Monocyte‐to‐lymphocyte ratio and gastrointestinal disorder‐related hospitalization in patients on maintenance hemodialysis

Abstract

IntroductionTo explore the association between monocyte‐to‐lymphocyte ratio (MLR) and the risk of hospitalization due to gastrointestinal (GI) disorder in hemodialysis (HD) patients.MethodsIn this multicenter, observational cohort study, 1626 patients were enrolled in 2019 and followed up to 2 years. Cox regression models were performed to estimate the association of MLR with GI disorder‐related hospitalization risk. Receiver‐operating characteristic (ROC) analyses were conducted to evaluate the cutoff value of MLR in identifying GI disorder‐related hospitalization.ResultsDuring a median follow‐up of 24 months, GI disorder‐related hospitalization occurred in 107 patients. Higher MLR was independently associated with greater risks of GI disorder‐related hospitalization. Furthermore, a cut‐off value of 0.42 differentiated patients with GI disorder‐related hospitalization from those without GI involvement.ConclusionMLR was associated with the occurrence of GI disorder‐related hospitalization in HD patients. The blood MLR could be monitored as a useful marker to predict GI disorder‐related hospitalization.