Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation

Chow, Kevin V.; Lew, Andrew M.; Sutherland, Robyn M.; Zhan, Yifan

doi:10.4049/jimmunol.1501202

Cited by 60 publications

(72 citation statements)

References 65 publications

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“…Whether such cells are poor APCs remains undetermined. Indeed, we had previously shown that moDCs were capable of inhibiting T cell proliferation induced by cDCs (23).…”

Section: Discussionmentioning

confidence: 99%

“…They have been observed to arise in many different types of infections, including Listeria monocytogenes (26), Leishmania major (39), and Trypanasoma (40), as well as participating in the pathogenesis of a number of inflammatory conditions, such as asthma (41) and experimental autoimmune encephalomyelitis (37). They can also be induced by systemic inflammatory meditators, for example TLR signaling through LPS administration (42), or in systemic GM-CSF transgenesis (23). Nevertheless, despite an increasingly broad understanding of their biology and function, the role of moDCs in the setting of organ transplantation has been less well characterized.…”

Section: Discussionmentioning

confidence: 99%

“…2 (23). We used Ly6G as an additional marker to ensure that neutrophils were completely excluded from these populations (Fig.…”

Section: Flow Cytometrymentioning

confidence: 99%

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Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells

Chow

Delconte

Huntington

et al. 2016

The Journal of Immunology

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Although the mechanisms governing the innate recognition of pathogen-associated molecular patterns have been well defined, how allogeneic cellular stimuli evoke innate responses remains less so. In this article, we report that upon i.v. transfer (to avoid major iatrogenic interference), allogeneic but not syngeneic leukocytes could induce a rapid (after 1 d) accumulation of host monocyte–derived dendritic cells (moDCs) without any increase in conventional DCs. This occurred in various donor–host strain combinations, did not require MHC mismatch, and could be induced by various donor cell types including B cells, T cells, or NK cells. Using RAG−/−γc−/− and scid γc−/−mice with different MHC, we found that the presence of either donor or host lymphoid cells was required. Alloinduced moDC accumulation was significantly reduced when splenocytes from mice deficient in NK cells by genetic ablation were used as donors. A major component of this moDC accumulation appears to be recruitment. Our findings provide new insights into how the innate and adaptive immune system may interact during allogeneic encounters and thus transplant rejection.

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“…Whether such cells are poor APCs remains undetermined. Indeed, we had previously shown that moDCs were capable of inhibiting T cell proliferation induced by cDCs (23).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells

Chow

Delconte

Huntington

et al. 2016

The Journal of Immunology

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“…Three main mechanisms have been proposed. First, monocytes may directly kill either the effector T cells or antigen-bearing cDCs via NO 79,121,122 . Second, killing may result from the sequestration of cysteine, a process that can be counterbalanced by cysteine supplementation 123 .…”

Section: Box 2 | Classical Dendritic Cell Subsets In Cross-presentationmentioning

confidence: 99%

Monocyte differentiation and antigen-presenting functions

Jakubzick¹,

Randolph

Henson³

2017

Nat Rev Immunol

719

641

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Monocytes develop in the bone marrow and represent the primary type of mononuclear phagocyte found in the blood. They were long thought of as a source for tissue macrophages, but recent studies indicate more complex roles for monocytes, both within the circulation and after their migration into tissues and lymphoid organs. In this Review, we discuss the newer concepts underlying the maturation of emigrating monocytes into different classes of tissue macrophages, as well as their potential functions, as monocyte-derived cells, in the tissues. In addition, we consider the emerging roles for monocytes in adaptive immunity as antigen-presenting cells.

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“…Many reports indicate, however, that monocytederived DCs stimulate T cells poorly despite their prodigious capacity to uptake and process Ags (18,28). Flow cytometric analysis of freshly isolated tumor DCs from Zbtb46-DTR and WT bone marrow chimeras revealed that they express similar levels of intracellular iNOS and TNF.…”

Section: Tumor Dc3 Stimulate Ctl Proliferationmentioning

confidence: 99%

Tumor Dendritic Cells (DCs) Derived from Precursors of Conventional DCs Are Dispensable for Intratumor CTL Responses

Diao

Tang

et al. 2018

The Journal of Immunology

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The success of adoptive CTL therapy for cancer depends on interactions between tumor-infiltrating CTLs and cancer cells as well as other cells and molecules in the tumor microenvironment. Tumor dendritic cells (DCs) comprise several subsets: CD103+CD11b− DC1 and CD11b+CD64− DC2, which originate from circulating precursors of conventional DCs, and CD11b+CD64+ DC3, which arise from monocytes. It remains controversial which of these subset(s) promotes intratumor CTL proliferation, expansion, and function. To address this issue, we used the Zbtb46-DTR–transgenic mouse model to selectively deplete DC1 and DC2 from tumors and lymphoid tissues. Wild-type and Zbtb46-DTR bone marrow chimeras were inoculated with B16 melanoma cells that express OVA and were treated with OT-1 CTLs. We found that depletion of DCs derived from precursors of conventional DCs in Zbtb46-DTR bone marrow chimeras abolished CTL proliferation and expansion in tumor-draining lymph nodes. By contrast, intratumor CTL accumulation, proliferation, and IFN-γ expression were unaffected by their absence. We found that adoptive cell therapy increases the frequency of monocyte-derived tumor DC3, which possess the capacity to cross-present tumor Ags and induce CTL proliferation. Our findings support the specialized roles of different DC subsets in the regulation of antitumor CTL responses.

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Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation

Cited by 60 publications

References 65 publications

Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells

Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells

Monocyte differentiation and antigen-presenting functions

Tumor Dendritic Cells (DCs) Derived from Precursors of Conventional DCs Are Dispensable for Intratumor CTL Responses

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