Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients With Diabetes Mellitus and Diabetic Nephropathy

Karataş, Ahmet; Türkmen, Ercan; Erdem, Emre; Düğeroğlu, Harun; Kaya, Yasemın

doi:10.2217/bmm-2018-0048

Cited by 44 publications

(45 citation statements)

References 29 publications

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“…This ratio has been widely used to assess the associations between IR and various clinical syn-dromes. Most previous studies on the relationship between TG/HDL-C and the incidence of T2DM reported a positive association [10,16,22], and similar results can be found for type 1 diabetes mellitus [23]. Our findings on TG/HDL-C are consistent with those studies.…”

Section: Discussionsupporting

confidence: 92%

Association of the Ratio of Triglycerides to High-Density Lipoprotein Cholesterol Levels with the Risk of Type 2 Diabetes: A Retrospective Cohort Study in Beijing

Liu

Yan

Chen

et al. 2021

Journal of Diabetes Research

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Background. Previous studies have shown that the ratio of triglyceride to high-density lipoprotein cholesterol level (TG/HDL-C) is a risk factor for type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the nonlinear relationship between TG/HDL-C and the incidence of T2DM in a Chinese population. Methods. We used logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the incidence of T2DM among 7,791 participants from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) cohort study at baseline. Results. After adjusting for age, sex, body mass index, smoking status, alcohol intake, low-density lipoprotein cholesterol level, strenuous activity, education level, family histories of T2DM and tumors, and the presence of hypertension, tumor, stroke, and coronary heart disease, we showed that TG/HDL-C was positively associated with the incidence of T2DM at the 4-year follow-up ( OR = 1.49 , 95 % CI = 1.26 – 1.78 ). TG/HDL-C and incidence of T2DM showed a nonlinear relationship; the inflection point of TG/HDL-C was 1.50. The ORs (95% CI) on the left and right sides of the inflection point were 2.50 (1.70–3.67) and 0.96 (0.67–1.37), respectively. After adjusting for age, sex, and body mass index (BMI) in the linear relationship, the OR of the incidence of T2DM was 1.60 ( 95 % CI = 1.37 – 1.87 ). When the TG/HDL-C was less than 1.50 or greater than 1.76, the ORs (95% CI) were 2.41 (1.82–3.18) or 0.81 (0.53–1.25), respectively. Subgroup analysis showed no relationships of T2DM incidence with sex, BMI, family history of T2DM, or TG/HDL-C. Conclusion. TG/HDL-C is positively associated with diabetes risk. In our study, with each increasing quintile, the risk of T2DM after 4 years was 1.60 or 1.49 depending on the variables adjusted. In addition, our cohort study showed a nonlinear relationship between TG/HDL-C and T2DM incidence, with an inflection point of 1.76 or 1.50, depending on the variables adjusted. When the TG/HDL was less than 1.50, the ORs (95% CI) were 2.41 (1.82–3.18) and 2.50 (1.70–3.67). When the TG/HDL-C was greater than 1.76 or 1.50, there was no significant difference in the change in OR.

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Section: Discussionsupporting

confidence: 92%

Association of the Ratio of Triglycerides to High-Density Lipoprotein Cholesterol Levels with the Risk of Type 2 Diabetes: A Retrospective Cohort Study in Beijing

Liu

Yan

Chen

et al. 2021

Journal of Diabetes Research

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“…Several studies investigated the relationships between hematological parameters and the presence of degenerative complications in type 2 diabetes [ 3 , 6 – 8 , 11 , 13 – 15 , 17 , 18 ], but few explored their prognostic importance for adverse outcomes in longitudinal analyses [ 11 , 22 , 23 ]. Otherwise, these previous studies were mainly retrospective [ 11 , 22 ] and focused on specific hematological parameters, such as the NLR [ 11 , 22 ] and monocytes count [ 23 ], and in specific outcomes, such as cardiovascular events [ 11 ], renal function deterioration [ 22 ] and all-cause mortality [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Importance of hematological parameters for micro- and macrovascular outcomes in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study

