Monofluorophosphate Utilization in Oral Preparations: Laboratory Observations

Mellberg, J.R.

doi:10.1159/000260732

Cited by 6 publications

(7 citation statements)

References 24 publications

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“…1, 3) is relevant and it is noteworthly that when the total fluoride content of the NaMFP samples is considered, only the post-rinse NaF 120-min plaque fluid values are statistically greater than the corresponding NaMFP values. Although the second mechanism is usually considered with respect to the calcium and phosphate content of the dentifrice abrasive [Mellberg, 1983;DePaola, 1993;Sullivan et al, 1997], a more important consideration may be the interaction between MFP and the high concentrations of calcium and phosphate present in the oral environment and more particularly where this interaction occurs. Specifically, following a NaMFP rinse, the interaction of these ions with the fluoride ion, which causes the formation of CaF 2 or fluorapatite precipitates, would only occur after MFP hydrolysis within the plaque or in the enamel pores where such mineral phases would be of maximum benefit.…”

Section: Discussionmentioning

confidence: 99%

Fluoride in Plaque Fluid, Plaque, and Saliva Measured for 2 hours after a Sodium Fluoride Monofluorophosphate Rinse

Vogel

Y²,

Chow³

et al. 2000

Caries Res

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Sodium monofluorophosphate (NaMFP) and sodium fluoride (NaF) are the two most common sources of fluoride used in currently marketed fluoride dentifrices. The purpose of this study was to investigate the effect of mouth rinses containing NaF or NaMFP on the concentrations of fluoride, or the MFP ion, in saliva, whole plaque, and plaque fluid. Twelve subjects abstained from tooth brushing for 48 h, fasted overnight, and then rinsed 1 min with 12 mmol/l (228 ppm [μg/g] F) NaF or NaMFP in the morning. Before the rinse and at 30, 60 and 120 min afterwards, upper and lower molar and premolar plaque samples and whole saliva samples were collected. Aliquots of plaque fluid and centrifuged saliva were obtained from these samples, and the whole plaque residue acid extracted. The F and MFP concentrations were then measured in these samples using ultramicro methods. For both rinses, a higher concentration of plaque fluid fluoride was found at lower molar sites while the reverse was true for the whole plaque fluoride. Furthermore, for both rinses, plaque fluid, whole plaque, but not salivary, fluoride concentrations were above baseline at 120 min. Following the NaMFP rinse, a substantial amount of unhydrolyzed MFP was found in plaque fluid and saliva. Although there was a very large range in these measurements, fluoride in plaque fluid (excluding fluoride in unhydrolyzed MFP) and whole plaque were significantly (p<0.05) greater after the NaF rinse at all time periods. In saliva, the NaF rinse produced a statistically significant greater salivary fluoride (excluding fluoride in unhydrolyzed MFP) only at 60 min. The lack of a clear correlation between these measurements and clinical studies suggest a novel mechanism may enhance the effectiveness of NaMFP dentifrices.

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Section: Discussionmentioning

confidence: 99%

Fluoride in Plaque Fluid, Plaque, and Saliva Measured for 2 hours after a Sodium Fluoride Monofluorophosphate Rinse

Vogel

Y²,

Chow³

et al. 2000

Caries Res

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“…Mellberg and Chomicki [1983] have reported similar flu oride uptakes by artificial carious lesions in vivo from a NaF dentifrice compared to a NaoPO^F dentifrice. Mellberg [1983] fur ther argues that when fluoride uptake experiments are conducted in vivo, realis tically duplicating the conditions under which the products are used, NaF and NaiPOjF should deposit similar amounts of fluoride into demineralized enamel since a large part of the Na2PC>3F is rap idly hydrolyzed to ionic fluoride by phos phatases present in the mouth. Forward [1980] has observed that the effect of fluo ride on the acid dissolution rate of enamel is related to the logarithm of the fluoride ion concentration.…”

Section: Discussionmentioning

confidence: 99%

Clinical Comparison of the Caries Inhibition of Two Mixed NaF-Na₂PO₃F Dentifrices Containing 1,000 and 2,500 ppm F Compared to a Conventional Na₂PO₃F Dentifrice Containing 1,000 ppm F: Results after Two Years

