Monocyte function in cattle experimentally infected with bovine immunodeficiency-like virus

Rovid, Anna H.; Carpenter, Susan; Roth, James A.

doi:10.1016/0165-2427(94)05326-n

Cited by 11 publications

(3 citation statements)

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“…In this study, lymphocyte proliferative responses to the mitogens concanavalin A and pokeweed mitogen were not significantly different between principals and controls. Previous studies have reported both increased (10) and decreased (16) lymphocyte blastogenesis as well as depressed neutrophil function (10), depressed monocyte function (18), and no change in monocyte function (20). All of those studies were conducted with the attenuated R29 strain of BIV, often contaminated with a noncytopathic strain of BVDV (22).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies using cattle have been done to assess changes in immune cell function following BIV inoculation, with different results including decreased (16) and increased (10) lymphocyte blastogenesis, depressed (18) and unaffected (20) monocyte function, and decreased (10) neutrophil function. In all of these studies, cattle were inoculated with the attenuated R29 strain of BIV, often contaminated with a noncytopathic strain of bovine viral diarrhea virus (BVDV) (6,22).…”

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confidence: 99%

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Bovine lentivirus induces early transient B-cell proliferation in experimentally inoculated cattle and appears to be pantropic

Whetstone

Suarez

Miller

et al. 1997

J Virol

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Much work has been done on the molecular characterization of BIV in studies using the original BIV R29 isolate; however, R29 is believed to be attenuated since it no longer causes either mononuclear cell number increases or detectable enlargement of lymphatic nodules in experimentally infected cattle. The host cell tropism and changes in host peripheral blood lymphocyte populations following infection with BIV are unknown. Recently, we isolated and characterized a field isolate of BIV, FL112 (D. L. Suarez et al., J. Virol. 67:5051-5055, 1993) that causes a transient, mononuclear cell lymphocytosis in experimentally infected cattle. In the present study, cattle were inoculated with BIV FL112, and data from flow cytometry showed that BIV causes a B-cell lymphocytosis with no consistent, significant changes in other mononuclear cell populations, including CD3 ؉ , CD4 ؉ , and CD8 ؉ cells. Cell sorting and PCR amplification were used to show that BIV may be pantropic. Proviral DNA was present in CD3 ؉ , CD4 ؉ , CD8 ؉ , and B-cells, monocytes, and WC1 cells (␥/␦ T cells, null cells) by 3 to 6 days postinoculation and also at 2.5 years postinoculation.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Bovine lentivirus induces early transient B-cell proliferation in experimentally inoculated cattle and appears to be pantropic

Whetstone

Suarez

Miller

et al. 1997

J Virol

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“…and every 8–12 weeks thereafter through 4 years p.i. Haematological evaluation, including total and differential leukocyte analysis, clinical evaluation and evaluation of immune function have been reported previously (Flaming et al , 1993 , 1997 ; Rovid et al , 1995 ). Results from these in vivo studies indicated that animals co-infected with BIV and BLV did not differ from singly infected animals in any parameters of immune function, virus replication or pathological sequelae that have been examined.…”

Section: Methodsmentioning

confidence: 85%

Antigenic and genetic stability of bovine immunodeficiency virus during long-term persistence in cattle experimentally infected with the BIVR29 isolate

Carpenter

Vaughn

Yang

et al. 2000

Journal of General Virology

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Experimental infection of cattle with bovine immunodeficiency virus (BIV) is characterized by persistent, low levels of virus replication in the absence of clinical disease. A virus neutralization (VN) assay was developed to examine the role of VN antibodies in controlling virus replication in cattle experimentally infected with the BIV R29 isolate of BIV. All animals developed VN antibody, but there was no correlation between VN titres and restriction of virus replication in vivo. BIV infection did not induce high-titred, cross-neutralizing antibody and there was no evidence for antigenic variation through more than 4 years in vivo. Genetic comparisons among the BIV R29 inoculum virus and viruses isolated from infected animals identified only limited genetic variation during 4 years in vivo. Moreover, there was no evidence that the observed variation was due to selection. Analyses of genetic diversity in the virus stock used for inoculation indicated a fairly homogeneous population. In the absence of high levels of virus replication and overt clinical disease, there appeared to be little selection of virus variants, resulting in antigenic and genetic stability of BIV R29 during long-term, persistent infection.

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The comparative pathology of the lentiviruses

Campbell

Robinson

1998

Journal of Comparative Pathology

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Monocyte function in cattle experimentally infected with bovine immunodeficiency-like virus

Cited by 11 publications

References 10 publications

Bovine lentivirus induces early transient B-cell proliferation in experimentally inoculated cattle and appears to be pantropic

Bovine lentivirus induces early transient B-cell proliferation in experimentally inoculated cattle and appears to be pantropic

Antigenic and genetic stability of bovine immunodeficiency virus during long-term persistence in cattle experimentally infected with the BIVR29 isolate

The comparative pathology of the lentiviruses

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