Monocyte-to-HDL Ratio (MHR) Predicts Vitamin D Deficiency in Healthy and Metabolic Women: A Cross-Sectional Study in 1048 Subjects

Matteis, Carlo De; Crudele, Lucilla; Cariello, Marica; Battaglia, Stefano; Piazzolla, Giuseppina; Suppressa, Patrizia; Sabbá, Carlo; Piccinin, Elena; Moschetta, Antonio

doi:10.3390/nu14020347

Cited by 14 publications

(12 citation statements)

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“…We previously identified increased visceral adipose tissue and oxidative stress as predisposing conditions to impaired reverse cholesterol transport (RCT), a process in which HDL particles are critically involved ( 33 ). In this study, HDL level intriguingly shows significant correlations with FPG and WC only in subjects with benign nodules, while a significant direct correlation with 25-OH vitamin D, as previously reported ( 34 , 35 ), was found only in patients with malignant nodules. On the one hand, the paradoxical uncoupling of cholesterol bioavailability and synthesis has already been shown in cancer cells ( 36 ).…”

Section: Discussionsupporting

confidence: 87%

Thyroid nodule malignancy is associated with increased non-invasive hepatic fibrosis scores in metabolic subjects

Crudele,

Novielli,

De Matteis

et al. 2023

Front. Oncol.

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IntroductionThyroid cancer incidence is increasing, and adiposity-related conditions are gaining space in its pathogenesis. In this study, we aimed to detect any anthropometric, biohumoral, and clinical features that might be associated with thyroid nodule malignancy, potentially representing novel non-invasive markers of thyroid cancer.Materials and methodsThe study was conducted in a group of 142 consecutive outpatients (47 men and 95 women) who underwent fine-needle aspiration biopsy/cytology (FNAB/C) due to suspicion of malignancy from January 2018 to September 2022. We compared lipid and glycemic blood profiles as well as non-invasive liver fibrosis indexes such as aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AAR), AST to platelet ratio index (APRI), and fibrosis index based on four factors (FIB-4) between patients with benign and malignant newly diagnosed nodules. Then, we performed receiver operating characteristic (ROC) analysis to assess their best cutoff values for discrimination of malignant nodules and chi-squared test to evaluate the association of specific dysmetabolic conditions with malignancy. To understand whether and to what degree dysmetabolic conditions increased the risk of thyroid nodule malignancy, we also calculated the odds ratio (OR) of the main biomarkers.ResultsAfter FNAB/C, 121 (85%) patients were diagnosed with benign thyroid nodules, while 21 (15%) individuals were diagnosed with thyroid cancer. Comparing patients with benign and malignant nodules, we found that individuals with thyroid cancer exhibited increased body mass index (BMI) (p = 0.048) and fasting plasma glucose (p = 0.046). Intriguingly, considering non-invasive scores for liver fibrosis, subjects with thyroid cancer presented increased AAR (p < 0.001) and APRI (p = 0.007), and these scores were associated with malignancy (p < 0.005) with OR = 7.1 and OR = 5, respectively. Moreover, we showed that only in the cancer group, low levels of vitamin D correlated with stigmata of impaired metabolism.DiscussionIn our study, AAR and APRI scores were associated with thyroid nodule malignancy and could be used to predict it and to speed up the diagnostic process. From a pathogenic point of view, we speculated that metabolic-associated fatty liver disease (MAFLD) along with hyperglycemia and vitamin D deficiency may represent putative drivers of thyroid carcinogenesis.

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Section: Discussionsupporting

confidence: 87%

Thyroid nodule malignancy is associated with increased non-invasive hepatic fibrosis scores in metabolic subjects

Crudele,

Novielli,

De Matteis

et al. 2023

Front. Oncol.

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“…Furthermore, Jiang et al found that MHR was significantly related to all-cause and cardiovascular mortality in the general population independent of established risk factors (9). De Matteis et al reported that MHR was independently correlated with vitamin D deficiency in healthy and metabolic women (29). All clinical findings indicated MHR can be a predictive marker for other kinds of chronic inflammatory disease like MetS.…”

Section: Discussionmentioning

confidence: 99%

“…De Matteis et al. reported that MHR was independently correlated with vitamin D deficiency in healthy and metabolic women ( 29 ). All clinical findings indicated MHR can be a predictive marker for other kinds of chronic inflammatory disease like MetS.…”

