Monocyte chemoattractant protein-1, transforming growth factor-β1, nerve growth factor, resistin and hyaluronic acid as serum markers: comparison between recurrent acute and chronic pancreatitis

Kamath, M Ganesh; Pai, C. Ganesh; Kamath, Asha; Kurien, Annamma

doi:10.1016/s1499-3872(15)60029-7

Cited by 14 publications

(5 citation statements)

References 32 publications

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“…Other experimental studies have shown that administration of growth factors attenuates pancreatic damage and accelerates pancreatic recovery [ 3 , 28 ]. Transforming growth factor- β 1 (TGF- β 1) is one of the most important regulatory factors with the ability to (1) reduce neutrophil adherence to endothelial cells, (2) promote angiogenesis in the pancreas, and (3) stimulate the transient increase in fibroblast proliferation and deposition of extracellular matrix which creates a platform for pancreatic regeneration [ 29 , 30 ]. In our studies, regeneration parameters of TGF- β 1, smooth muscle actin positive stellate cells, and ki-67-positive cells all significantly improved with rhubarb treatment between day 2 and day 5, thus indicating the active regeneration process in the pancreas.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells

Zhao

Xiong

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Da-Cheng-Qi-Decoction (DCQD) has been used in the treatment of acute pancreatitis (AP) in China for many years. The aim of the current study was to examine the principal ingredient rhubarb of DCQD and its potential link to the pancreatic repair effects in rats with AP. The pancreatitis was induced in SD rats by intraperitoneal injections of cerulein. The results showed that rhubarb significantly increased blood perfusion of pancreatic tissue, reversed mitochondrial damage, and promoted pancreatic acinar and stellate cell proliferation. In addition, the rhein (from rhubarb) had high distribution in pancreas tissue and protected mitochondria in AR42J cells via the activation of PI3K/AKT/mTOR signaling pathway and activity inhibition of AMPK (P < 0.05). The results provide some preclinical evidence on the protective effects of DCQD for the treatment of acute pancreatitis. Rhein is regarded to be the active compound of rhubarb and can be expected to be a new compound for the treatment of AP.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells

Zhao

Xiong

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…But these results are also interesting because it is reasonable to attribute such improvements to the reduction in the repeated episodes of pain and the associated inflammation within the pancreatic parenchyma. Mild, transient exocrine and endocrine dysfunction are known following acute episodes of pancreatitis and progression of RAP to CP has been attributed to recurrent episodes of inflammation[18,32,33]. Also, progression of pancreatic insufficiency has been associated with recurrent painful episodes in patients with CP[34].…”

Section: Discussionmentioning

confidence: 99%

Continuing episodes of pain in recurrent acute pancreatitis: Prospective follow up on a standardised protocol with drugs and pancreatic endotherapy

Pai

Kamath

Shetty

et al. 2017

WJG

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AIMTo assess the outcomes of drug therapy (DT) followed by pancreatic endotherapy for continuing painful episodes in recurrent acute pancreatitis.METHODSDT comprised of pancreatic enzymes and anti-oxidants failing which, endotherapy (ET; pancreatic sphincterotomy and stent placement) was done. The frequency of pain, its visual analogue score (VAS), quality of life (QoL), serum C peptide and faecal elastase were compared between baseline and after 1 year of follow up in all patients and in the two subgroups on DT and ET. Response was defined as at least 50% reduction in the severity of pain to below a score of 5.RESULTSOf the thirty nine patients analysed, 21 (53.9%) responded to DT and 18 (46.1%) underwent ET. The VAS for pain (7.0 ± 2.0 vs 1.3 ± 2.5, P < 0.001) and the number of days with pain per month decreased [1.0 (1.0, 2.0) vs 1.0 (0.0, 1.0), P < 0.001], and the QoL scores [55.0 (44.0, 66.0) vs 38.0 (32.00, 51.00), P < 0.01] improved significantly during follow up. Similar significant improvements were seen in patients in the subgroups of DT and ET except for QoL in ET. The serum C-peptide (P = 0.001) and FE (P < 0.001) levels improved significantly in the entire group and in the two subgroups of patients except for the C peptide levels in patients on DT.CONCLUSIONA standardised protocol of DT, followed by ET decreased the intensity and frequency of pain in recurrent acute pancreatitis, enhanced QoL and improved pancreatic function.

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“…It is possible that the additional use of biomarkers will improve the staging systems and this needs to be explored in future studies. An earlier report from our centre showed that serum MCP-1 levels were lower in patients with CP and EPI as compared to those diagnosed with CP but without EPI[ 30 ]. Future studies combining tests for pancreatic function and biomarkers may help in the early detection of CP.…”

Section: Discussionmentioning

confidence: 99%

Comparing acid steatocrit and faecal elastase estimations for use in M-ANNHEIM staging for pancreatitis

Kamath

Pai

Kamath

et al. 2017

WJG

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AIMTo compare two tests for exocrine pancreatic function (EPF) for use in M-ANNHEIM staging for pancreatitis.METHODSOne hundred and ninety four consecutive patients with acute pancreatitis (AP; n = 13), recurrent acute pancreatitis (RAP; n = 65) and chronic pancreatitis (CP; n = 116) were enrolled. EPF was assessed by faecal elastase-1 (FE-1) estimation and stool fat excretion by the acid steatocrit method. Patients were classified as per M-ANNHEIM stages separately based on the results of the two tests for comparison. Independent Student’s t-test, χ2 test, Kruskal-Wallis test, Mann-Whitney U test and McNemar’s test were used as appropriate.RESULTSSixty-one (52.5%) patients with CP had steatorrhoea when assessed by the acid steatocrit method; 79 (68.1%) with CP had exocrine insufficiency by the FE-1 test (χ2 test, P < 0.001). The results of acid steatocrit and FE-1 showed a significant negative correlation (Spearman’s rho = -0.376, P < 0.001). A statistically significant difference was seen between the M-ANNHEIM stages as classified separately by acid steatocrit and the FE-1. Thirteen (6.7%), 87 (44.8%), 89 (45.8%) and 5 (2.5%) patients were placed in M-ANNHEIM stages 0, I, II, and III respectively, with the use of acid steatocrit as against 13 (6.7%), 85 (43.8%), 75 (38.6%), and 21 (10.8%) respectively by FE-1 in stages 0, I, II, and III thereby altering the stage in 28 (14.4%) patients (P < 0.001, McNemar’s test).CONCLUSIONFE-1 estimation performed better than the acid steatocrit test for use in the staging of pancreatitis by the M-ANNHEIM classification since it diagnosed a higher proportion of patients with exocrine insufficiency.

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Monocyte chemoattractant protein-1, transforming growth factor-β1, nerve growth factor, resistin and hyaluronic acid as serum markers: comparison between recurrent acute and chronic pancreatitis

Cited by 14 publications

References 32 publications

Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells

Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells

Continuing episodes of pain in recurrent acute pancreatitis: Prospective follow up on a standardised protocol with drugs and pancreatic endotherapy

Comparing acid steatocrit and faecal elastase estimations for use in M-ANNHEIM staging for pancreatitis

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