Monocyte chemotactic and activating factor is a potent histamine-releasing factor for human basophils.

Kuna, Piotr; Reddigari, Sesha R.; Rucinski, Doreen; Oppenheim, Joost J.; Kaplan, Allen P.

doi:10.1084/jem.175.2.489

Cited by 177 publications

(78 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CCL2 is produced by a variety of cell types in response to inflammatory stimuli and chemoattracts and activates monocytes, T cells, NK cells and basophils [12][13][14][15][16][17]. Elevated levels of CCL2 have been detected in plasma of sepsis patients, after administration of LPS to human volunteers, and in animal models of endotoxemia or septic peritonitis [11,[18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

CC chemokine receptor 2 regulates leukocyte recruitment and IL‐10 production during acute polymicrobial sepsis

Feterowski

Mack²,

Weighardt

et al. 2004

Eur J Immunol

View full text Add to dashboard Cite

Chemokine receptors are important for recruiting leukocytes to sites of infection and may contribute to immune cell activation. The present study investigated the role of the chemokine receptor CCR2 in polymicrobial septic peritonitis. The results showed that peritoneal production of the CCR2 ligands CCL2 and CCL12 in septic mice was largely independent of the common Toll-like receptor signaling adaptor MyD88. Antibody blockade of CCR2 reduced the recruitment of macrophages and neutrophils to the infected peritoneal cavities of both wild-type and MyD88-deficient mice, suggesting that CCR2 engagement contributes to the MyD88-independent cellular response against polymicrobial septic peritonitis. Notably, administration of blocking CCR2 antibodies markedly increased local and systemic IL-10 levels in septic wild-type mice, whereas IL-10 was not detected in MyD88-deficient mice irrespective of whether CCR2 was blocked or not. Inhibition of CCR2 directly augmented Tolllike receptor-induced IL-10, but not TNF and IL-6, production of macrophages in vitro. Concomitant with enhanced IL-10 production, CCR2 blockade caused impaired bacterial clearance and aggravated kidney injury in wild-type, but not MyD88-null mice. These results indicate that CCR2 engagement modulates the innate immune response to polymicrobial septic peritonitis by both MyD88-dependent and -independent processes and suggest that a major function of CCR2 in sepsis is to attenuate IL-10 production and IL-10-mediated suppression of host defense.

show abstract

Section: Introductionmentioning

confidence: 99%

CC chemokine receptor 2 regulates leukocyte recruitment and IL‐10 production during acute polymicrobial sepsis

Feterowski

Mack²,

Weighardt

et al. 2004

Eur J Immunol

View full text Add to dashboard Cite

show abstract

“…4 This HRF was distinct from histamine release induced by monocyte chemotactic protein-1 (MCP-1), which is a potent activation stimulus of basophils from all donors. [5][6][7] After purification and cloning, HRF was found to be identical to TCTP, which is also known as p23. 8 This recombinant molecule was found to have the same properties as the originally described HRF derived from nasal secretions: namely, an ability to induce histamine release from selected donors.…”

Section: Introductionmentioning

confidence: 99%

“…[23][24][25][26][27] In addition, IL-3 is the most potent stimulus of augmentation of IgE-mediated histamine release. 5,28 This enhanced response is referred to as priming. Furthermore, several studies have demonstrated that IL-3 induces phosphorylation of various signaling pathways, including JAK2, Shc, STAT5, Grb2, ras, and ERK.…”

Section: Introductionmentioning

confidence: 99%

Distinct characteristics of signal transduction events by histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)–induced priming and activation of human basophils

