2020
DOI: 10.1016/j.ejmech.2020.112726
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Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process

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Cited by 29 publications
(24 citation statements)
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“…Target borneol derivatives were synthesised via a sequence of reactions starting with commercially available (-)-borneol. Borneol derivatives 8a-c and 9a-c with a tertiary amino group were prepared in two steps as described previously [ 19 ]. Subsequent methylation, using iodomethane under reflux, gave the corresponding quaternary ammonium salts 10a, 10c and 11a-b (Scheme 2 ).…”
Section: Resultsmentioning
confidence: 99%
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“…Target borneol derivatives were synthesised via a sequence of reactions starting with commercially available (-)-borneol. Borneol derivatives 8a-c and 9a-c with a tertiary amino group were prepared in two steps as described previously [ 19 ]. Subsequent methylation, using iodomethane under reflux, gave the corresponding quaternary ammonium salts 10a, 10c and 11a-b (Scheme 2 ).…”
Section: Resultsmentioning
confidence: 99%
“…All of the target compounds reported in this publication were of at least 98% purity. The synthesis of derivatives 1 and 2 [ 11 ] and 8a-c and 9a-c [ 19 ] were described previously. Compounds 6-7, 10a and c, and 11a and b, have not been described previously in the literature.…”
Section: Methodsmentioning
confidence: 99%
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“…Target borneol derivatives were synthesized via a sequence of reactions starting with a commercially available (-)-borneol. Borneol derivatives 8a-c and 9a-c with tertiary amino group were prepared in two steps as previously described [18]. Subsequent methylation, using iodomethane under re ux, gave corresponding quaternary ammonium salts 10a, 10c and 11a-b (Scheme 2).…”
Section: Chemistrymentioning
confidence: 99%
“…We discovered several borneol ester molecules with activity against Ebola virus (EBOV) and Marburg virus (MARV) and in uenza virus, for example, compounds 4-5 [ 15,16,17 ]. Moreover, we have shown that the possible mechanism of inhibition of EBOV is binding to the active site of EBOV glycoprotein [ 18 ]. The lovirus family, which includes EBOV and MARV, and the orthomyxovirus family, which includes the in uenza virus, belong to class I fusion proteins and have similar pre-and post-fusion forms [ 19 ].…”
Section: Introductionmentioning
confidence: 98%