Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report

Urbanowicz, Tomasz; Michalak, Michał; Olasińska-Wiśniewska, Anna; Rodzki, Michał; Krasińska, Aleksandra; Perek, Bartłomiej; Krasiński, Zbigniew; Jemielity, Marek

doi:10.3390/jpm11121266

Cited by 11 publications

(11 citation statements)

References 23 publications

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“…However, all the participants in our study were patients with CHD, and the relationship between MLR and carotid plaque was stronger than that between MLR and NLR. [22][23][24] More recently, some clinical studies showed that MLR was related to CHD severity; MLR > 0.3 has predictive values for colleterial carotid stenosis and may be used as an easily accessible indicator for AS severity. These findings were consistent with the results of the present study.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Monocyte-to-Lymphocyte Ratio as Well as Other Leukocyte-Derived Ratios and Carotid Plaques in Patients with Coronary Heart Disease: A RCSCD-TCM Study

Ma¹,

Liu²,

Wang³

et al. 2022

JIR

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Purpose This study explored the relationship between monocyte-to-lymphocyte ratio (MLR) as well as other leukocyte-derived ratios and carotid plaques in patients with coronary heart disease (CHD). Patients and Methods A total of 12,093 patients with CHD were selected as research participants. Leukocyte-derived ratios assessed in this study included neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), MLR, platelet-to-lymphocyte ratio (PLR), white blood cell-to-mean platelet volume ratio (WMR), lymphocyte×neutrophil/10 4 ratio (MNM), systemic immune inflammation index (SII), and systemic inflammation response index (SIRI). Leukocyte-derived ratios were divided into four groups according to quarters. Logistic regression analysis was performed to evaluate the relationship between leukocyte-derived ratios and the incidence, number, and echo characteristics of carotid plaques in patients with CHD. Further analysis was performed after adjusting for confounding factors. Results Among the 12,093 participants, 71.7% had carotid plaques. After adjusting for confounding factors, MLR, NLR, dNLR, PLR, SII, SIRI, and WMR were found to be associated with carotid plaque formation. Among them, MLR had the strongest association with the incidence of carotid plaques (odd ratio[OR]:1.889; 95% confidence interval[CI]:1.406–2.539) and hyperechoic plaques (OR:2.024; 95% CI:1.481–2.767). When MLR was viewed as a categorical variable, the risk of carotid plaque formation in Q4 was 1.4 times higher than that in Q1. The relationship between MLR and carotid plaques in females (OR:2.250; 95% CI:1.458–3.473) was stronger than that in males (OR: 1.638; 95% CI:1.102–-2.436). The relationship between MLR and carotid plaques in patients younger than 65 years (OR:3.597; 95% CI:2.379–5.439) was stronger than that in those older than 65 years (OR:1.577; 95% CI:1.046–2.378). Conclusion Leukocyte-derived ratios were related to the incidence, number, and echo characteristics of carotid plaques. In particular, MLR, an inflammatory biomarker that encompasses innate and adaptive immunity, may be of great value in revealing the incidence and echo characteristics of plaques.

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Section: Discussionmentioning

confidence: 99%

Relationship Between Monocyte-to-Lymphocyte Ratio as Well as Other Leukocyte-Derived Ratios and Carotid Plaques in Patients with Coronary Heart Disease: A RCSCD-TCM Study

Ma¹,

Liu²,

Wang³

et al. 2022

JIR

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“… 27 In contrast, Tomasz Urbanowicz and Serhat Karaman found that high MCHC had a similar role in predicting the severity of carotid artery disease and acute coronary syndromes. 18 , 19 It suggested that the prognosis of MCHC for cardiovascular disease is mixed.…”

Section: Discussionmentioning

confidence: 99%

“…MCHC, a common indicator of anemia, has been shown to correlate with the prognosis of myocardial infarction, congestive heart failure (CHF), acute coronary syndrome, and atherosclerosis severity. 16 – 19 However, as a common cardiovascular disease, few studies on the association between MCHC and APE. Therefore, we plan to conduct a study to investigate the relationship between MCHC and prognosis in patients with APE.…”

Section: Introductionmentioning

confidence: 99%

The Association Between Mean Corpuscular Hemoglobin Concentration and Prognosis in Patients with Acute Pulmonary Embolism: A Retrospective Cohort Study

Ruan

et al. 2022

Clin Appl Thromb Hemost

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Introduction Acute pulmonary embolism (APE) is a typical cardiovascular emergency worldwide. Mean hemoglobin concentration (MCHC) is a standard indicator of anemia. Studies on the association between MCHC and APE are scarce. We aimed to investigate the relationship between MCHC and APE. Methods Clinical data were extracted from the Medical Information Bank for Intensive Care (MIMIC)-III. Adult (≥18 years) patients with APE admitted for the first time were included in this study. An analysis was conducted to evaluate the association between MCHC and the prognosis of patients by the Cox regression analysis, generalized additives models and Kaplan–Meier survival curves. The primary outcome was 30-day mortality, and the secondary outcomes were 1-year and 3-year mortality. Results A total of 813 patients who met the selection criteria were enrolled, of whom 130 (16.0%) died within 30 days of admission. Univariate Cox regression indicated that MCHC was significantly associated with mortality (30-day: HR = 0.74, 95% CI = 0.66–0.82, P < 0.001; 1-year: HR = 0.80, 95% CI = 0.74–0.86, P < 0.001; 3-year: HR = 0.82, 95% CI = 0.77–0.88, P < 0.001). MCHC remains stable after adjusting multiple models. Kaplan-Meier survival curves showed that patients with lower MCHC had a poorer 30-day prognosis. Conclusions Lower MCHC is an independent risk factor for increased mortality in patients with APE. As an inexpensive biomarker, MCHC should receive more attention.

