Monocyte/HDL Ratio and Lymphocyte/Monocyte Ratio in Patients with Pseudoexfoliation Syndrome

Mirza, Enver; Oltulu, Refik; Katipoğlu, Zeynep; Mirza, Günsu Deniz; Özkağnıcı, Ahmet

doi:10.1080/09273948.2018.1545913

Cited by 24 publications

(24 citation statements)

References 39 publications

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“…In literature, there are two studies that aim to evaluate MHR in ocular diseases. In the first study, Mirza et al (26) found high MHR values in glaucoma patients. In the second one, MHR level was high in patients with retinal venous occlusion (27).…”

Section: Discussionmentioning

confidence: 96%

Monocyte to HDL ratio as an indicator of subclinical atherosclerosis in diabetic retinopathy

Kan

Karaibrahimoğlu

2020

Journal of Health Sciences and Medicine

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Amaç: Diyabetik retinopatisi olan hastalarda kardiyovasküler hastalıkların artan sıklığı bilinmektedir. MHO (Monosit/HDL oranı), kardiyovasküler ve serebrovasküler hastalıklarla ilişkisi yeni saptanmış bir belirteçtir. Bu çalışmanın amacı aşikar kardiyovasküler hastalık bulgusu olmayan diyabetik retinopatisi olan hastalarda subklinik ateroskleroz risk göstergesi karotis intima media kalınlığı (KİMK) ile MHO ilşkisini araştırmaktır. Gereç ve Yöntem: Aşikar kardiyovasküler hastalığı olmayan 106 diyabetik hasta ve 35 yaş, cinsiyet ve BMI (body mass index) ile uyumlu sağlıklı kontrol alındı. Hastalar proliferatif diyabetik retinopati (PDR, n=30), nonproliferatif diyabetik retinopati (NPDR, n=35), retinopati olmayan diyabet hastaları (n=41) ve kontrol grubu (n=35) olmak üzere dört gruba ayrıldı. Antropometrik, biyokimyasal parametreler ve KİMK ölçüldü. MHO ile KİMK arasındaki ilişkiyi değerlendirmek için korelasyon ve regresyon analizi yapıldı. Bulgular: MHO değerleri gruplar arasında anlamlı farklılığa sahip ve PDR grubunda anlamlı düzeyde daha yüksekti (p<0.001). Ateroskleroz göstergesi olan KİMK gruplar arasında anlamlı farklılık gösterdi (p<0.001). KİMK değeri PDR grubunda anlamlı düzeyde yüksek iken diğer gruplarda birbirine yakın değerler ölçüldü. PDR grubunda MHO ile KİMK arasında önemli düzeyde anlamlı korelasyon bulundu (r=0,96; p<0.001). Binary logistic regression analizinde MHO'nin KİMK üzerine anlamlı etkisi bulunmaktaydı [β=0,206, (%95 CI: 1,004-1,505), p=0,046]. Sonuç: Bu çalışma, yüksek MHO'nın diyabetik retinopatisi olan hastalarda subklinik kardiyovasküler riski belirlemede non-invaziv, basit ve maliyeti düşük bir marker olarak kullanılabileceğini göstermektedir. Diyabetik retinopatide MHO ve KİMK arasındaki ilişkiyi inceleyen literatürdeki ilk çalışma olan bu çalışma, aşikar kardiyovasküler hastalık bulgusu olmayan diyabetik hastalardaki kardiyak riski erken belirlemede fayda sağlayabilir.

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Section: Discussionmentioning

confidence: 96%

Monocyte to HDL ratio as an indicator of subclinical atherosclerosis in diabetic retinopathy

