Monolithic Integration of Vertical Thin-Film Transistors in Nanopores for Charge Sensing of Single Biomolecules

Zhu, Xiaoqin; Li, Xiaojie; Gu, Chaoming; Yang, Zhi; Cao, Zhen; Zhang, Xingye; Jin, Chuanhong; Liu, Yang

doi:10.1021/acsnano.1c01042

Cited by 16 publications

(16 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To fully exploit this result, it is necessary to utilise alternative sensing mechanisms to ionic current based detection that do not require individual nanopores to be fluidically isolated for their signal to be read out independently. Such alternative readout mechanisms often rely on integrating on-chip nanostructures such as fieldeffect sensors [18][19][20][21][22], tunnelling nanogaps [23][24][25][26], plasmonic nanostructures [57,58], and radiofrequency antennas [59] with a nanopore. To address this, we extended our CBD strategy to fabricate nanopores that are self-aligned with on-chip nanoelectrodes.…”

Section: Self-aligning Nanopores With An On-chip Metal Nanoconstrictionmentioning

confidence: 99%

“…In particular, electrodes embedded within, or in close proximity to a nanopore can be used to control the translocation dynamics of biomolecules [13][14][15][16] or enable dielectrophoretic concentrating of analytes at the nanopore opening [17]. Solid-state nanopores have also been integrated with field-effect sensors [18][19][20][21][22] and tunnelling nanogap electrodes [23][24][25][26][27]. Measuring the conduction through such nanoelectrodes provides an alternative readout mechanism to ionic current based detection.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Localised solid-state nanopore fabrication via controlled breakdown using on-chip electrodes

et al. 2022

View full text Add to dashboard Cite

Controlled breakdown has recently emerged as a highly accessible technique to fabricate solid-state nanopores. However, in its most common form, controlled breakdown creates a single nanopore at an arbitrary location in the membrane. Here, we introduce a new strategy whereby breakdown is performed by applying the electric field between an on-chip electrode and an electrolyte solution in contact with the opposite side of the membrane. We demonstrate two advantages of this method. First, we can independently fabricate multiple nanopores at given positions in the membrane by localising the applied field to the electrode. Second, we can create nanopores that are self-aligned with complementary nanoelectrodes by applying voltages to the on-chip electrodes to locally heat the membrane during controlled breakdown. This new controlled breakdown method provides a path towards the affordable, rapid, and automatable fabrication of arrays of nanopores self-aligned with complementary on-chip nanostructures.

show abstract

Section: Self-aligning Nanopores With An On-chip Metal Nanoconstrictionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Localised solid-state nanopore fabrication via controlled breakdown using on-chip electrodes

et al. 2022

View full text Add to dashboard Cite

show abstract

“…To fully exploit this result, it is necessary to utilise alternative sensing mechanisms to ionic current based detection that do not require individual nanopores to be fluidically isolated for their signal to be read out independently. Such alternative readout mechanisms often rely on integrating on-chip nanostructures such as field-effect sensors [18][19][20][21][22] , tunnelling nanogaps [23][24][25][26] , plasmonic nanostructures 54,55 , and radiofrequency antennas 56 with a nanopore. To address this, we extended our CBD strategy to fabricate nanopores that are self-aligned with on-chip nanoelectrodes.…”

Section: Self-aligning Nanopores With An On-chip Metal Nanoconstrictionmentioning

confidence: 99%

“…In particular, electrodes embedded within, or in close proximity to a nanopore can be used to control the translocation dynamics of biomolecules [13][14][15][16] or enable dielectrophoretic concentrating of analytes at the nanopore opening 17 . Solid-state nanopores have also been integrated with field-effect sensors [18][19][20][21][22] and tunnelling nanogap electrodes [23][24][25][26][27] . Measuring the conduction through such nanoelectrodes provides an alternative readout mechanism to ionic current based detection.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Localised Solid-State Nanopore Fabrication via Controlled Breakdown using On-Chip Electrodes

Fried,

Swett,

Nadappuram

et al. 2021

Preprint

View full text Add to dashboard Cite

Controlled breakdown has recently emerged as a highly accessible technique to fabricate solidstate nanopores. However, in its most common form, controlled breakdown creates a single nanopore at an arbitrary location in the membrane. Here, we introduce a new strategy whereby breakdown is performed by applying the electric field between an on-chip electrode and an electrolyte solution in contact with the opposite side of the membrane. We demonstrate two advantages of this method. First, we can independently fabricate multiple nanopores at given positions in the membrane by localising the applied field to the electrode. Second, we show we can create nanopores that are self-aligned with complementary nanoelectrodes by applying voltages to the on-chip electrodes to locally heat the membrane during controlled breakdown. This new controlled breakdown method provides a path towards the affordable, rapid, and automatable fabrication of arrays of nanopores self-aligned with complementary on-chip nanostructures.Solid-state nanopore devices have received interest in recent years for applications ranging from protein analysis 1-3 , to polymer data storage 4,5 , and ultra-dilute analyte detection 6-9 . These devices typically consist of a nanometre-scale hole in a synthetic material that separates two chambers of electrolyte solution. When a voltage is applied across the membrane, ions flow through the nanopore resulting in a measurable ionic current. Sensing is then typically achieved by detecting changes in the ionic current as an analyte translocates through the pore and modifies the flow of ions [10][11][12] .

show abstract

Field‐Effect Transistor‐Based Biosensor for pH Sensing and Mapping

Ren

Liang

et al. 2023

Advanced Sensor Research

View full text Add to dashboard Cite

It is vital to acquire real‐time pH signals with high resolution as pH variation can reflect important information regarding health status and physiological environment. Field‐effect transistor (FET)‐based biosensors (bio‐FETs), a kind of potentiometric sensor, are being rapidly developed for pH detection due to their advantages of high sensitivity, low temperature dependence, and high portability. More importantly, the high scalability of bio‐FETs renders them applicable for achieving high spatial resolution in pH sensing. In this review paper, the design, operation principle, and critical characteristics of the FET‐based pH sensor are introduced. Then, the recent progress in pH mapping with FET sensor arrays, including static array where a sensor pixel is directly addressed by wiring, and active‐matrix array where a sensor pixel is accessed by additional switching FETs, is presented. Last, typical examples of pH sensor arrays in biomedical applications, such as health monitoring and DNA sequencing and elongation are presented.

show abstract

Monolithic Integration of Vertical Thin-Film Transistors in Nanopores for Charge Sensing of Single Biomolecules

Cited by 16 publications

References 38 publications

Localised solid-state nanopore fabrication via controlled breakdown using on-chip electrodes

Localised solid-state nanopore fabrication via controlled breakdown using on-chip electrodes

Localised Solid-State Nanopore Fabrication via Controlled Breakdown using On-Chip Electrodes

Field‐Effect Transistor‐Based Biosensor for pH Sensing and Mapping

Contact Info

Product

Resources

About