implicates a possible clinical relevance as the level of this chemokine appears to be positively related to severity of sepsis (Sans et al 2012).…”

Section: Discussionmentioning

confidence: 89%

Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14

Egge

Thorgersen²,

Pischke

et al. 2015

Immunobiology

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Monocyte chemoattractant protein-1 and paraoxonase-1 and 3 levels in patients with sepsis treated in an intensive care unit: a preliminary report

Abstract: We observed an inverse pattern between changes in MCP-1, and PON1 and PON3 levels in patients with sepsis, this was related to the resolution of their infection after receiving treatment in an ICU.

Cited by 25 publications

References 33 publications

Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis

Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis

Preliminary study on serum paraoxonase-1 status and chemokine (C-C motif) ligand 2 in hospitalized elderly patients with catheter-associated asymptomatic bacteriuria

Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14

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