Vonakis¹,

MacGlashan²,

Vilariño³

et al. 2008

Blood

View full text Add to dashboard Cite

We previously identified a negative correlation between histamine release to histamine releasing factor/translationally controlled tumor protein (HRF/TCTP) and protein levels of the Src homology 2 domain-containing inositol 5 phosphatase (SHIP) in basophils. We have also demonstrated that HRF/TCTP primes basophils to release mediators. The purpose of this study was to begin characterization of signal transduction events directly induced by HRF/TCTP and to investigate these events when HRF/TCTP is used as a priming agent for human basophil histamine release. Highly purified human basophils were examined for surface expression of bound HRF/TCTP, changes in calcium, and phosphorylation of Akt, mitogen-activated protein kinase kinase ( IntroductionTranslationally controlled tumor protein (TCTP) was originally identified in the 1980s by Brawerman's group as a tumor protein in a mouse acidic tumor and in mouse erythroleukemia. However, no function for the protein was identified. 1,2 We identified a histamine releasing factor (HRF) found in late-phase fluids from nasal lavages, bronchoalveolar lavage fluids, and skin blister fluids that directly induced histamine release from basophils isolated from a subpopulation of allergic donors. 3 We have previously published that approximately 50% of allergic donor basophils respond to HRF/TCTP. 4 This HRF was distinct from histamine release induced by monocyte chemotactic protein-1 (MCP-1), which is a potent activation stimulus of basophils from all donors. 5-7 After purification and cloning, HRF was found to be identical to TCTP, which is also known as p23. 8 This recombinant molecule was found to have the same properties as the originally described HRF derived from nasal secretions: namely, an ability to induce histamine release from selected donors. This protein is ubiquitously expressed as an intracellular protein, and homologs of HRF/TCTP have been described in parasites, including Plasmodium falciparum, Wucheria bancrofti, Brugiia malea, and Schistosoma mansinai, all of which possess mast cell/basophil histamine-releasing activity. [9][10][11] HRF/TCTP appears to have both intracellular and extracellular functions. One group identified the antiapoptotic activities of this molecule and renamed it fortilin. 12 Our group, as well as another group, has identified the interaction between HRF/TCTP and elongation factor-1␦, also known as eElongation factor 1B-␤. 13,14 Thus, HRF/TCTP may have an intracellular role in interfering with the elongation step of protein synthesis.We, as well as others, have focused on the extracellular functions of HRF/TCTP. HRF/TCTP was initially described as a complete secretagog for histamine and IL-4 secretion from basophils of certain allergic donors. 15 Initially, it was thought that these donors had a certain type of IgE that interacted with HRF/TCTP to induce secretion. 15 However, it was subsequently demonstrated that HRF/TCTP primed HRF/TCTP non-responder (HRF/TCTP-NR) basophils for histamine release as well as IL-4 and IL-13 secretion regar...

show abstract

“…MCP-1 is a member of the CC chemokine family (19). It influences monocytes (20,21), natural killer cells (22), basophils (23), and T lymphocytes (24), all of which express chemokine receptors (25), predominantly CC-chemokine receptor 2 (CCR2; ref. 26).…”

mentioning

confidence: 99%

Monocyte Chemoattractant Protein-1 Transfection Induces Angiogenesis and Tumorigenesis of Gastric Carcinoma in Nude Mice via Macrophage Recruitment

Kuroda¹,

Kitadai²,

Tanaka

et al. 2005

Clinical Cancer Research

121

View full text Add to dashboard Cite

Purpose: Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that has various roles in tumor development and progression. We previously reported that expression of MCP-1 is associated with macrophage infiltration and tumor vessel density in human gastric carcinomas. The present study was undertaken to obtain direct evidence that MCP-1 participates in recruitment of macrophages and induction of angiogenesis. Experimental Design:We did transfection experiments to analyze the role of MCP-1 in tumorigenicity and angiogenesis in gastric carcinoma in nude mice. The human MCP-1 gene cloned into the BCMGS-Neo expression vector was transfected into the human gastric carcinoma TMK-1 cell line. We examined tumor volumes with the ectopic s.c. xenograft model and tumorigenicity with the orthotopic gastric xenograft model. We determined intratumor microvessel counts and tumor-infiltrating macrophage counts by immunohistochemical staining. Results: There was no difference in in vitro proliferation between MCP-1-transfected TMK-1 cells and mock-transfected (control) cells; however, MCP-1 transfectants induced tumor growth in ectopic xenografts and increased tumorigenicity and induced lymph node metastases and ascites in orthotopic xenografts. In both ectopic and orthotopic xenograft models, strong infiltration of macrophages was observed within and around the tumors after implantation of MCP-1 transfectants whereas fewer macrophages were seen after inoculation of control cells. The microvessel density was significantly higher in tumors produced by MCP-1 transfectants than in control tumors. Conclusions: MCP-1 produced by gastric carcinoma cells may regulate angiogenesis via macrophage recruitment. MCP-1 may be a potential target for antiangiogenic therapy for gastric carcinoma.

show abstract

Monocyte chemotactic and activating factor is a potent histamine-releasing factor for human basophils.

Cited by 177 publications

References 31 publications

CC chemokine receptor 2 regulates leukocyte recruitment and IL‐10 production during acute polymicrobial sepsis

CC chemokine receptor 2 regulates leukocyte recruitment and IL‐10 production during acute polymicrobial sepsis

Distinct characteristics of signal transduction events by histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)–induced priming and activation of human basophils

Monocyte Chemoattractant Protein-1 Transfection Induces Angiogenesis and Tumorigenesis of Gastric Carcinoma in Nude Mice via Macrophage Recruitment

Contact Info

Product

Resources

About