Monofloral honey from a medical plant,<i>Prunella Vulgaris</i>, protected against dextran sulfate sodium-induced ulcerative colitis<i>via</i>modulating gut microbial populations in rats

Wang, Kai; Wan, Zhengrui; Ou, Aiqun; Liang, Xinwen; Guo, Xiaoxuan; Zhang, Zhong-Yin; Wu, Liming; Xue, Xiao‐Feng

doi:10.1039/c9fo00460b

Cited by 109 publications

(86 citation statements)

References 44 publications

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“…The underlying mechanisms are that sebocytes can be recognized and activated by P. acnes , which further trigger the release of inflammatory cytokines [ 39 ]. TNF- α is an extensively studied cytokine associated with many inflammatory diseases [ 40 ]. Evidences indicated that IL-1 α is one of the main inflammatory factors, which could induce the proliferation of keratinocytes and sebaceous gland cells and eventually promote the formation of acne vulgaris [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Essential Oil and Juice from Bergamot and Sweet Orange Improve Acne Vulgaris Caused by Excessive Androgen Secretion

Sun

Zhao

Zhang

et al. 2020

Mediators of Inflammation

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Acne vulgaris is one of the most common chronic inflammatory skin diseases. Bergamot and sweet orange are rich in nutritional and functional components, which exhibit antioxidant, anti-inflammatory, and antiapoptotic effect. The aim of this study was to evaluate the potential effect of bergamot and sweet orange (juice and essential oil) on acne vulgaris caused by excessive secretion of androgen. Eighty male golden hamsters were randomly divided into 10 groups and received low or high dose of bergamot and sweet orange juice and essential oil, physiological saline, and positive drugs for four weeks, respectively. Results showed that all interventions could improve acne vulgaris by reducing the growth rate of sebaceous gland spots, inhibiting TG accumulation, decreasing the release of inflammatory cytokines (notably reducing IL-1α levels), promoting apoptosis in the sebaceous gland, and decreasing the ratio of T/E2. Among them, bergamot and orange essential oil may have better effects (dose dependent) on alleviating acne vulgaris than the corresponding juice. In view of the large population of acne patients and the widespread use of sweet orange and bergamot, this study is likely to exert an extensive and far-reaching influence.

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Section: Discussionmentioning

confidence: 99%

Essential Oil and Juice from Bergamot and Sweet Orange Improve Acne Vulgaris Caused by Excessive Androgen Secretion

Sun

Zhao

Zhang

et al. 2020

Mediators of Inflammation

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“…The intestinal barriers are important for the body's resistance to external pathogens and toxins, inflammation, stress, surgical trauma, and hypovolemia; however, ischemia-reperfusion injury can cause intestinal barrier damage [93,94]. Thus, bacteria and toxins in the intestine can reach the mesenteric lymphoid tissues, lymph fluid, blood, and extraintestinal tissues and organs, causing gut-derived sepsis and eventually leading to multiple organ dysfunction syndrome (MODS) [95].…”

Section: Intestinal Protectionmentioning

confidence: 99%

Organ-Protective Effects and the Underlying Mechanism of Dexmedetomidine

Bao

Tang

2020

Mediators of Inflammation

112

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Dexmedetomidine (DEX) is a highly selective α2 adrenergic receptor (α2AR) agonist currently used in clinical settings. Because DEX has dose-dependent advantages of sedation, analgesia, antianxiety, inhibition of sympathetic nervous system activity, cardiovascular stabilization, and significant reduction of postoperative delirium and agitation, but does not produce respiratory depression and agitation, it is widely used in clinical anesthesia and ICU departments. In recent years, much clinical study and basic research has confirmed that DEX has a protective effect on a variety of organs, including the nervous system, heart, lungs, kidneys, liver, and small intestine. It acts by reducing the inflammatory response in these organs, activating antiapoptotic signaling pathways which protect cells from damage. Therefore, based on wide clinical application and safety, DEX may become a promising clinical multiorgan protection drug in the future. In this article, we review the physiological effects related to organ protection in α2AR agonists along with the organ-protective effects and mechanisms of DEX to understand their combined application value.

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“…Anthocyanins have been reported to increase the relative abundance of beneficial bacteria such as Bifidobacterium and Akkermansia, which are believed to be closely related to anti-inflammatory effects [24,65]. Monofloral honey from Prunella Vulgaris, rich in PCA, VA, and FA, showed protective effects against dextran sulfate sodium-induced ulcerative colitis in rats potentially through restoring the relative abundance of Lactobacillus [66]. Our previous studies also found that the Lonicera caerulea L. berry rich in C3G could attenuate inflammation potentially through the modulation of gut microbiota, especially the ratio of Firmicutes to Bacteroidetes in a mouse model of experimental non-alcoholic fatty liver disease [67].…”

Section: Crosstalk Between Gut Microbiota and C3gandc3g-msmentioning

confidence: 99%

The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity

et al. 2019

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Cyanidin-3-glucoside (C3G) is a well-known natural anthocyanin and possesses antioxidant and anti-inflammatory properties. The catabolism of C3G in the gastrointestinal tract could produce bioactive phenolic metabolites, such as protocatechuic acid, phloroglucinaldehyde, vanillic acid, and ferulic acid, which enhance C3G bioavailability and contribute to both mucosal barrier and microbiota. To get an overview of the function and mechanisms of C3G and its phenolic metabolites, we review the accumulated data of the absorption and catabolism of C3G in the gastrointestine, and attempt to give crosstalk between the phenolic metabolites, gut microbiota, and mucosal innate immune signaling pathways.

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Monofloral honey from a medical plant,Prunella Vulgaris, protected against dextran sulfate sodium-induced ulcerative colitisviamodulating gut microbial populations in rats

Abstract: Honey produced from medicinal plants hold great promise for human gut health.

Cited by 109 publications

References 44 publications

Essential Oil and Juice from Bergamot and Sweet Orange Improve Acne Vulgaris Caused by Excessive Androgen Secretion

Essential Oil and Juice from Bergamot and Sweet Orange Improve Acne Vulgaris Caused by Excessive Androgen Secretion

Organ-Protective Effects and the Underlying Mechanism of Dexmedetomidine

The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity

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