Monostrain, multistrain and multispecies probiotics—A comparison of functionality and efficacy

Timmerman, Harro M.; Koning, Catherina J. M.; Mulder, Linda; Rombouts, F.M.; Beynen, A.C.

doi:10.1016/j.ijfoodmicro.2004.05.012

Cited by 508 publications

(351 citation statements)

References 45 publications

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“…The use of a multistrain probiotic product has been recommended (Timmerman et al, 2004) and the bacterial formula is more efficient when ingested as fermented milk than as freeze-dried powder (Goldin et al, 1992;Saxelin, 1997).…”

Section: Discussionmentioning

confidence: 99%

Prevention of antibiotic-associated diarrhoea by a fermented probiotic milk drink

et al. 2007

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Objective: To study the preventive effect of a milk drink fermented with multistrain probiotics on antibiotic associated diarrhoea (AAD). Design: Double-blind placebo controlled study. Setting: University Hospital of North Norway. Subjects and methods: Of 853 patients treated with antibiotics, 87 met the inclusion criteria, and were randomized to ingestion of a fermented milk drink containing LGG, La-5 and Bb-12 (n ¼ 46) or placebo with heat-killed bacteria (n ¼ 41), during a period of 14 days. A diary was recorded, and stool samples were collected for microbiological analyses. Results: Sixty-three patients completed the study according to the protocol; two patients (5.9%) in the treatment group and eight (27.6%) in the placebo group developed AAD (P ¼ 0.035). The relative risk of developing AAD was 0.21 (95% confidence interval: 0.05-0.93) when given probiotic milk drink. Conclusion: A fermented multistrain probiotic milk drink may prevent four of five cases of AAD in adult hospitalized patients. Sponsorship: TINE BA, Oslo, Norway.

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Section: Discussionmentioning

confidence: 99%

Prevention of antibiotic-associated diarrhoea by a fermented probiotic milk drink

et al. 2007

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“…The discrepancy among different investigations may be due to the amount and types of probiotics administered (Pagnini et al 2010), as well as the combination and potential synergistic effect of different microorganisms. While some researchers encourage the design and use of several strains and/or species of microorganisms in probiotic formulations (Timmerman et al 2004), few data support a more beneficial effect of these multi-strains/species preparations compared to single strain preparations.…”

Section: Probiotics and Prebioticsmentioning

confidence: 99%

Gastrointestinal microorganisms in cats and dogs: a brief review

Garcia-Mazcorro¹,

Minamoto

2013

Arch. med. vet.

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RESUMENEl tracto gastrointestinal (GI) de animales contiene diferentes tipos de microorganismos conocido como la microbiota GI. Por mucho tiempo, la microbiota GI ha generado interés porque los microorganismos GI están involucrados en múltiples procesos fisiológicos en el hospedero, así perpetuando salud o enfermedad. Estudios recientes han demostrado que la microbiota GI de gatos y perros es tan compleja como en humanos y otros animales, revelado con el uso de tecnologías de secuencia modernas y otras técnicas moleculares. La microbiota GI incluye miembros de todos los tres dominios principales de vida (Archaea, Bacterias y Eucariotas), pero las bacterias son el grupo de microorganismos más abundante y metabólicamente activo. El estómago de gatos y perros esta principalmente poblado de Helicobacter spp., el cual en perros puede representar tanto como el 98% de toda la microbiota bacteriana en el estómago. El intestino delgado contiene una microbiota más diversa, conteniendo representantes de al menos cinco diferentes filos bacterianos (principalmente Firmicutes y Bacteroidetes). El intestino grueso contiene el grupo de bacterias más abundante (~10 11 células bacterianas por gramo de contenido intestinal), diverso (al menos diez diferentes filos han sido detectados) y metabólicamente relevante en el tracto GI. La mayoría de las bacterias en el intestino grueso son anaerobios estrictos, los cuales dependen de la fermentación de sustancias no digeridas para subsistir. Aunque estudios recientes han dilucidado las complejidades de la microbiota GI en gatos y perros, más investigación todavía es necesaria para encontrar maneras de manipular exitosamente los microorganismos GI para prevenir y/o tratar enfermedades GI.Palabras clave: gastrointestinal, microbiota, gatos, perros. SUMMARYThe gastrointestinal (GI) tract of animals contains different types of microorganisms known as the GI microbiota. The GI microbiota has long been of interest because of its involvement in multiple physiological processes in the host, influencing health or disease. Recent studies have shown that the GI microbiota of cats and dogs is as complex as the one present in humans and other animals, according to state-of-the-art sequencing technologies and other molecular techniques. The GI microbiota includes members of all three main life domains (Archaea, Bacteria, and Eukaryotes), with bacteria being the most abundant and metabolically active group of microorganisms. The stomach of cats and dogs is mainly inhabited by Helicobacter spp., which in dogs may account for as much as 98% of all gastric bacterial microbiota. The small intestine harbors a more diverse microbiota as it contains representatives from at least five bacterial phyla (mainly Firmicutes and Bacteroidetes). The large intestine harbors the most abundant (~10 11 bacterial cells per gram of intestinal content), diverse (at least 10 bacterial phyla have been identified) and physiologically relevant group of bacteria in the GI tract. Most bacteria in the large intestine are strict an...

