Monocytic parameters in patients with dysthymia versus major depression

Schlatter, Javier; Ortuño, Felipe; Cervera-Enguix, Salvador

doi:10.1016/s0165-0327(02)00316-6

Cited by 40 publications

(30 citation statements)

References 22 publications

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“…Inflammation in depression has been studied in depth by various other authors. They discussed increased proinflammatory cytokines, increased acute-phase proteins, and increased expression of chemokines and adhesion molecules in depressive patients [45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61]. In relation to depressed patients, increased levels of IL-1-β and TNF-α have also been found in the peripheral blood circulation and in the cerebrospinal fluid [62,63,64,65].…”

Section: Systemic Immunological Changes In Major Depressionmentioning

confidence: 99%

Major Depression and Psoriasis: A Psychodermatological Phenomenon

Tohid¹,

Aleem²,

Jackson³

2016

Skin Pharmacol Physiol

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Objective: The aim of this paper was to highlight the mechanisms involved and the relationship between depression and psoriasis. Method: A comprehensive literature search was performed in various databases, and finally 88 studies were deemed relevant. Results: A significant link was found between depression and psoriasis, primarily through immune mechanisms related but not limited to the actions of inflammatory cytokines such as tumor necrosis factor-α, interleukin 1 (IL-1), IL-2, IL-10, interferon-γ, IL-1β, prostaglandin E2, C-reactive protein, IL-6, and IL-8. Conclusion: Various neuroimmunological studies point towards the notion that depression and psoriasis are associated with each other. Melatonin has also been found to be associated with both conditions. A possibility exists that both conditions can cause each other due to the possible bidirectional relationship of psoriasis and major depression. However, if this is the case, then why all depressed patients fail to develop psoriasis and why all psoriatic patients fail to develop depression remains a question unanswered. We believe that future studies will unmask this mystery.

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Section: Systemic Immunological Changes In Major Depressionmentioning

confidence: 99%

Major Depression and Psoriasis: A Psychodermatological Phenomenon

Tohid¹,

Aleem²,

Jackson³

2016

Skin Pharmacol Physiol

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“…The mean plasma IL-6 level of depressive subjects (1.75 pg/ml) was significantly higher than in the normal donor subjects (0.2 pg/ml; p<0.05) (Figure 1). It has been shown that IL-6 can be higher in the depression patients when compared to the healthy subjects (Frommenberger et al, 1997;Lin et al, 1998;Schlatter et al 2004). The present results were, therefore, compatible with the previous findings.…”

Section: Resultsmentioning

confidence: 99%

Higher than normal plasma Iinterleukin-6 concentrations in brazilian patients with mood disorders

Miranda

Nunes

Reiche

et al. 2011

Braz. arch. biol. technol.

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“…Clinical and experimental depression has been associated with activation and inactivation of the immune system [1][2][3][4][5][6][7][8] . A substantial body of evidence indicates that dysregulation of the immune system is associated with major depressive disorder.…”

Section: Discussionmentioning

confidence: 99%

Forced Swimming Test Decreases Chemotactic Responsiveness and Expression of CD11a in Rat Monocytes

Briceño

Arcaya

Carrizo

et al. 2010

Neuroimmunomodulation

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Objectives: Previous reports have shown that the depressive status in humans and experimental animals is associated with decreased immune response. Since monocyte chemotaxis and expression of CD11a are pivotal mechanisms in immune response, impairment of these events could explain the diminished immune response in depression. Methods: To test this, rats were submitted to the forced swimming test (FST) for 3 and 15 days. Animals were sacrificed at days 4 (3 days’ FST), 16 (15 days’ FST) and 30 (15 days’ FST and 15 days of recovery time). At these times, a blood sample was obtained for serum and leukocyte isolation. Mononuclear leukocytes were obtained by Histopaque gradient. Chemotaxis responsiveness was determined in Boyden chambers using zymosan-activated rat serum. Cellular CD11a expression and serum CD11a were determined by immunofluorescence and ELISA, respectively. Results: Decreased chemotaxis was observed in FST animals at days 4 and 16 with total recovery at day 30. Diminished expression of cellular CD11a was observed at day 16 and remained decreased at day 30. There were no significant differences in serum CD11a content. Conclusion: Decreased chemotactic response and expression of CD11a found in this experimental model of depression could be important mechanisms to induce impairment immune response in experimental and clinical depression.

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Monocytic parameters in patients with dysthymia versus major depression

Cited by 40 publications

References 22 publications

Major Depression and Psoriasis: A Psychodermatological Phenomenon

Major Depression and Psoriasis: A Psychodermatological Phenomenon

Higher than normal plasma Iinterleukin-6 concentrations in brazilian patients with mood disorders

Forced Swimming Test Decreases Chemotactic Responsiveness and Expression of CD11a in Rat Monocytes

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