Mononuclear Transition Metal Complexes of 7‐Nitro‐1,3,5‐Triazaadamantane

Abstract

Abstract:Complexes of the type [MCl2(7-nitro-1,3,5-triaza-adamantane)2] (M = Zn(II), Pd(II), Pt(II)) and [MCl2(H2O)2(7-nitro-1,3,5-triazaadamantane)2] (M = Mn (II), Co(II), Ni(II)) have been prepared and their structures have been analysed by X-ray crystallography, elemental analysis, IR and solid state 13 C and 15 N NMR spectroscopy, supported by density functional theory/gauge independent atomic orbital (DFT/GIAO) calculations. In each case, 7-nitro-1,3,5-triazaadamantane acts as a mono-dentate ligand and binds to one metal centre only, in spite of the presence of three equivalent amino nitrogens. In the Co(II) and Ni(II) complexes, a two-dimensional intermolecular hydrogen bonding network between the aqua-and the chloro ligands is established. The uncoordinated amines of the 7-nitro-1,3,5-triaza-adamantane are not involved in any Hbonding, as a result of the exceptionally low basicity of this compound.

Synthesis, characterisation and in vitro cytotoxicity of mixed ligand Pt(ii) oxadiazoline complexes with hexamethylenetetramine and 7-nitro-1,3,5-triazaadamantane

“…In this work, hexamethylenetetamine (hmta, also known as 1,3,5,7-tetraazaadamantane) is explored for a similar purpose, and compared with 7-nitro-1,3,5-triazaadamantane. Hmta is known to coordinate to transition metals in various ways, 16 although only very few reports exist on platinum complexes. 17,18 Hmta is used, as hippurate and other salts, against urinary infections, and the mode of action is assumed to be based on the slow release of formaldehyde.…”