Monocyte‐related cytokines/chemokines in cerebral ischemic stroke

Mei-ling, Bai; Sun, Ruize; Cao, Bin; Feng, Juan; Wang, Jue

doi:10.1111/cns.14368

Cited by 24 publications

(13 citation statements)

References 130 publications

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“…SDF-1α is produced by activated astrocytes, microglia, and vascular endothelial cells. It plays a crucial role in recruiting monocytes locally to the injured brain region after ischaemic stroke 39 – 41 and mobilises endothelial progenitor cells, thus promoting angiogenesis 42 . Elevated SDF-1α levels have been observed in individuals with cardiovascular risk factors 43 , 44 , and plasma levels have been linked to adverse cardiovascular outcomes in people with coronary artery disease 45 .…”

Section: Discussionmentioning

confidence: 99%

Peripheral inflammatory response in people after acute ischaemic stroke and isolated spontaneous cervical artery dissection

Bauer,

Boehme,

Mayer-Suess

et al. 2024

Sci Rep

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The systemic inflammatory response following acute ischaemic stroke remains incompletely understood. We characterised the circulating inflammatory profile in 173 acute ischaemic stroke patients by measuring 65 cytokines and chemokines in plasma. Participants were grouped based on their inflammatory response, determined by high-sensitivity C-reactive protein levels in the acute phase. We compared stroke patients’ profiles with 42 people experiencing spontaneous cervical artery dissection without stroke. Furthermore, variations in cytokine levels among stroke aetiologies were analysed. Follow-up samples were collected in a subgroup of ischaemic stroke patients at three and twelve months. Ischaemic stroke patients had elevated plasma levels of HGF and SDF-1α, and lower IL-4 levels, compared to spontaneous cervical artery dissection patients without stroke. Aetiology-subgroup analysis revealed reduced levels of nine cytokines/chemokines (HGF, SDF-1α, IL-2R, CD30, TNF-RII, IL-16, MIF, APRIL, SCF), and elevated levels of IL-4 and MIP-1β, in spontaneous cervical artery dissection (with or without ischaemic stroke as levels were comparable between both groups) compared to other aetiologies. The majority of cytokine/chemokine levels remained stable across the study period. Our research indicates that stroke due to large artery atherosclerosis, cardioembolism, and small vessel occlusion triggers a stronger inflammatory response than spontaneous cervical artery dissection.

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Section: Discussionmentioning

confidence: 99%

Peripheral inflammatory response in people after acute ischaemic stroke and isolated spontaneous cervical artery dissection

Bauer,

Boehme,

Mayer-Suess

et al. 2024

Sci Rep

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“…In the present study, we discovered opposing age-associated neuroimmune responses during the acute phase of stroke, which has far-reaching implications for stroke management in both pediatric and adult populations. While other investigators have found beneficial effects of neuroimmune responses after stroke in adults, it is typically during the chronic phase of stroke [ 30 , 74 , 76 ], after irreparable damage to newly generated neurons has already occurred. Instead, we observe a predominantly anti-inflammatory gene expression profile in MCAO-injured juveniles during the time shortly before newborn neurons matured and subsequent neuroplasticity was restored, while expression of all anti-inflammatory mediators was downregulated in adults following stroke ( Figure 5 ).…”

Section: Discussionmentioning

confidence: 99%

Neuroimmune Support of Neuronal Regeneration and Neuroplasticity following Cerebral Ischemia in Juvenile Mice

Marquez-Ortiz,

Tesic,

Hernandez

et al. 2023

Brain Sciences

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Ischemic damage to the brain and loss of neurons contribute to functional disabilities in many stroke survivors. Recovery of neuroplasticity is critical to restoration of function and improved quality of life. Stroke and neurological deficits occur in both adults and children, and yet it is well documented that the developing brain has remarkable plasticity which promotes increased post-ischemic functional recovery compared with adults. However, the mechanisms underlying post-stroke recovery in the young brain have not been fully explored. We observed opposing responses to experimental cerebral ischemia in juvenile and adult mice, with substantial neural regeneration and enhanced neuroplasticity detected in the juvenile brain that was not found in adults. We demonstrate strikingly different stroke-induced neuroimmune responses that are deleterious in adults and protective in juveniles, supporting neural regeneration and plasticity. Understanding age-related differences in neuronal repair and regeneration, restoration of neural network function, and neuroimmune signaling in the stroke-injured brain may offer new insights for the development of novel therapeutic strategies for stroke rehabilitation.

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“…In addition, one of the chemokines that is most highly expressed in the ipsilateral hemisphere of MCAO models is CCL2. 229,230,239,240 CCR2-MSCs enhanced neurological consequences, decreased BBB leakage levels, and dramatically increased migration to the ischemic lesions. Furthermore, the BBB's defense decreased the production of reactive oxygen species (ROS) and the infiltration of inflammation.…”

Section: Bang Et Al Used a Rat Stroke Model To Study The Impact Of Ad...mentioning

confidence: 93%

Therapeutic gene delivery by mesenchymal stem cell for brain ischemia damage: Focus on molecular mechanisms in ischemic stroke

Saleh,

Majeed,

Margiana

et al. 2024

Cell Biochemistry & Function

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Cerebral ischemic damage is prevalent and the second highest cause of death globally across patient populations; it is as a substantial reason of morbidity and mortality. Mesenchymal stromal cells (MSCs) have garnered significant interest as a potential treatment for cerebral ischemic damage, as shown in ischemic stroke, because of their potent intrinsic features, which include self‐regeneration, immunomodulation, and multi‐potency. Additionally, MSCs are easily obtained, isolated, and cultured. Despite this, there are a number of obstacles that hinder the effectiveness of MSC‐based treatment, such as adverse microenvironmental conditions both in vivo and in vitro. To overcome these obstacles, the naïve MSC has undergone a number of modification processes to enhance its innate therapeutic qualities. Genetic modification and preconditioning modification (with medications, growth factors, and other substances) are the two main categories into which these modification techniques can be separated. This field has advanced significantly and is still attracting attention and innovation. We examine these cutting‐edge methods for preserving and even improving the natural biological functions and therapeutic potential of MSCs in relation to adhesion, migration, homing to the target site, survival, and delayed premature senescence. We address the use of genetically altered MSC in stroke‐induced damage. Future strategies for improving the therapeutic result and addressing the difficulties associated with MSC modification are also discussed.

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Monocyte‐related cytokines/chemokines in cerebral ischemic stroke

Cited by 24 publications

References 130 publications

Peripheral inflammatory response in people after acute ischaemic stroke and isolated spontaneous cervical artery dissection

Peripheral inflammatory response in people after acute ischaemic stroke and isolated spontaneous cervical artery dissection

Neuroimmune Support of Neuronal Regeneration and Neuroplasticity following Cerebral Ischemia in Juvenile Mice

Therapeutic gene delivery by mesenchymal stem cell for brain ischemia damage: Focus on molecular mechanisms in ischemic stroke

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