Monoolein Cubic Phase Gels and Cubosomes Doped with Magnetic Nanoparticles–Hybrid Materials for Controlled Drug Release

Szlezak, Monika; Nieciecka, Dorota; Joniec, Aleksandra; Pękała, M.; Górecka, Ewa; Emo, Mélanie; Stébé, M.J.; Krysiński, Paweł; Bilewicz, Renata

doi:10.1021/acsami.6b12889

Cited by 61 publications

(54 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More recently additional methods for controlled release have been proposed including magnetic nanoparticles [128] and pH sensitive polymers [129] incorporated into cubosomes.…”

Section: Release Mechanismsmentioning

confidence: 99%

“…The magnetic properties were retained when tested in a magnetic field of a neodymium magnet demonstrating that cubosome systems can be exploited for magnetic drug targeting, hyperthermia treatment, or magnetic resonance imaging. [128] Monoolein cubosomes (stabilized with F127) with 10 wt% of a poly(L-lysine-iso-phthalamide) grafted with L-phenylalanine have been reported. This polymer has a pH responsive hydrophilic/hydrophobic balance changing conformation in response to external pH (extended chains at neutral pH and globular at acidic pH).…”

Section: Release Mechanismsmentioning

confidence: 99%

See 1 more Smart Citation

Cubosomes: The Next Generation of Smart Lipid Nanoparticles?

2018

View full text Add to dashboard Cite

Cubosomes are highly stable nanoparticles formed from the lipid cubic phase and stabilized by a polymer based outer corona. Bicontinuous lipid cubic phases consist of a single lipid bilayer that forms a continuous periodic membrane lattice structure with pores formed by two interwoven water channels. Cubosome composition can be tuned to engineer pore sizes or include bioactive lipids, the polymer outer corona can be used for targeting and they are highly stable under physiological conditions. Compared to liposomes, the structure provides a significantly higher membrane surface area for loading of membrane proteins and small drug molecules. Owing to recent advances, they can be engineered in vitro in both bulk and nanoparticle formats with applications including drug delivery, membrane bioreactors, artificial cells, and biosensors. This review outlines recent advances in cubosome technology enabling their application and provides guidelines for the rational design of new systems for biomedical applications.

show abstract

“…More recently additional methods for controlled release have been proposed including magnetic nanoparticles [128] and pH sensitive polymers [129] incorporated into cubosomes.…”

Section: Release Mechanismsmentioning

confidence: 99%

Section: Release Mechanismsmentioning

confidence: 99%

Cubosomes: The Next Generation of Smart Lipid Nanoparticles?

2018

View full text Add to dashboard Cite

show abstract

“…Important examples include nucleic acid loading for gene delivery applications (9,13) and guiding of protein crystallization (14). Other applications, such as directed assembly of hard materials, have been recently proposed as well (15)(16)(17). Restrictions to the use of these lyotropic materials are small unit cells and concomitant narrow water channels (typical diameters, d w = 5 nm) (18).…”

mentioning

confidence: 99%

Super-swelled lyotropic single crystals

Kim

Song

Leal

2017

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Lipids self-assemble into diverse supramolecular structures that exhibit thermotropic and/or lyotropic behavior. Lyotropic mesophases, where membranes conform to periodic minimal surfaces dividing two nonpenetrating aqueous subspaces, are arguably one of the most intriguing phases of lipid materials. Traditional 3D bicontinuous cubic lipid materials appear as a polycrystal of varying degrees of order. When exposed to water, the properties of the molecular building blocks of the membrane determine specific swelling limits setting the lattice dimensions at about 15 nm. This limited swelling severely impairs their application as delivery vehicles of large drugs or as matrices for guiding protein crystallization. We report the discovery of self-assembly strategies leading to the emergence of lipid bicontinuous single crystals with unprecedented swelling capacity. The conventional strategy to increase unit cell size is tweaking membrane composition to include charged building blocks, a process to achieve electrostatic-driven swelling. In this paper, we demonstrate that controlling self-assembly external conditions when coupled to membrane composition yields 3D bicontinuous cubic phases that swell up to lattice dimensions of 68 nm. Importantly, and contrary to what is perceived for soft lyotropic materials in general, the self-assembly methodology enables the development of large super-swelled monocrystals. Utilizing small-angle X-ray scattering and cryoelectron microscopy, we underpin three crucial factors dictating the stabilization of super-swelled lipid bicontinuous cubic single crystals: () organic solvent drying speed, () membrane charge density, and () polyethylene glycol-conjugated lipids amount.

