Monocyte chemoattractant protein-1 and the kidney

Haller, Hermann; Bertram, Anna; Nadrowitz, Felix; Menne, Jan

doi:10.1097/mnh.0000000000000186

Cited by 157 publications

(144 citation statements)

References 80 publications

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“…Indeed, MCP-1 was not associated with moderate to severe IFTA by univariate analysis, and a weaker discriminator of moderate to severe IFTA by ROC analysis. The lack of a strong predictive role for IFTA may reflect a more direct role of MCP-1 on macrophage infiltration and glomerular proliferation than on tubulointerstitial fibrosis as observed in some previous studies [9,24].…”

Section: Discussionmentioning

confidence: 82%

“…MCP-1 plays a major role in renal diseases progression through multiple processes beyond monocyte/macrophage recruitment [9,10]. Targeted inhibition of MCP-1 led to reductions in interstitial fibrosis and renal disease progression in experimental models [22,23].…”

Section: Discussionmentioning

confidence: 99%

“…Monocyte chemoattractant protein-1 (MCP-1) is a potent chemokine that promotes recruitment of inflammatory cells such as monocyte/macrophage into the kidney and contribute to tubulointerstitial involvement by promoting the release of several mediators including transforming growth factor-beta and [9,10]. Increased urinary excretion of MCP-1 have been observed in various glomerular diseases with correlations observed between urinary levels and degree of tubulointerstitial involvement [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Urine Epidermal Growth Factor, Monocyte Chemoattractant Protein-1 or Their Ratio as Biomarkers for Interstitial Fibrosis and Tubular Atrophy in Primary Glomerulonephritis

Worawichawong

Radinahamed

et al. 2016

Kidney Blood Press Res

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Background/Aims: The degree of tubular atrophy and interstitial fibrosis (IFTA) is an important prognostic factor in glomerulonephritis. Imbalance between pro-inflammatory cytokines such as monocyte chemoattractant protein-1 (MCP-1) and protective cytokines such as epidermal growth factor (EGF) likely determine IFTA severity. In separate studies, elevated MCP-1 and decreased EGF have been shown to be associated with IFTA severity. In this study, we aim to evaluate the predictive value of urinary EGF/MCP-1 ratio compared to each biomarker individually for moderate to severe IFTA in primary glomerulonephritis (GN). Methods: Urine samples were collected at biopsy from primary GN (IgA nephropathy, focal and segmental glomerulosclerosis, minimal change disease, membranous nephropathy). MCP-1 and EGF were analyzed by enzyme-linked immunosorbent assay. Results: EGF, MCP-1 and EGF/MCP-1 ratio from primary GN, all correlated with IFTA (n=58). By univariate analysis, glomerular filtration rate, EGF, and EGF/MCP-1 ratio were associated with IFTA. By multivariate analysis, only EGF/ MCP-1 ratio was independently associated with IFTA. EGF/MCP-1 ratio had a sensitivity of 88% and specificity of 74 % for IFTA. EGF/MCP-1 had good discrimination for IFTA (AUC=0.85), but the improvement over EGF alone was not significant. Conclusion: EGF/MCP-1 ratio is independently associated IFTA severity in primary glomerulonephritis, but the ability of EGF/ MCP-1 ratio to discriminate moderate to severe IFTA may not be much better than EGF alone.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Urine Epidermal Growth Factor, Monocyte Chemoattractant Protein-1 or Their Ratio as Biomarkers for Interstitial Fibrosis and Tubular Atrophy in Primary Glomerulonephritis

Worawichawong

Radinahamed

et al. 2016

Kidney Blood Press Res

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“…In our ongoing coculture studies, including monocytes, those cytokines will be also examined. Noteworthy, the selective inhibition of MCP-1 has been proven to reduce macrophage accumulation and renal injury 29–31 . The increased HGF production by EC may act in a paracrine fashion on adjacent PO, that in turn lack HGF expression, as shown here by our group and others 32 .…”

Section: Discussionmentioning

confidence: 99%

The protective effect of human renal sinus fat on glomerular cells is reversed by the hepatokine fetuin-A

