Mononeuropathy multiplex in association with livedoid vasculitis

Toth, Cory; Trotter, Martin J.; Clark, Arthur W.; Zochodne, Douglas W.

doi:10.1002/mus.10450

Cited by 33 publications

(47 citation statements)

References 43 publications

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“…Livedoid vasculitis is characterized by chronic recurrent painful and slowly healing ulcerations of the lower legs and feet leaving atrophic scars. Mostly sensory peripheral nerve involvement may occur, in particular multiplex neuropathy [95,97,108]. Moreover, 11 of 66 patients with CNS lupus were reported to present with livedoid vasculitis [110].…”

Section: ■ Anca-associated Vasculitismentioning

confidence: 99%

Intravenous immunoglobulin treatment in vasculitis and connective tissue disorders

Steinbrecher

Berlit

2006

J Neurol

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Vasculitis syndromes and connective tissue disorders are heterogeneous and mostly rare multisystem disorders with various autoimmune mechanisms driving tissue inflammation and remodeling, ischemic and hemorrhagic tissue damage. While the nervous system can be affected by most of these diseases, the pathogenesis for neural involvement is often ambiguous and elusive for the clinician. Intravenous immunoglobulins (IVIG) have been used for the treatment of most of these disorders. However, a thorough review of the literature indicates that the role for IVIG has to be discussed for individual entities, has often only anecdotal evidence, and is particularly hard to define with respect to neurological manifestations. This review gathers the available evidence on the efficacy of IVIG in neurologically relevant rheumatic diseases, leading to recommendations for their clinical use.

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Section: ■ Anca-associated Vasculitismentioning

confidence: 99%

Intravenous immunoglobulin treatment in vasculitis and connective tissue disorders

Steinbrecher

Berlit

2006

J Neurol

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“…A dor é um sintoma característico nos doentes, sendo que alguns deles podem apresentar um quadro de hiperestesias ou parestesias caracterizado como mononeurite múltipla. 11 Estudos demonstram que a coagulação alterada é um fator importante na patogênese da vasculopatia livedóide. 7 Atualmente, acredita-se que o principal mecanismo fisiopatogênico é um processo de vaso-oclusão decorrente da trombose de vasos dérmicos de pequenos e médios calibres; as alteracões inflamatórias são encontradas em lesões tardias e são considerados eventos secundários.…”

Section: Discussão E Conclusãounclassified

Livedoid vasculopathy: a clinical case proposition

Júnior

Cunha

Almeida

et al. 2017

Medicina (Ribeirão Preto)

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RESUMOA vasculopatia livedóide é uma dermatose crônica oclusiva dos vasos sanguíneos da derme, de caráter pauci-inflamatório ou não inflamatório, extremamente dolorosa. A etiologia não é totalmente esclarecida; estando associada a eventos pró-trombóticos. Caracterizada pela presença de lesões maculopapulares, eritêmato-purpúricas, nos membros inferiores, especialmente nos tornozelos e pés que ulceram gerando cicatrizes atróficas, denominadas atrofia branca. A histopatologia evidencia oclusão dos vasos da derme, devido à deposição de fibrina intravascular e presença de trombo intraluminal, além de hialinização segmentar e proliferação endotelial, há também, um infiltrado inflamatório perivascular discreto. Descrevemos um caso de vasculopatia livedóide evidenciando os achados histopatológicos encontrados na biópsia. Palavras ABSTRACTLivedoid vasculopathy is a chronic occlusive vasculopathy dermatosis, with a pauciinflammatory or noninflammatory characteristic, and is extremely painful. Its ethiology is not entirely known, being associated with pro-thrombotic events. Characterized by erythematous purpuric maculopapular lesions on the legs, especially on the ankles and feet, that ulcerates and heals with white atrophic scars, named atrophie blanche. Histopathology shows occlusion of dermal vases, segmental hyalinization and endothelial proliferation; there is also a discreet perivascular inflammatory infiltrate. We describe a case of livedoid vasculopathy showing the histopathological findings on the biopsy.

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“…Some patients experience symptoms of paresthesia or hyperesthesia, characterized as mononeuritis multiplex. 10 The involvement of the peripheral nervous system possibly occurs due to areas of multifocal ischemia, resulting from the deposition of fibrin and thrombin in the vasa nervorum. 10 The presence of varicose veins in patients with LV ranges from 20 to 75%, and purpura pigmentosa chronica may occur in about 20% of the patients, especially early in the development of the disease.…”

Section: Clinical Presentationmentioning

confidence: 99%

Vasculopatia livedoide: uma doença cutânea intrigante

Criado

Rivitti

Sotto

et al. 2011

An. Bras. Dermatol.

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Livedoid vasculopathy is a skin disease that occludes the blood vessels of the dermis. It has a pauciinflammatory or non-inflammatory nature. It is characterized by the presence of macular or papular, erythematous-purpuric lesions affecting the legs, especially the ankles and feet, and producing intensely painful ulcerations, which cause white atrophic scars called "atrophie blanche". This review includes studies and case reports found in the medical literature regarding the etiopathogenic associations of the disease, particularly those related to thrombophilia, their histopathological findings and the therapeutic approaches used in the difficult clinical management of these cases. Keywords: Leg ulcer; Livedo reticularis; Thrombophilia; Thrombosis; Venous thrombosis Resumo: A vasculopatia livedoide é uma afecção cutânea oclusiva dos vasos sanguíneos da derme, de caráter pauci-inflamatório ou não-inflamatório. Caracteriza-se pela presença de lesões maculosas ou papulosas, eritêmato-purpúricas, nas pernas, especialmente nos tornozelos e pés, as quais produzem ulcerações intensamente dolorosas, que originam cicatrizes atróficas esbranquiçadas, denominadas "atrofia branca". Nesta revisão, abordamos os estudos e relatos de caso da literatura médica referentes às associações etiopatogênicas da doença, particularmente as que se referem aos estados de trombofilia, seus achados histopatológicos e abordagens terapêuticas empregadas na difícil condução clínica destes casos.

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Mononeuropathy multiplex in association with livedoid vasculitis

Cited by 33 publications

References 43 publications

Intravenous immunoglobulin treatment in vasculitis and connective tissue disorders

Intravenous immunoglobulin treatment in vasculitis and connective tissue disorders

Livedoid vasculopathy: a clinical case proposition

Vasculopatia livedoide: uma doença cutânea intrigante

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