Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells

Arıcı, Aydın; Oral, Engin; Attar, Erkut; Tazuke, Salli I.; Olive, David L.

doi:10.1016/s0015-0282(97)81440-9

Cited by 205 publications

(191 citation statements)

References 19 publications

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“…During the IVF procedure, the mechanical barrier is removed and the fecundity of the spermatozoa can be proven in vitro [23]. In contrast, in women with endometriosis one possible mechanism for reduced fertilization rates is compromised oocyte quality [3,[26][27][28]. This is consistent with results of a study that evaluated pregnancy rates of patients undergoing IVF with donated oocytes, which showed that recipients who had endometriosis conceived with no difference than those with other causes of infertility.…”

Section: Discussionsupporting

confidence: 71%

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Komsky-Elbaz

Raziel

Friedler

et al. 2012

J Assist Reprod Genet

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Purpose This study compares the fertilization rate and embryonic development of oocytes randomly inseminated by conventional IVF or ICSI in patients with endometriosis and normozoospermic semen during IVF cycles. Methods Sibling oocytes were randomized to be inseminated either by ICSI or IVF. Rates of fertilization, cleavage, blastulation and embryonic morphology were assessed. Results A total of 786 sibling cumulus-oocyte complexes (COC) were randomized between insemination by conventional IVF (387 COC) or ICSI (399 COC). A significantly higher fertilization rate was found in the ICSI group (ICSI versus IVF, 73.3±23 % versus 54.7±31.9 % respectively; P=0.003), yielding a higher mean number of day 2 embryos (5.2±3.4 versus 3.6±2.9 respectively; P=0.002). Triploid fertilization rate (3PN/COC) was significantly higher in the IVF group compared to the ICSI group (3.9±8.7 % versus 0.9±3.1 % respectively; P=0.02). The morphology score and rate of development of day 2 and 3 embryos were not different between the two groups. Comparison of embryo transfer cycles in which either IVF or ICSI only embryos were transferred did not reveal any statistically significant differences in pregnancy or implantation rates.Conclusion ICSI appears to be a better treatment option than conventional IVF in endometriosis-associated infertility, since it offers the advantages of higher fertilization rate and mean number of embryos and lower rate of total fertilization failure and triploid fertilization.

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Section: Discussionsupporting

confidence: 71%

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Komsky-Elbaz

Raziel

Friedler

et al. 2012

J Assist Reprod Genet

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“…It has been observed that increased peritoneal fluid level of IL-8 in patients with endometriosis observed in this study supports the results of previous studies (24).…”

Section: Discussionsupporting

confidence: 93%

Relationship between cytokines and the embryotoxicity of hydrosalpingeal fluid

Falcone

Goldberg

Attaran

et al. 2005

J Assist Reprod Genet

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Objective : The exact chemical composition of hydrosalpingeal fluid is unknown. The objective of this study was to characterize cytokines in hydrosalpingeal fluid (HSF) and examine their possible role in the embryo development. Study Design : HSF was aspirated at laparoscopic salpingectomy in eight infertile women. Levels of IL-1β, IL-13, IL-8, IL-6 and TNF-α in the HSF were determined by quantitative immunoassay kits. Two-cell mouse embryos were incubated with 0, 25, 50 and 75% concentrations of HSF. The blastocyst development rate (BDR) of mouse embryos was measured at each HSF concentration. Result(s) :The embryotoxicity of HSF was concentration dependent. An increase in the HSF concentration resulted in significant decrease in % BDR (p < 0.01). IL-1β was present in six of the eight HSF samples with a mean (±SD) concentration of 0.9 ± 0.8 pg/mL. IL-13 was not detected in any of the HSF samples. IL-8, IL-6 and TNF-α were detected in all samples with a mean (±SD) concentration of 4741.2 ± 6554.4 pg/mL, 204.8±132.8 pg/ml and 12 ± 12.8 pg/mL respectively. IL-6 was positively correlated with BDR (r = 0.53; p < 0.04). Conclusion(s) :We demonstrated for the first time the presence of IL-1β, IL-8, IL-6 and TNF-α and the absence of IL-13 in human hydrosalpingeal fluid. IL-6 was positively related to the BDR.

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“…Moreover, it has been manifested that angiogenesis is essential for the development of EMs. IL-8, a chemokine that is a potent angiogenic factor, has been reported being elevated in the peritoneal fluid of women with EMs, and its level correlates with the severity of the disease [17,18] . Harada and his colleagues reported that the interaction between TWEAK and Fn-14 would induce HUVEC secret IL-8, suggesting that up-regulated expression of IL-8 in the peritoneal cavity could affect the expression of TWEAK on ectopic endometrium inversely, with whose down-regulation leading to the apoptosis level of endometrial cells on ectopic site decreasing further [7] .…”

Section: Discussionmentioning

confidence: 99%

Expression of TWEAK on the Ectopic and Eutopic Endometrium from Women with Endometriosis

Qian

Jin

2008

Journal of Reproduction and Contraception

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Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells

Cited by 205 publications

References 19 publications

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Relationship between cytokines and the embryotoxicity of hydrosalpingeal fluid

Expression of TWEAK on the Ectopic and Eutopic Endometrium from Women with Endometriosis

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