Wagner

Machann

Guthoff

et al. 2017

Sci Rep

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Renal sinus fat (RSF) is a perivascular fat compartment located around renal arteries. In this in vitro and in vivo study we hypothesized that the hepatokine fetuin-A may impair renal function in non alcoholic fatty liver disease (NAFLD) by altering inflammatory signalling in RSF. To study effects of the crosstalk between fetuin-A, RSF and kidney, human renal sinus fat cells (RSFC) were isolated and cocultured with human endothelial cells (EC) or podocytes (PO). RSFC caused downregulation of proinflammatory and upregulation of regenerative factors in cocultured EC and PO, indicating a protective influence of RFSC. However, fetuin-A inverted these benign effects of RSFC from an anti- to a proinflammatory status. RSF was quantified by magnetic resonance imaging and liver fat content by 1H-MR spectroscopy in 449 individuals at risk for type 2 diabetes. Impaired renal function was determined via urinary albumin/creatinine-ratio (uACR). RSF did not correlate with uACR in subjects without NAFLD (n = 212, p = 0.94), but correlated positively in subjects with NAFLD (n = 105, p = 0.0005). Estimated glomerular filtration rate (eGRF) was inversely correlated with RSF, suggesting lower eGFR for subjects with higher RSF (r = 0.24, p < 0.0001). In conclusion, our data suggest that in the presence of NAFLD elevated fetuin-A levels may impair renal function by RSF-induced proinflammatory signalling in glomerular cells.

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“…MCP-1 is the ligand for CCR-2 and CCR-2 is present almost exclusively on monocytes. Thus, in the setting of inflammation, MCP-1 attracts monocytes out of the bone marrow and recruits them to inflammatory sites(19). While MCP-1 is elevated in various renal diseases such as lupus nephritis, diabetic nephropathy, and transplant rejection, its role is not limited to the kidneys(19).…”

Section: Commentmentioning

confidence: 99%

Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations

Moledina

Isguven

McArthur

et al. 2017

The Annals of Thoracic Surgery

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Background Monocyte chemotactic protein-1 [MCP-1; chemokine C-C Ligand-2 (CCL-2)] is upregulated in ischemia-reperfusion injury and is a promising biomarker of inflammation in cardiac surgery. Methods We measured pre- and postoperative plasma MCP-1 levels in adult patients undergoing cardiac surgery to evaluate the association of perioperative MCP-1 levels with acute kidney injury (AKI) and mortality in TRIBE-AKI- a prospective, multicenter, observational cohort. Results Of the 972 participants in the study, 329 (34%) developed AKI and 45 (5%) developed severe AKI. During median follow-up of 2.9 (2.2–3.5) years, 119 (12%) participants died. MCP-1 levels were significantly higher in those who developed AKI and mortality as compared to those without AKI and mortality, respectively. Participants with preoperative MCP-1 level in the highest tertile (>196 pg/ml) had an increased AKI risk as compared to those in the lowest tertile [<147 pg/ml; OR, 1.43 (1.00–2.05)]; the association appeared similar but was not significant for the severe AKI outcome [OR, 1.48 (0.62–3.54)]. As compared with participants with preoperative MCP-1 level in the lowest tertile, those in the highest tertile had higher adjusted mortality risk [HR, 1.82 (1.40–2.38)]. Similarly, as compared to participants with postoperative MCP-1 level in the lowest tertile, those in the highest tertile had higher adjusted mortality risk [HR, 1.95 (1.09–3.49)]. Conclusions Higher plasma MCP-1 is associated with increased AKI and mortality risk after cardiac surgery. MCP-1 could be used as a biomarker to identify high-risk patients for potential AKI prevention strategies in the setting of cardiac surgery.

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Monocyte chemoattractant protein-1 and the kidney

Abstract: Understanding the role of MCP-1 in monocyte homeostasis and the implications of MCP-1 inhibition in renal disease will help in designing better diagnostic and therapeutic strategies in patients with inflammatory renal disease.

Cited by 157 publications

References 80 publications

Urine Epidermal Growth Factor, Monocyte Chemoattractant Protein-1 or Their Ratio as Biomarkers for Interstitial Fibrosis and Tubular Atrophy in Primary Glomerulonephritis

Urine Epidermal Growth Factor, Monocyte Chemoattractant Protein-1 or Their Ratio as Biomarkers for Interstitial Fibrosis and Tubular Atrophy in Primary Glomerulonephritis

The protective effect of human renal sinus fat on glomerular cells is reversed by the hepatokine fetuin-A

Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations

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