2017
DOI: 10.1038/srep43519
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Monomeric, porous type II collagen scaffolds promote chondrogenic differentiation of human bone marrow mesenchymal stem cells in vitro

Abstract: Osteoarthritis (OA) is a common cause of pain and disability and is often associated with the degeneration of articular cartilage. Lesions to the articular surface, which are thought to progress to OA, have the potential to be repaired using tissue engineering strategies; however, it remains challenging to instruct cell differentiation within a scaffold to produce tissue with appropriate structural, chemical and mechanical properties. We aimed to address this by driving progenitor cells to adopt a chondrogenic… Show more

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Cited by 91 publications
(74 citation statements)
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“…To successfully engineer cartilage‐like tissue using MSCs, it is critical to develop biomaterials that i) provide a microenvironment conducive to a stable chondrogenic phenotype, ii) provide mechanical integrity, and iii) possess the capacity to deliver growth factors and other regulatory biomolecules. In an effort to engineer cartilage‐mimetic biomaterials favorable to chondrogenesis, a number of studies have investigated the chondro‐inductivity of natural polymer scaffolds generated from and/or functionalized with commercially available collagens (typically type I or type II), hyaluronic acid, chondroitin sulfate and decellularized cartilage extracellular matrix (cECM) . While such ECM derived biomaterials are generally supportive of a chondrogenic phenotypic, they typically lack the mechanical properties for functioning in high load bearing environments.…”
Section: Introductionmentioning
confidence: 99%
“…To successfully engineer cartilage‐like tissue using MSCs, it is critical to develop biomaterials that i) provide a microenvironment conducive to a stable chondrogenic phenotype, ii) provide mechanical integrity, and iii) possess the capacity to deliver growth factors and other regulatory biomolecules. In an effort to engineer cartilage‐mimetic biomaterials favorable to chondrogenesis, a number of studies have investigated the chondro‐inductivity of natural polymer scaffolds generated from and/or functionalized with commercially available collagens (typically type I or type II), hyaluronic acid, chondroitin sulfate and decellularized cartilage extracellular matrix (cECM) . While such ECM derived biomaterials are generally supportive of a chondrogenic phenotypic, they typically lack the mechanical properties for functioning in high load bearing environments.…”
Section: Introductionmentioning
confidence: 99%
“…For cartilage, which has a very poor capacity for self-repair in the adult, much of what is known about the conditions that foster cartilage formation come from developmental studies, including the study of limb bud development and endochondral ossification in the axial skeleton. Cartilage TE strategies that mimic both the biochemical milieu as well as the mechanical environment that native cells experience during these developmental processes may yield engineered constructs that can repair damaged adult tissues [6] , [7] , [8] , [9] .…”
Section: Introductionmentioning
confidence: 99%
“…One of the characteristics of a good scaffold is it can provide en ough mechanical strength as an initial support for the neo-tissue formation [21]. This is perhaps due to the atelocollagen that promotes the secretion of collagen within the cells [22]. The secretion of ECM contributes to the mechanical strength of the scaffolds [19].…”
Section: Discussionmentioning
confidence: 99%