Monomethylarsonous acid binds to Cys-104α and Cys-112β of hemoglobin in acute promyelocytic leukemia patients treated with arsenic trioxide

Gao, Chunlu; Lin, Liwang; Li, Jing; Wu, Mengliang; Lv, Jian; Tian, Shu; Hai, Xin

doi:10.1016/j.toxlet.2023.04.001

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Applications: Clinical and Biological Materials1

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2024

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“…Last year 1 we commented on the potential teratogenicity of As 2 O 3 therapy in pregnant patients with acute promyelocytic leukaemia (APL). To further understand erythrocyte As accumulation in APL patients, binding mechanisms between different As species and Hb were investigated using SEC-ICP-MS. 213 Consistently with previous in vitro studies, MMA demonstrated higher binding affinity for Hb than DMA and iAs in erythrocytes from 9 APL patients treated with As 2 O 3 . Accurate mass TOF-MS analysis of MMA–Hb complexes confirmed Cys-104α and Cys-112β as the reactive binding sites for MMA.…”

Section: Applications: Clinical and Biological Materialssupporting

confidence: 91%