Monocytosis in Malignant Disease

Barrett, O'Neill

doi:10.7326/0003-4819-73-6-991

Cited by 50 publications

(11 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dysplasia of the bone marrow accompanying malignant processes has been documented [9][10][11]. The persistent monocytosis in our pa tient, observed also in other cases of malignant diseases [11,12], supports the etiological role of the malignant tu mor in the development of the myelokathexis.…”

Section: Discussionsupporting

confidence: 57%

Myelokathexis and Monocytosis in a Patient with Gastric Cancer

Maran¹,

Mittelman²,

Cohen³

et al. 1992

Acta Haematol

View full text Add to dashboard Cite

A 66-year-old patient developed leukocytosis, neutrophilia and monocytosis following surgery for gastric carcinoma. The polymorphonuclear cells showed a marked shift to the right and abnormally hypersegmented or pyknotic nuclei, whereas the monocytes were vacuolized. The bone marrow was hypercellular with an increased number of multilobed polymorphonuclear cells. This myeloid cell defect is compatible with the nuclear abnormalities described as myelokathexis. The combination of the nuclear abnormalities of the polymorphonuclear cells with persistent monocytosis suggests the possibility of a paraneoplastic variant of myelodysplasia.

show abstract

Section: Discussionsupporting

confidence: 57%

Myelokathexis and Monocytosis in a Patient with Gastric Cancer

Maran¹,

Mittelman²,

Cohen³

et al. 1992

Acta Haematol

View full text Add to dashboard Cite

show abstract

“…Golde et al (1978) have shown that at a physiological concentration (0.1ng/ml), HCS has a direct effect on the in vitro proliferation of murine erythroleukemia cells and a direct action on mammalian cells. In man, a mild to marked increase in granulocytes and monocytes has been observed in various types of neoplasms, in the absence of infection (Barrett, 1970). Whether production of ectopic proteins or other hormones by tumor cells is involved in these change remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Effects of a placental hormone, human chorionic somatomammotropin on normal and malignant cells.

Mukherjee¹,

Das²

1984

Endocrinol Japon

View full text Add to dashboard Cite

show abstract

“…Die wichtigsten Ver/inderungen, die sich bei 1/ingerw/ihrenden Tumorleiden regelmfil3ig einstellen, sind Leukozytose (Grimm et al 1985), Monozytose (Barrett 1970), Thrombozytose (Schneider t987b) und Hyperkoagulabilitfitssyndrom (Hirsh 1977) mit Fibrinogenerh6hung, Faktor VIII-Vermehrung, Vermehrung anderer Gerinnungsfaktoren und Plasmaproteine (Rickles und Edwards 1983), sowie Aktivierung des Immunsystems. Die dabei zustandekommende Fibrinogenerh6hung und Dysproteinfimie ist die Ursache f/ir die allm/ihlich zunehmende Senkungsbeschleunigung, deren Abh/ingigkeit vom Fibrinogenspiegel seit langem bekannt ist (Schneider und Kliche 1987).…”

Section: Im Sp~iteren Krankheitsverlauf Auftretende H~imatologisch-h~unclassified

“…Wahrscheinlich geht also die Monozytenreaktion (Barrett 1970) allen anderen Verfinderungen, einschliel31ich der reaktiven Leukozytose mit Linksverschiebung, als Prim/irreaktion voraus (Abb. 1).…”

Section: Bedeutung Des Monozyten-makrophagen-systemsunclassified

Hämatologische oder hämostaseologische „Paraneoplasien“ als Prognosefaktoren?

Schneider

1988

Klin Wochenschr

View full text Add to dashboard Cite

Paraneoplastic syndromes are early but seldom appearing remote effects of tumors. In contrast, hematological or hemostaseological tumor signs can be demonstrated nearly in every tumor patient, mostly, however, after prolonged disease. The signs result from interaction between tumor and host, they depend upon the monocyte-macrophage system and are mediated by interleukin-1. Therefore, strictly speaking, they are no paraneoplasias. By genetic instability and increasing heterogeneity, the tumor cell gradually overcomes this defence line and the clinical pictures of different metastatic diseases equalize slowly. Finally, main causes of death are equally occurring infectious and hemostaseological complications. They demonstrate the final breakdown of this defence system.

show abstract

Monocytosis in Malignant Disease

Cited by 50 publications

References 4 publications

Myelokathexis and Monocytosis in a Patient with Gastric Cancer

Myelokathexis and Monocytosis in a Patient with Gastric Cancer

Effects of a placental hormone, human chorionic somatomammotropin on normal and malignant cells.

Hämatologische oder hämostaseologische „Paraneoplasien“ als Prognosefaktoren?

Contact Info

Product

Resources

About