Monocytic leukæmia with myeloid hyperplasia and localised tumour formation

Abstract

S m a~ Reschad and Schilling-Torgau in 1913 f i s t described monocytic leukemia as a pathological entity, a series of case reports has appeared, sparsely at first, recently with increasing frequency.It would appear t o be a commoner condition than was at first thought and no doubt many cases still pass unrecognised under the embracing diagnosis of acute leukaemia. Apart from its intrinsic interest, monocytic leukaemia is of special importance because of its influence upon our theories of the genealogy of the blood cells and their relation to the reticulo-endothelial system. Upon the vexed questions of the origin of the monocyte and its relation to the other blood cells there is by no means unanimous agreement. We report the following cases because they seem t o us to throw some light on these questions and because of an unusual distribution of the lesions. Case 1. J. D. male, aged 39, coal miner, married. Admitted 8.2.34, died 26.9.34. History of illness.Three weeks before admission patient had a septic throat which subsided For two weoks there was persistent, sovere headache, chieflySince hc took ill the He had complained of tender gums for in a few days. frontal, and this ww the predominant complaint. temperature had been about 100" 5'. about ten days. Previous health good. State on admission.Tho mucous membranes were palo, the gums swollen, soft and tender, with bleeding a t the margins but no ulceration. Tonsils large and inflamed. Submaxillary and upper jugular glands considerably cnlarged on both sides, falrly firm, mobile and slightly tender. Spleen and liver not demonstrably enlarged. Thore wore no subcutaneous nor submucous haemorrhagos. Tongue moist and coated with a thick brown fur. A few caxious teeth. A trace of A tall well-built man with a sallow unhealthy complexion. 61 7 618 A . C. P. CAMPBELL, J . L. HENDERSON A N D J. H . GROOM albumin in the urine. and ncrvous systems normal. the striking feature wm the leucocytosis with monocytic predominance.A mitral systolic murmur was present. RespiratoryThe blood findings are recorded in table I ; Progreaa notes. The scvcre headache subsided in a fortnight, but the anEmia steadily progressed, becoming definitely mcgalocytic in type. The white blood count fell gradually towards normal but tho qualitative alteration persisted. The swelling of the gums increased until the teeth were almost buried. The tcmperaturu fluctuated between normal and 1003 F.After ten weeks, a spontaneous remission set in ; the temperature became normal and the swelling of the gums deoreased. The anaemia improved and the white blood picture became almost normal apart from a leucopenia with a relative lymphocytosis. The patient gained rapidly in strength and weight and was discharged to a convalescent home. Improvement seemed t o continue for several weeks thereafter, until nausea and abdominal pain drew attention to a large, firm, slightly tendcr maw in the right iliac fossn. Two weeks later he was readmitted to hospital, the mass being still present. Tho swelling steadily diminished...

Leukaemic lesions of the gastrointestinal tract

“…plaque of acute myeloid leukaemia in the terminal ileum. Campbell, Henderson, and Croom (1936) describe an 8 cm. plaque of monocytic leukaemia in the lower third of the rectum.…”

In vitro genotoxicity of exhaust emissions of diesel and gasoline engine vehicles operated on a unified driving cycle

“…2,15 While in vitro bioassays of organic solvent extracts of DEP appear not to model the biological availability in the lung of DEP-bound organic genotoxicants, 16 it has been demonstrated that DEP can express in vitro genotoxic activities as non-extracted parti-culate dispersions in the primary components of the surfactants which line the lung small airways and airspaces. [17][18][19][20][21] Gasoline engine exhaust genotoxicities have been studied since the 1930s; 22 however, the literature is not as extensive as that for diesel engine emissions. 2 Bacterial mutagenicity for gasoline exhaust has been reviewed by Claxton, 23 and shortterm bioassay results have been reviewed by Lewtas.…”