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“…According to studies on the pathogenesis of w-AIHA, autoantibodies, the complement system, phagocytes, cytotoxic CD8 + T cells and NK cells performing ADCC, B and T lymphocytes (including CD4 + T regulatory (Treg) cells), and cytokines play important roles in the pathogenesis of w-AIHA ( 1 ). When either a high concentration of IgG or IgG with high affinity to complement C is bound to erythrocytes, the destruction of RBCs may increase as they pass through the spleen ( 1 , 29 ). Therefore, we hypothesize that the IgG concentration in the sera of w-AIHA patients with type O blood may remain high for a long time, promoting recurrence by activating complement C or directly coating the surfaces of erythrocytes, which may require serological testing for confirmation.…”

Section: Discussionmentioning

confidence: 99%

“…The mean corpuscular hemoglobin concentration, which is an index that reflects the average volume of RBCs, is recognized as an indicator of the average HGB concentration per RBC and is predictive of the development of a variety of diseases, including chronic obstructive pulmonary disease (COPD), internal carotid artery stenosis, and hepatocellular carcinoma (HCC) metastasis ( 29 – 31 ). Based on the multivariate logistic regression analysis, the MCHC ( OR = 0.968, 95% CI is 0.938–0.998, P = 0.040) was found to be a protective factor for the early recurrence of primary w-AIHA in children, and the ROC curve analysis and survival analysis showed that patients with primary w-AIHA with an MCHC value of ≥313.5 pg/fL at the initial diagnosis had a lower recurrence rate.…”

Section: Discussionmentioning

confidence: 99%

Type O blood, the MCHC, and the reticulocyte count impact the early recurrence of primary warm-antibody autoimmune hemolytic anemia in children: A retrospective cohort analysis

et al. 2022

Front. Pediatr.

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ObjectivePrimary warm-antibody autoimmune hemolytic anemia (w-AIHA) is prone to recurrence in children. In this study, we aimed to identify risk indicators for the early recurrence of primary w-AIHA and construct an effective recurrence risk assessment model.MethodsThis was a retrospective cohort study. The clinical data of patients hospitalized with primary w-AIHA in the Department of Hematology and Oncology, Children's Hospital of Chongqing Medical University, between 1 January 2018 and 30 September 2021, were collected at the initial diagnosis. Univariate and multivariate logistic regression analyses were used to determine risk indicators for the early recurrence of primary w-AIHA in children, and ROC curve and Kaplan–Meier survival analyses were used for verification. Finally, a risk assessment model for early recurrence in children with primary w-AIHA was constructed using Cox regression and visualized using a nomogram. The model was also verified internally and externally.ResultsThis study included 62 children with primary w-AIHA. Of which, 18 experienced recurrence 1 year after the initial diagnosis. The univariate and multivariate logistic regression analyses showed that type O blood and the reticulocyte count (Ret) were risk indicators for the early recurrence of pediatric primary w-AIHA (P = 0.009, 0.047, respectively). The mean corpuscular hemoglobin concentration (MCHC) is a protective factor (P = 0.040). According to the ROC curve and Kaplan–Meier survival analyses, children with primary w-AIHA whose blood type was O or had an MCHC of <313.5 pg/fL or a Ret of ≥0.161×1012/L had a higher risk of early recurrence (HR = 2.640, 4.430 and 4.450, respectively, and P = 0.040, 0.015 and 0.018, respectively). The blood types (O), MCHCs, and Rets of 56 patients were incorporated into the Cox regression model, and the recurrence risk assessment model for children with primary w-AIHA was successfully constructed and visualized using a nomogram. The calibration curves and decision-curve analysis (DCA) suggested that the risk model has clinical applicability and effectiveness.ConclusionChildren with type O blood and an MCHC value of <313.5 pg/fL or a Ret value of ≥0.161×1012/L have a higher risk of early recurrence. The risk assessment model for the early recurrence of pediatric primary w-AIHA constructed in this study has good clinical applicability and effectiveness.

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Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report

Cited by 11 publications

References 23 publications

Relationship Between Monocyte-to-Lymphocyte Ratio as Well as Other Leukocyte-Derived Ratios and Carotid Plaques in Patients with Coronary Heart Disease: A RCSCD-TCM Study

Relationship Between Monocyte-to-Lymphocyte Ratio as Well as Other Leukocyte-Derived Ratios and Carotid Plaques in Patients with Coronary Heart Disease: A RCSCD-TCM Study

The Association Between Mean Corpuscular Hemoglobin Concentration and Prognosis in Patients with Acute Pulmonary Embolism: A Retrospective Cohort Study

Type O blood, the MCHC, and the reticulocyte count impact the early recurrence of primary warm-antibody autoimmune hemolytic anemia in children: A retrospective cohort analysis

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