Cardoso

Leite

Salles

2021

Cardiovasc Diabetol

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Background The prognostic importance of several hematological parameters has been scarcely investigated in type 2 diabetes. So, we aimed to evaluate their prognostic importance for development of complications in a cohort of type 2 diabetes. Methods In a prospective study, 689 individuals with type 2 diabetes had blood red cell, platelet and leukocyte parameters obtained at baseline. Multivariate Cox analyses examined the associations between several hematological parameters (including neutrophyl-to-lymphocyte, lymphocyte-to-monocyte, platelet-to-lymphocyte, and monocyte-to-HDL ratios) and the occurrence of microvascular (retina, renal and peripheral neuropathy) and cardiovascular complications (total cardiovascular events [CVEs], and major adverse CVEs [MACEs]), and all-cause and cardiovascular mortality. Improvements in risk discrimination were assessed by C-statistics and Integrated Discrimination Improvement (IDI) index. Results During a median follow-up of 10.5 years, 212 patients had a CVE (174 MACEs), 264 patients died (131 cardiovascular deaths); 206 had a renal, 161 a retinopathy and 179 patients had a neuropathy outcome. In multivariate-adjusted analyses, the lymphocytes count and lymphocyte-to-monocyte ratio were protective (hazard ratios [HRs]: 0.77 and 0.72, respectively), whereas the neutrophyl-to-lymphocyte and platelet-to-lymphocyte ratios were associated with increased risks (HRs: 1.19 and 1.17) for all-cause mortality. For cardiovascular mortality, the monocytes count, the neutrophyl-to-lymphocyte and monocyte-to-HDL ratios were associated with increased risks and the lymphocyte-to-monocyte ratio was protective. Higher lymphocyte-to-monocyte ratio was protective for renal failure outcome. However, none of them improved risk discrimination. Conclusions Low lymphocytes count and leukocyte ratios that mainly included lymphocytes were predictors of macrovascular complications and mortality in individuals with type 2 diabetes. However, they did not improve risk prediction over traditional risk factors.

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“…DM is characterized with chronic hyperglycemia that induces oxidative stress, and increased oxidative stress causes the most common microvascular complication of diabetes: DR. Our results suggest that increased MHR, as an inflammatory biomarker, contributes to the progression of chronic inflammation from initiation of diabetes to the progression of diabetic retinopathy. There is one study reported by Karataş et al (15) evaluating the relationship between MHR and diabetes mellitus and diabetic nephropathy. In their study, they showed the increased values of MHR in patients with diabetic nephropathy and its correlation with urine albumin to creatinine ratio.…”

Section: Discussionmentioning

confidence: 99%

Monocyte to high density lipoprotein ratio: a novel inflammation marker related with diabetic retinopathy

Çakir¹,

Arifoğlu²,

Günay³

et al. 2020

Erciyes Med J

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The most common microvascular complication of diabetes is diabetic retinopathy (DR). A new and recently emerged marker of oxidative stress and inflammation is monocyte to high-density lipoprotein cholesterol ratio (MHR). Platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) have also been shown as they are biomarkers of systemic inflammation in various diseases. The present study aims to assess MHR, its predictive value and relations between other inflammation markers in DR patients. Materials and Methods: Sixty-eight patients with DR, fifty-four DM patients without DR and forty-two control subjects were included in this study. Complete blood count, lipoprotein and uric acid levels were recorded. MHR was calculated. Results: MHR, NLR and PLR were statistically significantly higher in DR group than DM without DR group (p=0.008, p=0.042, p=0.003, respectively). Then, receiver operating characteristic (ROC) curve analysis was performed and pointed that MHR predicted DR using a cutoff level of 0.0156 with 63% sensitivity and 76% specificity. Conclusion: In this study, we investigated MHR in DR patients and its relationship with other inflammatory markers, lipoproteins and uric acid. We suggested that an elevated admission of MHR may be of benefit to detect DR and to determine the CVD risk of these patients.

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Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients With Diabetes Mellitus and Diabetic Nephropathy

Cited by 44 publications

References 29 publications

Association of the Ratio of Triglycerides to High-Density Lipoprotein Cholesterol Levels with the Risk of Type 2 Diabetes: A Retrospective Cohort Study in Beijing

Association of the Ratio of Triglycerides to High-Density Lipoprotein Cholesterol Levels with the Risk of Type 2 Diabetes: A Retrospective Cohort Study in Beijing

Importance of hematological parameters for micro- and macrovascular outcomes in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study

Monocyte to high density lipoprotein ratio: a novel inflammation marker related with diabetic retinopathy

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