Monocyte to HDL Cholesterol Ratio and its association with cardio-metabolic risk factors in Primary Hyperparathyroidism

Monocyte Count to HDL-Cholesterol Ratio May Be a Novel Cardiometabolic Marker in Patients With Functional Adrenal Tumors

“…This process induces inflammation, subsequently participates in the beginning and progression of atherosclerosis (7); therefore, monocytes count suggests as a predictor of premature occurrence of cardiovascular events (2). HDL-C possesses anti-oxidant, anti-inflammatory, anti-thrombotic, and anti-atherosclerotic effects by inhibiting the migration of macrophage, suppressing the LDL oxidation, and interrupting the cholesterol efflux from macrophages (1,2,8,37). HDL-C interrupts the activation of monocytes and inhibits the differentiation of monocytes to macrophages (1).…”

“…Monocytes are major source of pro-inflammatory and pro-oxidant cytokines (1,2). Monocytes interact with platelets and endothelial cells, which initiates pro-thrombotic and pro-inflammatory process (3).…”

“…Circulating monocytes and macrophages initiates the pathogenesis of cardiovascular disease (CVD), through this atherosclerosis and inflammatory process (6). High-density lipoproteins cholesterol (HDL-C) decreases atherosclerosis by inhibiting pro-inflammatory and pro-oxidant effects of monocytes (2,4). Hence, decreased of HDL-C and accumulation of monocyte may participate in CVD and atherosclerosis (1).…”