Monocyte Count: A Risk Factor for Coronary Heart Disease?

Olivares, Robert; Ducimetière, Pierre; Claude, Jean

doi:10.1093/oxfordjournals.aje.a116601

Cited by 195 publications

(142 citation statements)

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“…In addition, monocytes release tissue necrosis factor-a (TNF-a) that has been related to insulin resistance. 25,26 We noted that in our overweight youth neutrophils (39%) and monocytes (34%) increased more than lymphocytes (24%). Since the granulocytes and monocytes appear to be related to CHD, 27,28 our results suggest that these detrimental processes may start very early on in life.…”

Section: Discussionmentioning

confidence: 69%

Body fat and circulating leukocytes in children

et al. 2006

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Objective: To determine the effects of obesity on baseline levels of circulating granulocytes, monocytes, and lymphocyte subtypes in otherwise healthy children. Design: Two group comparison of leukocytes in normal weight control and overweight children. Subjects: In total, 38 boys and girls, ages 6-18 years, divided in two groups: normal weight, (NW, BMIo85th %tile, n ¼ 15) and overweight (OW, body mass index (BMI)485th %tile, n ¼ 23). Measurements: BMI obtained from direct measures of height and body mass. Body fat was assessed by DEXA. Complete blood counts (CBC) were obtained by standard clinical hematology methods and surface antigen staining by flow cytometry. Results: The OW group compared to the NW group had increased total leukocytes counts (P ¼ 0.011), neutrophils (P ¼ 0.006), monocytes (P ¼ 0.008), total T (CD3) lymphocytes (P ¼ 0.022), and Helper T (CD4 þ ) cells (P ¼ 0.003). Significant correlations were evident between leukocytes, and BMI percentile, BMI, or percent body fat. Neither lean body mass nor VO 2peak per unit lean body mass were significantly related to any of the leukocytes. Percent body fat and BMI percentile were positively correlated (Po0.05) to total T cells (CD3) and/or helper T cells (CD4 þ ). Conclusion: A group of 23 overweight children displayed elevated counts in most types of circulating immune cells, suggesting the presence of low-grade systemic inflammation, a known pathogenetic mechanism underlying most long-term complications of obesity. Our data provide an additional rationale for the importance of avoiding or correcting pediatric obesity.

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Section: Discussionmentioning

confidence: 69%

Body fat and circulating leukocytes in children

et al. 2006

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“…19,20) Furthermore, the Paris Prospective study II indicated that a high monocyte count was strongly associated with the risk of coronary heart disease after adjustment for tobacco use and the other classical risk factors for the disease. 21) Monocytes isolated from coronary sinus blood in UA patients expressed significantly higher levels of CD11b / CD18 than monocytes isolated from the aorta, while the monocytes of SA patients or normal subjects did not exhibit this difference in the expression level of CD11b between monocytes isolated from coronary sinus vs. aorta. 22) Peripheral blood monocytes isolated from AMI patients also expressed significantly higher amounts of lymphocyte function associated antigen-1 (LFA-1), CD11b / CD18, very late activating antigen-4 (VLA-4), and intercellular adhesion molecule-1 (ICAM-1) than control subjects.…”

Section: Discussionmentioning

confidence: 91%

Correlation between Monocyte and T-lymphocyte Activation Markers in Patients with Acute Coronary Syndrome.

Choi

Lee

et al. 2000

Jpn Heart J

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SUMMARYEvidence suggesting the involvement of activated monocytes and T-lymphocytes in the acute phase of coronary artery disease (CAD) has been increasing. But a detailed analysis of a correlation between monocyte and T-lymphocyte activation markers in CAD has not yet been done. We analyzed plasma C-reactive protein (CRP) levels and the expression levels of CD14 and CD11b on monocytes and the percentage of HLA-DR + T-lymphocytes in 25 patients with acute coronary syndrome (ACS), 12 stable angina (SA) patients, and 23 control subjects using flow-cytometry. The expression of CD14 by monocytes was increased significantly in ACS patients (activation index = 38.7 ± 2.5, mean ± SEM) in comparison to the control subjects (8.0 ± 1.9) and the SA patients (16.9 ± 3.9) (p < 0.001 and p < 0.01, respectively). The expression of CD11b by monocytes of ACS patients (4.6 ± 0.6) was also increased significantly in comparison to control subjects (2.2 ± 0.1) and the SA patients (2.2 ± 0.3) (p < 0.001 for both). Also, a significantly higher percentage of HLA-DR positive T-lymphocytes (19.2 ± 1.8 vs 13.5 ± 1.2%, p < 0.05) was observed among ACS patients in comparison to control subjects. Significant increases in plasma CRP levels were also detected in ACS patients. Furthermore, there were statistically significant correlations among these activation markers. These results indicate that activation of inflammatory cells may play a role in the pathogenesis of ACS. The correlation between the activation status of monocytes and T-lymphocytes indicates that the activation of these immune cells is linked in such a way that activation of one type of cell may lead to the activation of another type of cell. (Jpn Heart J 2000; 41: 605-615) Key words: CD14, CD11b, HLA-DR, Unstable angina, Stable angina, Inflammation, Flow cytometry INCREASING evidence suggests that inflammatory changes and activation of immune cells are involved in the acute phase of atherosclerosis.1) The atherosclerotic plaques of AMI and UA patients are considered active plaques and vulneraFrom the Cardiology Division, Cardiovascular Institute,

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“…The utility of differential leukocyte counts as a risk marker has been evaluated in a number of studies [12][13][14]. However, it is still different among studies that which type of WBC is more important.…”

Section: Discussionmentioning

confidence: 99%

“…An increase in the count is closely correlated with advanced atherosclerosis [10], and the incidence and mortality rate of CVD [11]. Various types of inflammatory cells, including monocytes, lymphocytes, eosinophils, and neutrophils, have been implicated in CHD [12][13][14]. Nevertheless, it is still different among studies that which type of WBCs is more important.…”

Section: Introductionmentioning

confidence: 99%