Monocyte Chemoattractant Protein-1 Release Is Higher in Visceral than Subcutaneous Human Adipose Tissue (AT): Implication of Macrophages Resident in the AT

Bruun, Jens Meldgaard; Lihn, Aina S.; Pedersen, Steen B.; Richelsen, Bjørn

doi:10.1210/jc.2004-1696

Cited by 479 publications

(388 citation statements)

References 39 publications

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“…Macrophages reside within adipose tissue, as a function of obesity and/or insulin resistance, and generate many of the same cytokines [9,10,28]. The attraction of monocytes to adipose tissue may be due to local production of monocyte chemoattractant protein-1 [13,29]. Adipocytes enhance chemotaxis and diapedesis of monocytes, via the regulation of endothelial cell adhesion molecules, promoting their infiltration into adipose tissue as macrophages [12].…”

Section: Discussionmentioning

confidence: 99%

“…It appears that macrophages and adipose cells may influence each other via paracrine mediators or direct cellular processes [11]. For example, diapedesis and the infiltration of monocytes and their differentiation into macrophages in adipose tissue were shown to be modulated by factors secreted by adipose cells [12,13]. Macrophages have also recently been implicated in scavenging dying adipocytes [14].…”

Section: Introductionmentioning

confidence: 99%

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Macrophage-conditioned medium inhibits the differentiation of 3T3-L1 and human abdominal preadipocytes

et al. 2006

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Aims/hypothesis: In obesity, a limited adipogenic capacity may promote adipocyte hypertrophy and increase the risk of insulin resistance and type 2 diabetes. Recent data indicate that macrophages reside within adipose tissue in obese rodents and humans. We hypothesised that secreted macrophage factors may inhibit adipogenesis.Materials and methods: Conditioned media from cultured murine J774 or human THP-1 macrophages were collected, and added to either murine 3T3-L1 preadipocytes or human abdominal stromal preadipocytes from subcutaneous or omental fat depots. Results: Macrophage-conditioned medium (MacCM) strongly inhibited 3T3-L1 adipogenesis. Dose-response studies with J774-MacCM revealed that 80 and 100% of J774-MacCM completely suppressed triacylglycerol accumulation as well as the induction of fatty acid synthase, peroxisome proliferator-activated receptor γ, CCAAT/enhancer binding protein α, and adiponectin. Similar inhibitory effects on 3T3-L1 preadipocytes were observed with THP-1-MacCM. Differentiation of human abdominal subcutaneous stromal preadipocytes was moderately reduced (subcutaneous>omental) by J744-MacCM. In contrast, the differentiation of both subcutaneous and omental stromal preadipocytes was completely inhibited by THP-1-MacCM, as determined on the basis of morphology and triacylglycerol accumulation, as well as fatty acid synthase and adiponectin protein expression. Conclusions/interpretation: Secreted macrophage products inhibit the differentiation of 3T3-L1 preadipocytes as well as human abdominal stromal preadipocytes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Macrophage-conditioned medium inhibits the differentiation of 3T3-L1 and human abdominal preadipocytes

et al. 2006

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“…Firstly, VAT to a greater extent than SAT secretes several pro-inflammatory insulin-desensitising cytokines, including TNFα and IL-6 (85,86) . As a result, macrophages, T-cells and dendritic cells are recruited to VAT via various signals, including chemokines synthesised by adipocytes (87)(88)(89) .…”

Section: Adipose Tissue Dysfunctionmentioning

confidence: 99%

Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality

et al. 2014

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Evidence suggests that at a population level, childhood and adolescent obesity increase the long-term risk of chronic diseases such as type 2 diabetes and CVD. At an individual level, however, the metabolic consequences of obesity in youth vary immensely. Despite comparable BMI, some adolescents develop impaired glucose tolerance while others maintain normal glucose homeostasis. It has been proposed that the variation in the capacity to store lipid in the subcutaneous adipose tissue (SAT) may partially discriminate metabolically healthy from unhealthy obesity. In positive energy balance, a decreased capacity to expand SAT may drive lipid accumulation to visceral adipose tissue, liver and skeletal muscle. This state of lipotoxicity is associated with chronic low-grade inflammation, insulin resistance and dyslipidaemia. The present review examines the differential adipose tissue development and function in children and adolescents who exhibit metabolic dysregulation compared with those who are protected. Additionally, the role of manipulating dietary fat quality to potentially prevent and treat metabolic dysfunction in obesity will be discussed. The findings of the present review highlight the need for further randomised controlled trials to establish the effect of dietary n-3 PUFA on the metabolic phenotype of obese children and adolescents. Furthermore, using a personalised nutrition approach to target interventions to those at risk of, or those with established metabolic dysregulation may optimise the efficacy of modifying dietary fat quality.

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“…In fact, EAT and PAT are associated with multiple markers of inflammation, vascular dysfunction, and oxidative stress, including C-reactive protein, fibrinogen, intracellular adhesion molecule-1, interleukin-6, MCP-1, P-selectin, tumor necrosis factor receptor-2, and urinary isoprostanes, vascular endothelial growth factor, and plasminogen activator inhibitor-1 (23)(24)(25). Increased levels of the chemokine MCP-1 in visceral adipose tissue attract more monocytes and macrophages, inducing a self-sustaining inflammatory cycle (26,27).…”

Section: Pathophysiologymentioning

confidence: 99%

Increased Epicardial, Pericardial, and Subcutaneous Adipose Tissue Is Associated with the Presence and Severity of Coronary Artery Calcium

Ahmadi¹,

Nabavi²,

Yang³

et al. 2010

Academic Radiology

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Monocyte Chemoattractant Protein-1 Release Is Higher in Visceral than Subcutaneous Human Adipose Tissue (AT): Implication of Macrophages Resident in the AT

Cited by 479 publications

References 39 publications

Macrophage-conditioned medium inhibits the differentiation of 3T3-L1 and human abdominal preadipocytes

Macrophage-conditioned medium inhibits the differentiation of 3T3-L1 and human abdominal preadipocytes

Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality

Increased Epicardial, Pericardial, and Subcutaneous Adipose Tissue Is Associated with the Presence and Severity of Coronary Artery Calcium

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