show abstract

“…This is interesting because it has been shown that the addition of metal‐based NPs to liquid crystalline particles usually alter their structure. Examples come from reports on cubosomes (dispersions of reverse bicontinuous lipid cubic phases) functionalized with iron oxide NPs and gold nanorods . In both cases, the addition of metal NPs promoted changes in the cell parameter of the initial liquid crystalline structure or favored the formation of additional structures.…”

Section: Resultsmentioning

confidence: 99%

Planet–Satellite Nanostructures Based on Block Copolymer‐Surfactant Nanoparticles Surface‐Decorated with Gold and Silver: A New Strategy for Interfacial Catalysis

Ferreira¹,

Loh²

2019

Adv Materials Inter

View full text Add to dashboard Cite

comprises the planet and the metal NPs, the satellites. [6,15,16] The fabrication of polymer-based planet-satellite nanostructures is particularly interesting because it was shown that the surface-exposed metal NPs can be easily accessed by species in the surrounding media, a step that is crucial for catalysis and sensing purposes. Such a strategy also allows the control of the interparticle distance of surfacelocated metal NPs which is well known to impact on their optical, electronic, and magnetic properties. [6] Using this approach, several nanoconjugate systems have been described in the recent years, aiming at different potential applications. Block copolymer micelles: [2][3][4][5][6] pH-and temperature-responsive microgels [7,8] and crosslinked polymer particles [9,10] are examples of polymeric nanomaterials assembled with Au and Ag NPs which have been used for catalytic, stimuli-responsive, and drug delivery purposes.The potential uses of the planet-satellite nanostructures in a variety of fields strongly depends on their colloidal stability, regarding both polymer and metal NPs, because in most of the cases, the nanoconjugates are finely tuned to display specific properties that must remain unchanged upon suitable variations in environment conditions, specially the pH and ionic strength. Hence, the fabrication of new polymer-based nanoconjugates with excellent colloidal stability is highly desired.Core-shell particles, collectively known as complex coacervate core micelles (C3Ms), made from charged−neutral block copolymers and oppositely charged surfactant ions have been widely reported in the last years and the most studied systems are comprised of alkyltrimethylammonium cationic surfactants and the block copolymer poly(acrylamide)-block-poly(acrylic acid) (PAAm-b-PAA). [17][18][19][20][21][22][23][24] The particles core contains several densely packed-surfactant micelles surrounded by the anionic block of the copolymer and the outer part consists in a corona composed by the neutral PAAm chains. By using the "complex salt" (CS) approach, [21][22][23] the production of dispersed particles with a variety of surfactant-rich liquid crystalline cores were shown to be achieved. In addition, these particles, refereed here as CS, were shown to display enhanced colloidal stability. [21][22][23] It was noted that the CS particles display different properties, such as size, surface charge, and core structure, if compared with those typically found for particles, referred Gold (Au) and silver (Ag) nanoparticles (NPs) are covalently conjugated onto the surface of thiol-functionalized block copolymer particles containing surfactant-rich liquid crystalline cores. The resulting planet-satellite nanoconjugates display enhanced colloidal stability upon changes in solution pH or ionic strength and interfacial properties that result in the stabilization of oil-in-water emulsions. These biphasic systems are used as medium for catalyzed aerobic oxidation of benzyl alcohol to benzoic acid and the nanoconjugates display catalyt...

show abstract

Monoolein Cubic Phase Gels and Cubosomes Doped with Magnetic Nanoparticles–Hybrid Materials for Controlled Drug Release

Cited by 61 publications

References 53 publications

Cubosomes: The Next Generation of Smart Lipid Nanoparticles?

Cubosomes: The Next Generation of Smart Lipid Nanoparticles?

Super-swelled lyotropic single crystals

Planet–Satellite Nanostructures Based on Block Copolymer‐Surfactant Nanoparticles Surface‐Decorated with Gold and Silver: A New Strategy for Interfacial Catalysis

Contact Info

Product

Resources

About