Kan

Karaibrahimoğlu

2020

Journal of Health Sciences and Medicine

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“…demonstrated that the MHR was significantly higher in patients with than without pseudoexfoliation syndrome or glaucoma. [ 18 19 20 36 ] In addition, Satirtav et al . found that increased MHRs significantly related to branch retinal vein occlusion.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers have also demonstrated that monocyte-to-HDL ratios (MHR) are relatively high in several systemic and ocular disorders associated with inflammation including ischemic stroke, coronary artery stenosis, pseudoexfoliation syndrome or glaucoma, and branch retinal vein occlusion. [ 17 18 19 20 ]…”

mentioning

confidence: 99%

“…Although MHR has been studied in several diseases related to systemic and local inflammation, such as branch retinal vein occlusion, diabetic retinopathy, and exfoliation syndrome, its association with CSC has not been reported yet. [ 19 20 21 ] Since the pathogenesis of CSC seems to be related to systemic inflammation, we aimed to investigate whether elevated MHRs and NLRs are important predictors of CSC. To our knowledge, our study marks the first to have involved the evaluation of MHRs in patients with CSC.…”

mentioning

confidence: 99%

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Monocyte to high-density lipoprotein and neutrophil-to-lymphocyte ratios in patients with acute central serous chorioretinopathy

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et al. 2020

Indian J Ophthalmol

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Purpose: To investigate monocyte to high-density lipoprotein (HDL) ratio (MHR) and neutrophil-to-lymphocyte ratio (NLR) as indicators of systemic inflammation in acute central serous chorioretinopathy (CSC). Methods: The HDL levels, hematological profiles, erythrocyte sedimentation rates (ESR), and C-reactive protein (CRP) levels of 38 patients with acute CSC (Group I) and 38 controls without CSC (Group II) were measured. Results: MHRs were significantly higher in Group I (13.30 ± 2.95) than in Group II (11.52 ± 2.42, P = 0.005), whereas NLRs, CRP values, and ESR values did not significantly differ between the groups ( P = 0.726, P = 0.219, and P = 0.441, respectively). Multivariate analysis revealed that the MHR was an independent predictor of acute CSC (OR = 1.266, 95% CI = 1.054-1.521, P = 0.012). Conclusion: Indicating an association between increased MHRs and acute CSC, the MHR might represent simple, inexpensive, reliable biomarkers of inflammation in acute CSC.

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“…Therefore, MHR has been studied as a marker of both oxidative stress and inflammation in many diseases [12][13][14]. In view of the foregoing, it is aimed with this study to evaluate the serum MHR level in manic state of bipolar disorder.…”

Section: Introductionmentioning

confidence: 99%

Bipolar bozukluk manik dönemde monosit/yüksek dansiteli lipoprotein kolesterol oranının değerlendirilmesi

Çalışkan

Çokünlü

2021

Family Practice and Palliative Care

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Introduction: Bipolar disorder has been linked to abnormalities in the immune/inflammatory functions. Monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) is used as chronic inflammation markers. The aim of this retrospective study was to investigate the MHR levels in manic patients with bipolar disorder. Methods: The study included 100 male patients, 49 of whom were in the first episode and 51 of whom had multiple episodes, hospitalized with a diagnosis of bipolar disorder manic state and 50 healthy individuals with characteristics comparable to the patient group in terms of gender and age. MHR values were calculated on the basis of the obtained hemograms, and the results of the biochemistry blood tests and lipid panel analyses and recorded. Kruskal Wallis test was used to compare the MHR values among the first episode, multiple episodes, and healthy control groups. Results: There was no statistically significant difference between the patients and controls in terms of age, whereas the mean age of the patients who had multiple episodes was significantly higher than the first episode. MHR values were found to be statistically significantly higher in the first episode and multiple episodes group than healthy controls. There was no statistically significant difference between the MHR levels of the patients, who were in the first episode, and of the patients who had multiple episodes. Conclusion:This study is consistent with the results of studies reporting inflammation in the manic episode of bipolar disorder and therefore may indicate the presence of inflammation in the manic episode.

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Monocyte/HDL Ratio and Lymphocyte/Monocyte Ratio in Patients with Pseudoexfoliation Syndrome

Cited by 24 publications

References 39 publications

Monocyte to HDL ratio as an indicator of subclinical atherosclerosis in diabetic retinopathy

Monocyte to HDL ratio as an indicator of subclinical atherosclerosis in diabetic retinopathy

Monocyte to high-density lipoprotein and neutrophil-to-lymphocyte ratios in patients with acute central serous chorioretinopathy

Bipolar bozukluk manik dönemde monosit/yüksek dansiteli lipoprotein kolesterol oranının değerlendirilmesi

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