Section: Discussionmentioning

confidence: 99%

Monocyte to High-Density lipoprotein and Apolipoprotein A1 Ratios: Novel Indicators for Metabolic Syndrome in Chinese Newly Diagnosed Type 2 Diabetes

et al. 2022

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ObjectiveIncreasing evidence highlighted that chronic inflammation involved in the development of metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM). This prospective study was aimed to assess the association between MetS and novel pro-inflammatory indicators like monocyte–to–high-density lipoprotein and monocyte–to–apolipoprotein A1 ratios (MHR and MAR) in Chinese newly diagnosed T2DM.MethodA total of 605 Chinese newly diagnosed T2DM with complete and available data were enrolled in this study. Demographic and anthropometric information were collected. Laboratory assessments were determined by standard methods. MetS was based on the Chinese Diabetes Society definition. Multiple binomial logistic regression model was used to estimate the independent variables of MHR and MAR for MetS. Receiver operating characteristic (ROC) curve was conducted to assess the optimal cutoff value of MHR and MAR in identifying MetS.ResultsOverall, the prevalence of MetS was 60.2%. The correlation analysis showed that MHR and MAR were closely correlated with metabolic risk factors like body mass index, waist circumference, triglycerides, high-density lipoprotein cholesterol, systolic blood pressure, diastolic blood pressure, uric acid, and insulin resistance. MHR and MAR were also significantly associated with higher odds of MetS after adjustment for other confounders, the odds ratios (ORs) (95%CI) were 1.50 (1.14–1.97) and 2.26(1.79–2.87) respectively. Furthermore, MHR and MAR were also seemed to have higher area under the curve (AUC) for MetS than ApoA1 and monocyte alone from the ROC curve analysis (P < 0.05). The AUCs of MHR and MAR identifying MetS were 0.804 (95% CI: 0.768–0.839) and 0.840 (95% CI: 0.806–0.873) respectively (P < 0.001). The optimal cutoff values of MHR and MAR were 3.57 × 108/mmol (sensitivity: 76.1%, specificity: 73.4%) and 3.95 × 108/g (sensitivity: 79.7%, specificity: 84.6%), respectively.ConclusionsMHR and MAR were significantly associated with MetS. These two novel pro-inflammatory indicators may be useful markers for MetS in Chinese newly diagnosed T2DM.

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“…Low vitamin D levels have been linked to an increase in chronic low-grade inflammation through its direct action on different pro-inflammatory cytokines and chemokines released by macrophages [95]. Previous studies have reported that low levels of vitamin D correlate with increased MHR, independent of metabolic and age status [96,97]. These findings could be due to several mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Effect of Nutrition Education on Health Science University Students to Improve Cardiometabolic Profile and Inflammatory Status

López-Moreno,

Garcés-Rimón,

Miguel-Castro

et al. 2023

Nutrients

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The inadequate lifestyle associated with university life may have a negative impact on various cardiometabolic factors. The aim of this study was to evaluate the effect of a one-year nutrition education course on cardiometabolic parameters in undergraduate health science students. During the 2021–22 academic year, 1.30 h nutrition sessions were conducted twice a week. Capillary blood samples were collected and centrifuged to measure cardiometabolic and inflammatory biomarkers in serum. The sample studied consisted of 49 students: 20.4% male and 79.6% female. The nutritional intervention resulted in changes in dietary patterns, with increased consumption of vegetables, nuts and legumes. After the course, females showed an increase in HDL-cholesterol levels (p = 0.007) and no change in LDL-cholesterol levels (p = 0.189). On the other hand, males showed significant changes in HDL-cholesterol (p = 0.001) and LDL-cholesterol (p = 0.043) levels. The atherogenic index was also significantly reduced (p < 0.001) in both males (p = 0.009) and females (p = 0.002). Differences were also observed in the increase in vitamin D levels in both males and females, although the magnitude of the increase was greater in the men (Δ = 7.94, p = 0.016 in men vs. Δ = 4.96, p = 0.001 in women). The monocyte-to-HDL ratio (MHR) showed a significant reduction, although these differences were only significant in males. Students with low vitamin D levels had higher LDL-cholesterol values (p = 0.01) and atherogenic index (p = 0.029). Adjusted linear regression analysis showed a significant association between post-course vitamin D MHR (β = −0.42, IC: −0.29, −0.06, p < 0.01). These findings suggest the importance of including nutrition education programs during the university stage for the prevention of long-term health problems.

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Monocyte-to-HDL Ratio (MHR) Predicts Vitamin D Deficiency in Healthy and Metabolic Women: A Cross-Sectional Study in 1048 Subjects

Cited by 14 publications

References 54 publications

Thyroid nodule malignancy is associated with increased non-invasive hepatic fibrosis scores in metabolic subjects

Thyroid nodule malignancy is associated with increased non-invasive hepatic fibrosis scores in metabolic subjects

Monocyte to High-Density lipoprotein and Apolipoprotein A1 Ratios: Novel Indicators for Metabolic Syndrome in Chinese Newly Diagnosed Type 2 Diabetes

Effect of Nutrition Education on Health Science University Students to Improve Cardiometabolic Profile and Inflammatory Status

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