Monotypic epithelioid angiomyolipoma of the kidney: A case report

Morioka, Motohiro; Kinugawa, Keigo; Funabiki, Sadami; Matsuda, Toshihiko; Furukawa, Yoji; Wani, Yoji

doi:10.1111/j.1442-2042.2006.01520.x

Cited by 6 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lipomatous components were also lacking in the several cases described as epithelioid AML, which were designated as ‘monotypic epithelioid AML’ 9–15 . Such tumors arose in the kidney or extrarenal sites, and had a very weak association with TS.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sclerosing variant of epithelioid angiomyolipoma

Matsuyama

Hisaoka

Ichikawa

et al. 2008

Pathology International

View full text Add to dashboard Cite

Presented herein are two unusual epithelioid angiomyolipomas (AML) displaying prominent stromal sclerosis. Both patients were middle-aged women without a clinical history of tuberous sclerosis. One patient (case 1) had a 2 cm lesion arising in the renal cortex, and another (case 2) had a pararenal retroperitoneal tumor measuring 13 cm. Both tumors were composed of sheets or nests of polygonal epithelioid or short spindle cells having uniform round to oval nuclei and eosinophilic cytoplasm with cords of hyalinized sclerotic stroma between them. The tumor in case 2 had small areas of mature-looking fat cells. Immunohistochemically, epithelioid tumor cells were diffusely positive for actins and desmin in both cases, and melanoma antigen recognized by T cells (MART)-1 was positive in patient 2. Scattered HMB-45-immunoreactive cells were identified in the sclerotic cords of both tumors, but epithelioid tumor cells were essentially negative for HMB-45. The characteristic clinicopathological and immunohistochemical features of the present cases are analogous to a subset of epithelioid AML or sclerosing perivascular epithelioid cell tumors previously reported.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Although one‐third of AML 16 and more than half of the epithelioid variant 17 are associated with TS, the association is less frequent in monotypic epithelioid AML 9–15 . Other PEComas are also only rarely TS associated 7,18–20 .…”

Section: Discussionmentioning

confidence: 99%

Sclerosing variant of epithelioid angiomyolipoma

Matsuyama

Hisaoka

Ichikawa

et al. 2008

Pathology International

View full text Add to dashboard Cite

show abstract

“…Epithelioid angiomyolipoma (EAML) of the kidney is a relatively newly described renal neoplasm that is closely related to the more common classic angiomyolipoma (AML) of the kidney and perivascular epithelioid cell neoplasm of extrarenal sites 1–4 . EAML is characterized by sheets of epithelioid cells displaying varying degrees of nuclear atypia often mimicking renal epithelial neoplasms 5–45 . In contrast to the classic AML, EAML may be associated with an adverse clinical course.…”

Section: Introductionmentioning

confidence: 99%

Renal epithelioid angiomyolipoma: a study of six cases and a meta‐analytic study. Development of criteria for screening the entity with prognostic significance

Faraji¹,

Nguyen

Kien

2009

Histopathology

View full text Add to dashboard Cite

show abstract

Renal Angiomyolipoma

Aydın¹,

Magi‐Galluzzi²,

Lane³

et al. 2009

American Journal of Surgical Pathology

211

View full text Add to dashboard Cite

The majority of renal angiomyolipoma (AML) is sporadic and occasionally it occurs as part of tuberous sclerosis complex (TSC). Epithelioid AML (EAML), an uncommon variant, is considered potentially malignant based on anecdotal case reports. The prognostic significance of epithelioid component in an otherwise typical AML is uncertain. We studied 194 AMLs for the clinicopathologic features of epithelioid and TSC-associated AMLs. Epithelioid component was present in 15 cases (7.7%) with an average amount of 51% (range: 10% to 100%). Histologically, the epithelioid tumor cells were categorized into small, intermediate, and large cell type based on the cell size. Worrisome histologic features were seen in many EAMLs, including coagulative tumor necrosis in 27% (4/15), nuclear atypia in 93% (14/15), mitosis in 47% (7/15), and atypical mitosis in 1 case. All 15 EAML patients had a mean follow-up time of 5.1 years and none had local recurrence or distant metastasis. Sixteen (8.2%) AMLs occurred in patients with definitive TSC. Three histologic features, namely microscopic AML foci, epithelioid component, and epithelial cysts, were present in 10 (62.5%), 4 (25%), and 44% (7/16), respectively, of TSC-associated AMLs, compared with 11 (6.2%), 11 (6.2%), and 6 (3.4%), respectively, in non-TSC-associated AMLs (P value all <0.01). In summary, all 15 cases of EAMLs in our study had benign clinical outcomes despite adverse pathologic features. Epithelioid component, epithelial cysts, and microscopic AML foci are strongly associated with TSC and the presence of all 3 features should raise strong suspicion for TSC.

show abstract

Monotypic epithelioid angiomyolipoma of the kidney: A case report

Cited by 6 publications

References 11 publications

Sclerosing variant of epithelioid angiomyolipoma

Sclerosing variant of epithelioid angiomyolipoma

Renal epithelioid angiomyolipoma: a study of six cases and a meta‐analytic study. Development of criteria for screening the entity with prognostic significance

Renal Angiomyolipoma

Contact Info

Product

Resources

About