Monolayers of the lipid derivatives of isoniazid at the air/water interface and the formation of self-assembled nanostructures in water

Jin, Yiguang; Chen, Shufeng; Xin, Rui; Yi-sheng, Zhou

doi:10.1016/j.colsurfb.2008.01.023

Cited by 23 publications

(11 citation statements)

References 25 publications

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“…Flexible medium-long tails formed self assembling nano-sized vesicles whereas short lipid tail-derivatives resulted in weak hydrophobic interactions. Lipid vesicles showed increased penetration of the drug into the pathogen leading to promising antibacterial activity against Mycobacterium [89].…”

Section: Inh-poly(ethyleneglycol)-poly(aspartic Acid)mentioning

confidence: 99%

Present status of nanoparticle research for treatment of Tuberculosis

2011

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-Nanotechnology has offered enormous improvement in field of therapeutics by means of designing of drug delivery systems and opened the possibility of controlling infections at the molecular level. Nanocarriers can cross biological barriers and are able to target cellular reservoirs of Mycobacterium tuberculosis (M. tuberculosis). Nanoparticle-based systems have significant potential for treatment and prevention of tuberculosis (TB). A variety of nanocarriers have been widely evaluated as potential drug delivery systems for various administration routes. Targeting the drugs to certain physiological sites such as the lymph nodes has emerged as a promising strategy in treating TB with improved drug bioavailability and reduction of the dosing frequency. Nanotechnology based rational targeting may improve therapeutic success by limiting adverse drug effects and requiring less frequent administration regimes, ultimately resulting in more patients compliance and thus attain higher adherence levels. The development of nanoparticle based aerosol vaccine is undergoing which could serve as new platform for immunization. Present article compiles the general physiological aspects of the infection along with new research uptades on nanocarriers used in prevention of tuberculosis. _______________________________________________________________________________________

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Section: Inh-poly(ethyleneglycol)-poly(aspartic Acid)mentioning

confidence: 99%

Present status of nanoparticle research for treatment of Tuberculosis

2011

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“…Moreover, a stronger antimycobacterial activity was apparent. To overcome resistance, Jin and collaborators designed INH lipid derivatives [48]. The new amphiphilic molecules formed monolayers at the air/water interface.…”

Section: Polymeric Micellesmentioning

confidence: 99%

Nanotechnology: A focus on Treatment of Tuberculosis.

Kumar¹,

Kumar²,

Kumar³

et al. 2011

Int J Drug Del

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Despite the fact that we live in an era of advanced technology and innovation, infectious diseases, like Tuberculosis (TB), continue to be one of the greatest health challenges worldwide. The main drawbacks of conventional TB treatment are the development of multiple drug resistance, resulting in high dose requirements and subsequent intolerable toxicity. Therefore there is a need of a new system have been receiving special attention with the aim of minimizing the side effects of drug therapy, such as poor bioavailability and the selectivity of drugs. Nanoparticle-based drug delivery systems have considerable potential for treatment of TB. The important technological advantages of nanoparticles used as drug carriers are high stability, high carrier capacity, feasibility of incorporation of both hydrophilic and hydrophobic substances, and feasibility of variable routes of administration, including oral application and inhalation. Nanoparticles can also be designed to allow controlled (sustained) drug release from the matrix. These properties of nanoparticles enable improvement of drug bioavailability and reduction of the dosing frequency, and may resolve the problem of nonadherence to prescribed therapy, which is one of the major obstacles in the control of TB epidemics. In this review, we discuss the challenges with the current treatment of the disease and shed light on the remarkable potential of nanotechnology to provide more effective treatment and prevention for TB.

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“…Molecular self-assembly behavior of amphiphiles in aqueous media usually agrees with their monolayer behavior [32,33]. CAD owns a flexible tail, favoring to form flexible bilayers and stable spherical vesicles in water by itself, although CSD has to keep the flexible bilayers with the help of THF.…”

Section: Effect Of Spacer Length On the Morphology Of Self-assembled mentioning

confidence: 71%