Monoterpenoid indole alkaloid dimers from the Melodinus axillaris induce G2/M phase arrest and apoptosis via p38 MAPK activation in HCT116 cells

Du, Kaicheng; Li, Xingyao; Zheng, Changwei; Lai, Lantao; Shen, Mingyi; Wang, Yumeng; Meng, Dali

doi:10.1016/j.bioorg.2023.106841

Bioorganic Chemistry

2023

DOI: 10.1016/j.bioorg.2023.106841

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Monoterpenoid indole alkaloid dimers from the Melodinus axillaris induce G2/M phase arrest and apoptosis via p38 MAPK activation in HCT116 cells

Kaicheng Du,

Xingyao Li,

Changwei Zheng

et al.

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Cited by 7 publications

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Monoterpene indole alkaloids with anticancer activity from Tabernaemontana species

Gonçalves,

Duarte,

Ramalhete

et al. 2024

Phytochem Rev

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Indole alkaloids, predominantly found in plants, are a large group of natural product-derived compounds characterized by a remarkable chemical diversity associated with significant biological properties. Among these, terpenoid indole alkaloids are the largest group of secondary metabolites. Tabernaemontana species (Apocynaceae) are widely distributed in tropical and subtropical regions of the world and used in traditional medicine to treat a variety of illnesses, including tumours. These species biosynthesize large quantities of structurally complex monoterpene indole and bisindole alkaloids. Given the compelling biological properties of indole alkaloids, the phytochemical study of Tabernaemontana species has been widely addressed to identify potential anticancer compounds. Several indole alkaloids have shown antiproliferative effect due to different mechanisms, namely by inducing apoptosis or arresting cell cycle, in diverse cancer cell lines, including multidrug-resistant phenotypes. This review primarily aims to underscore the anticancer activity of indole and bisindole alkaloids isolated from several Tabernaemontana species. Moreover, our recent contributions to the field are also highlighted, focusing on the study of Tabernaemontana elegans. The anticancer evaluation, namely the reversion of P-glycoprotein-mediated multidrug resistance, of two sets of monoterpene indole alkaloid derivatives, obtained by modification of some functional groups of two major monoterpene indole alkaloids, is reviewed, as well as the results obtained for a derivative that targeted homologous recombination DNA repair defects.

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Monoterpene indole alkaloids with anticancer activity from Tabernaemontana species

Gonçalves,

Duarte,

Ramalhete

et al. 2024

Phytochem Rev

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show abstract

Exploring plant-derived bisindole alkaloids: a comprehensive review of sources, phytochemistry and cytotoxicity

Zhang,

Li,

et al. 2024

Phytochem Rev

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Monoterpenoid indole alkaloids from Melodinus axillaris W.T.Wang exhibit anti-inflammatory activities by inhibiting the NF-κB signaling pathways

Du,

Liang,

Song

et al. 2024

Journal of Ethnopharmacology

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Monoterpenoid indole alkaloid dimers from the Melodinus axillaris induce G2/M phase arrest and apoptosis via p38 MAPK activation in HCT116 cells

Cited by 7 publications

References 43 publications

Monoterpene indole alkaloids with anticancer activity from Tabernaemontana species

Monoterpene indole alkaloids with anticancer activity from Tabernaemontana species

Exploring plant-derived bisindole alkaloids: a comprehensive review of sources, phytochemistry and cytotoxicity

Monoterpenoid indole alkaloids from Melodinus axillaris W.T.Wang exhibit anti-inflammatory activities by inhibiting the NF-κB signaling pathways

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