Ripa¹,

Leske²,

Sposato³

et al. 1987

Caries Res

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The 2-year caries increments of fifth to seventh grade students (mean age 11.7 years) residing in two fluoride-deficient communities (F < 0.1 ppm) on Long Island, N.Y., were compared relative to their use of different fluoride dentifrices. Group I used a conventional Na₂PO₃F dentifrice (1,000 ppm F) and served as the positive control. Group II used a mixed fluoride dentifrice containing equimolar amounts of NaF and Na₂PO₃F which provided a total fluoride concentration of 1,000 ppm. Group III also used a mixed fluoride dentifrice containing equimolar amounts of NaF and Na₂PO₃F with a total fluoride concentration of 2,500 ppm. Brushing was performed unsupervised at home for 23 months. There were no statistically significant differences (F test) in the 2-year caries increments between the dentifrice groups for DMFT, DMFS, and DMFS of specific tooth surface types. Mitigating factors which may have influenced the results were the low proximal caries increments and the degree of compliance. Use of a mixed fluoride dentifrice (NaF/Na₂PO₃F) at a standard 1,000 ppm F concentration or at 2.5 times standard did not provide superior caries inhibition compared to a conventional Na₂PO₃F dentifrice containing 1,000 ppm F.

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“…However, recent investigations revealed that demineralized enamel takes up more fluoride from MFP preparations than does sound enamel (Mellberg, 1980;Klimek, 1981). Increased F-uptake by demineralized enamel or hydrolysis of MFP by plaque bacteria may be the possible reasons for the fact that MFP is equally as effective as other fluorides in preventing dental caries (Mellberg, 1983).…”

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confidence: 99%

The Influence of Plaque on Reaction Mechanism of MFP and NaF in vivo

1987

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A modified Intra-oral Cariogenicity Test was used to study the influence of plaque on the reaction mechanism of sodium monofluorophosphate (MFP) or sodium fluoride (NaF) in either sound or demineralized enamel in vivo. Volunteer students, wearing mouth appliances holding enamel blocks, rinsed their mouths with MFP or NaF solution (1,000 ppm F-) three times a day. The amount of loosely-bound and acquired fluoride was determined after an experimental period of five days in plaque-covered, demineralized (PCD); clean, demineralized (CD); plaque-covered, sound (PCS); and clean sound enamel (CS). While no measurable loosely-bound fluoride could be found after MFP treatment, NaF caused deposition of a significant amount of alkali-soluble fluoride in all experimental groups. After MFP rinses, fluoride concentration in the enamel was increased in the following order: CS, PCS, CD, and PCD. After NaF treatment, demineralized enamel exhibited a higher fluoride acquisition when compared with sound enamel. Plaque had a minor effect on F- acquisition. It is concluded that demineralization of enamel enhances F- uptake from both NaF and MFP solutions. In the presence of plaque, F- acquisition was additionally increased only after MFP rinses in vivo.

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Monofluorophosphate Utilization in Oral Preparations: Laboratory Observations

Cited by 6 publications

References 24 publications

Fluoride in Plaque Fluid, Plaque, and Saliva Measured for 2 hours after a Sodium Fluoride Monofluorophosphate Rinse

Fluoride in Plaque Fluid, Plaque, and Saliva Measured for 2 hours after a Sodium Fluoride Monofluorophosphate Rinse

Clinical Comparison of the Caries Inhibition of Two Mixed NaF-Na₂PO₃F Dentifrices Containing 1,000 and 2,500 ppm F Compared to a Conventional Na₂PO₃F Dentifrice Containing 1,000 ppm F: Results after Two Years

The Influence of Plaque on Reaction Mechanism of MFP and NaF in vivo

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Monofluorophosphate Utilization in Oral Preparations: Laboratory Observations

Cited by 6 publications

References 24 publications

Fluoride in Plaque Fluid, Plaque, and Saliva Measured for 2 hours after a Sodium Fluoride Monofluorophosphate Rinse

Fluoride in Plaque Fluid, Plaque, and Saliva Measured for 2 hours after a Sodium Fluoride Monofluorophosphate Rinse

Clinical Comparison of the Caries Inhibition of Two Mixed NaF-Na2PO3F Dentifrices Containing 1,000 and 2,500 ppm F Compared to a Conventional Na2PO3F Dentifrice Containing 1,000 ppm F: Results after Two Years

The Influence of Plaque on Reaction Mechanism of MFP and NaF in vivo

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Clinical Comparison of the Caries Inhibition of Two Mixed NaF-Na₂PO₃F Dentifrices Containing 1,000 and 2,500 ppm F Compared to a Conventional Na₂PO₃F Dentifrice Containing 1,000 ppm F: Results after Two Years