Monostotic Fibrous Dysplasia Involving the Mandible: A Case Report

Abstract

Fibrous dysplasia (FD) is a skeletal developmental anomaly, which is non-hereditary and idiopathic in origin. It is characterized by the replacement of normal bone with the excess proliferation of fibrous tissue in irregular bony trabeculae. Patients might complain of swelling, pain, or numbness on the affected side. The incidence of monostotic FD (MFD) is four times more than that of polyostotic fibrous dysplasia. In MFD, the maxilla is more commonly affected than the mandible. The clinical behavior and rapid progression of FD renders the treatment challenging. The malignant potential is 0.5% for untreated cases. Here, we present a case of FD involving the mandible. The clinical diagnostic approach, different imaging modalities, and histological examination methods for definitive diagnosis have been elaborated.

Fibrous Dysplasia: A Retrospective Review of Histologically Diagnosed Cases in a Tertiary Health Care Centre in Nigeria

“…Fibrous dysplasia accounts for between 0.8-2.5% of primary bone tumours and 5-7% of benign bone tumours, however the true incidence is difficult to determine because some affected individuals are asymptomatic [2,8,10,12,14]. Fibrous dysplasia accounted for 17% of primary bone tumours and 27% of benign bone tumours in our study which is significantly higher than the figures seen worldwide [4,5,7].…”

“…Fibrous dysplasia can occur in any bone, common sites of diagnosis are the craniofacial bones, proximal femur and ribs [5,11]. The most common site of fibrous dysplasia diagnosis is in craniofacial bones, with the maxilla being involved more frequently than other craniofacial bones [2,3,11,14]. A majority of fibrous dysplasia cases in our study, 23 (82.1%) out of a total of 28 occurred in craniofacial bones, which correlates with the findings of authors in Nigeria and other parts of the world [4,16,17].…”

Reconstrução de região infraorbitária após ressecção de displasia fibrosa com enxerto ósseo bovino liofilizado

“…A displasia fibrosa (DF) é uma anomalia do desenvolvimento esquelético caracterizada pela substituição do osso normal pelo excesso de proliferação de tecido fibroso em trabéculas ósseas irregulares (Assiri, 2020;Pereira et al, 2019).…”

“…Na região craniofacial, o complexo zigomático-maxilar e o mais afetado pela DF monostótica (Assiri, 2020;Bertin et al, 2020;Pontes-Madruga et al, 2020;Verma et al, 2013). Clinicamente, uma DF causa expansão óssea, sendo geralmente diagnosticada na infância, adolescência ou adulto até terceira década de vida.…”

“…Mutações somáticas pós-zigóticas são observadas no gene GNAS1 e associadas à displasia fibrosa (Ahn et al, 2018;Boyce & Collins, 2020;Pereira et al, 2019). A transformação maligna espontânea da DF é considerada um evento raro (Assiri, 2020;Lee et al, 2012;Sadeghi & Hosseini, 2011).…”