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“…Until recently, information on combination of mixed bacterial-based probiotic is lacking although its application into poultry production is on the increase. According to Gardiner et al (2004) and Timmerman et al (2004), functionality of a multi-strain/multi-species probiotics could be more effective and more consistent than that of a mono-strain.…”

Section: Introductionmentioning

confidence: 99%

Effects of supplementation of multi-enzyme and multi-species probiotic on production performance, egg quality, cholesterol level and immune system in laying hens

Khan¹,

Atif

Mukhtar

et al. 2011

Journal of Applied Animal Research

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A study was conducted to evaluate enzyme and probiotic feed supplements as alternative feed additives to alleviate the problems associated with the withdrawal of antibiotics from layer diet. A total of 180 Hy-Line W-98 hens, 40 weeks old, were assigned into four treatment groups so that there were 45 laying hens in each group. Four dietary treatments were randomly assigned to the four groups of hens. Hens in Group 1 were fed basal diet only (negative control), Group 2 was fed basal diet ' antibiotic at a level of 2.0 g/kg (positive control), Group 3 was fed basal diet ' multi-enzyme at a level of 2.0 g/kg (ES) and Group 4 was fed basal diet ' multi-species probiotic at a level of 0.5 g/kg (PS). The results showed that addition of either enzyme or probiotic supplementation to the basal diet significantly increased the egg production, egg weight and egg mass of hens than the negative control group. There was no significant difference in feed intake among treatments, although the feed conversion improved with the addition of antibiotic, enzyme and probiotic than the negative control. Over the 70-day trial period, weight gain was higher than the negative control for birds fed the diet containing probiotic. There was no significant effect on mortality during the study. Haugh unit score was significantly increased in the groups fed the ES and PS diets when compared with negative control group. Egg shape index, specific gravity, yolk index, shell weight, shell thickness and damaged eggs did not differ significantly among the laying hens of all dietary groups. High-density lipoprotein-cholesterol was significantly increased by probiotic supplementation compared with other dietary groups. Dietary treatments did not influence eosinophils and monocytes, increased lymphocyte and decreased heterophil and H:L ratio. The geometric means haemagglutination inhibition titres of birds fed on diets containing antibiotic, enzyme and probiotic supplementation were higher from 28 to 70 days than that of negative control. It may be concluded that the supplementation of enzyme and probiotic in layer diets did not appear to cause any adverse effects on egg production, egg quality and immunity compared with the negative control laying hens and non-antibiotic feed additives can be used as alternative. Moreover, the dietary supplementation of probiotic may lead to the development of low-cholesterol chicken eggs as demanded by health-conscious consumers.

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Monostrain, multistrain and multispecies probiotics—A comparison of functionality and efficacy

Cited by 508 publications

References 45 publications

Prevention of antibiotic-associated diarrhoea by a fermented probiotic milk drink

Prevention of antibiotic-associated diarrhoea by a fermented probiotic milk drink

Gastrointestinal microorganisms in cats and dogs: a brief review

Effects of supplementation of multi-enzyme and multi-species probiotic on production performance, egg quality, cholesterol level and immune system in laying hens

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