Monoterpenoids from the root bark of Acanthopanax gracilistylus and their inhibitory effects on neutrophil elastase, 5-lipoxygenase, andcyclooxygenase-2 in vitro

Yang, Hao-Dong; Tang, Zhi-Shu; Xue, Tao-Tao; Xu, Huai-Li; Hou, Bao-Long; Zhu, Ya-Ya; Su, Zeng-Hu; Xu, Hong-Bo

doi:10.1016/j.phytochem.2023.113851

Phytochemistry

2023

DOI: 10.1016/j.phytochem.2023.113851

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Monoterpenoids from the root bark of Acanthopanax gracilistylus and their inhibitory effects on neutrophil elastase, 5-lipoxygenase, andcyclooxygenase-2 in vitro

Hao-Dong Yang,

Zhi-Shu Tang,

Tao-Tao Xue

et al.

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2024

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Cited by 4 publications

References 30 publications

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Diterpenoids from Acanthopanacis Cortex and their anti-inflammatory activity studies

Yang,

Hou,

Yang

et al. 2024

Fitoterapia

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Diterpenoids from Acanthopanacis Cortex and their anti-inflammatory activity studies

Yang,

Hou,

Yang

et al. 2024

Fitoterapia

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Identification of lignans as selective cyclooxygenase-2 inhibitors from the extract of Acanthopanacis cortex

Yang,

Tang

et al. 2024

Phytochemistry

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Translational Perspectives on the Therapeutic Potential of Hyptis Crenata Essential Oil Terpenes in Smooth Muscle Function

Cardeal dos Santos,

da Cruz Freire,

Rodrigues

et al. 2024

Planta Med

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Monoterpenes and sesquiterpenes are classes of organic compounds found in various natural products, such as the essential oil of Hyptis crenata (EOHc). The therapeutic potential of these terpenes present in EOHc is evidenced by their effect on smooth muscle and potential clinical applications. Among the highlighted monoterpenes, such as sabinene, α-pinene, and β-pinene, a relaxing effect on rat intestinal smooth muscles is observed, attributed to interaction with calcium channels. Furthermore, monoterpenoids like borneol, cineole, and linalool also demonstrate vasorelaxant properties, suggesting potential in the treatment of cardiovascular conditions. Sesquiterpenes, such as caryophyllene and aromadendrenes, exhibit relaxing effects in various smooth muscle tissues, such as rat uterus and guinea pig ileum, indicating pharmacological potential in these areas. The translational exploration of targets, such as calcium channels and G protein-coupled receptors, highlights the importance of these compounds in discovering new therapies based on natural products for treating various medical conditions.

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Monoterpenoids from the root bark of Acanthopanax gracilistylus and their inhibitory effects on neutrophil elastase, 5-lipoxygenase, andcyclooxygenase-2 in vitro

Cited by 4 publications

References 30 publications

Diterpenoids from Acanthopanacis Cortex and their anti-inflammatory activity studies

Diterpenoids from Acanthopanacis Cortex and their anti-inflammatory activity studies

Identification of lignans as selective cyclooxygenase-2 inhibitors from the extract of Acanthopanacis cortex

Translational Perspectives on the Therapeutic Potential of Hyptis Crenata Essential Oil Terpenes in Smooth Muscle Function

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