Monounsaturated and polyunsaturated fatty acids: structure, food sources, biological functions, and their preventive role against noncommunicable diseases

Rincón‐Cervera, Miguel Ángel; Bravo-Sagua, Roberto; Freitas, Rosana Aparecida Manólio Soares; López-Arana, Sandra; Camargo, Adriano Costa de

doi:10.1016/b978-0-12-823569-0.00005-9

Cited by 5 publications

(3 citation statements)

References 163 publications

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“…The beneficial effects of hazelnuts on human health are related to the content of monounsaturated (MUFA) and polyunsaturated fatty acids (PUFAs), proteins, carbohydrates, dietary fibers, phytosterols (mainly b-sitosterol), vitamins (vitamin E), antioxidant phenolics, and minerals. MUFA and PUFA are responsible for health benefits including the lowering of plasma oxidized Low Density Lipoprotein (LDL) levels (Sun et al, 2022) and the prevention of cardiovascular diseases, diabetes, cancer, Alzheimer's disease, and dementia (Rincoń-Cervera et al, 2022), while tocopherols of hazelnuts are reported to exert positive effects in preventing heart disease and various types of cancer by inhibiting tumor growth and enhancing the human immune system (Dietrich et al, 2006;Bacchetta et al, 2013). Hazelnuts also contain several phytosterols; they constitute their cell membranes, stabilizing the phospholipid bilayer.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds, Functional Ingredients, Antioxidants, and Health Benefits of Edible Plants

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Introductionmentioning

confidence: 99%

Bioactive Compounds, Functional Ingredients, Antioxidants, and Health Benefits of Edible Plants

2024

Frontiers Research Topics

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“…The beneficial effects of hazelnuts on human health are related to the content of monounsaturated (MUFA) and polyunsaturated fatty acids (PUFAs), proteins, carbohydrates, dietary fibers, phytosterols (mainly β-sitosterol), vitamins (vitamin E), antioxidant phenolics, and minerals. MUFA and PUFA are responsible for health benefits including the lowering of plasma oxidized Low Density Lipoprotein (LDL) levels ( Sun et al., 2022 ) and the prevention of cardiovascular diseases, diabetes, cancer, Alzheimer’s disease, and dementia ( Rincón-Cervera et al., 2022 ), while tocopherols of hazelnuts are reported to exert positive effects in preventing heart disease and various types of cancer by inhibiting tumor growth and enhancing the human immune system ( Dietrich et al., 2006 ; Bacchetta et al., 2013 ). Hazelnuts also contain several phytosterols; they constitute their cell membranes, stabilizing the phospholipid bilayer.…”

Section: Introductionmentioning

confidence: 99%

Corylus avellana “Nocciola Piemonte”: metabolomics focused on polar lipids and phenolic compounds in fresh and roasted hazelnuts

Cerulli,

Napolitano,

Olas

et al. 2023

Front. Plant Sci.

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The common hazel plant (Corylus avellana L., Betulaceae) is one of the most popular tree nuts widespread in Europe and Asia. In Italy, there are different cultivars among which the cultivar affording the valuable hazelnut “Tonda Gentile Trilobata,” also known as “Tonda Gentile delle Langhe,” covered by the Protected Geographical Indication (PGI) label “Nocciola Piemonte” (NP), known for its sweetness, cooked-bread aroma, and the low intensity of the burnt aroma. In order to obtain a detailed and in-depth characterization of the polar fraction of fresh (NPF) and roasted (NPR) kernels of NP the analysis of the n-butanol extracts by liquid chromatography coupled to electrospray ionization and high-resolution mass spectrometry (LC-ESI/HRMS) was carried out. Moreover, to evaluate the quantitative distribution of the most representative polar lipids in NPF and NPR, the analysis by liquid chromatography combined with tandem mass spectrometry (LC-MS/MS) was performed. To unambiguously identify the phenolic compounds highlighted by the LC-ESI/HRMS profiles, they were isolated from the n-butanol extract and characterized by Nuclear Magnetic Resonance (NMR) experiments. Finally, the ability of the isolated compounds to exert radical scavenging activity and to inhibit the lipid peroxidation induced by H2O2 or H2O2/Fe2+ was tested by Trolox Equivalent Antioxidant Capacity (TEAC) and thiobarbituric acid reactive substances (TBARS) assays, respectively. The LC-ESI/HRMS allowed to ascertain the presence of phenolic compounds and multiple classes of polar lipids including phospholipids, glycolipids, sphingolipids, and oxylipins. The quantitative analysis highlighted in NPR fraction a lipid content three times higher than in NPF, evidencing lyso-phospholipids and phospholipids as the most represented lipid classes in both NPF and NPR, together accounting for 94 and 97% of the considered lipids, respectively. Furthermore, phytochemical analysis permitted to identify flavonoid and diarylheptanoid derivatives. In particular, quercetin 3-O-β-D-galactopyranosyl-(1→2)-β-D-glucopyranoside and myricetin-3-O-α-L-rhamnopyranoside showed the highest antioxidant activity, exhibiting TEAC values similar to that of quercetin, used as reference compound (2.00 ± 0.03 and 2.06 ± 0.03 mM vs 2.03 ± 0.03 mM, respectively). Moreover, most of the tested compounds were found to reduce lipid peroxidation induced by H2O2 and H2O2/Fe2+ more than curcumin used as positive control, with myricetin-3-O-α-L-rhamnopyranoside determining 44.4 % and 34.1 % inhibition percentage, respectively.

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“…Poly unsaturated fatty acids (PUFAs) and monounsaturated fatty acids (MUFAs) are essential bioactive compounds with multiple health benefits (Rincón-Cervera et al, 2022). PUFAs, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have tremendous applications in a variety of inflammatory conditions, such as arthritis, Alzheimer's disease, and lupus (Yates et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Bioprospecting Indigenous Marine Microalgae for Polyunsaturated Fatty Acids Under Different Media Conditions

Jain

Minhas

Shukla

et al. 2022

Front. Bioeng. Biotechnol.

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Marine microalgae produce a number of valuable compounds that have significant roles in the pharmaceutical, biomedical, nutraceutical, and food industries. Although there are numerous microalgal germplasms available in the marine ecosystem, only a small number of strains have been recognized for their commercial potential. In this study, several indigenous microalgal strains were isolated from the coast of the Arabian Sea for exploring the presence and production of high-value compounds such as polyunsaturated fatty acids (PUFAs). PUFAs are essential fatty acids with multiple health benefits. Based on their high PUFA content, two isolated strains were identified by ITS sequencing and selected for further studies to enhance PUFAs. From molecular analysis, it was found both the strains were green microalgae: one of them was a Chlorella sp., while the other was a Planophila sp. The two isolated strains, together with a control strain known for yielding high levels of PUFAs, Nannochloropsis oculata, were grown in three different nutrient media for PUFA augmentation. The relative content of α-linolenic acid (ALA) as a percentage of total fatty acids reached a maximum of 50, 36, and 50%, respectively, in Chlorella sp., Planophila sp., and N. oculata. To the best of our knowledge, this is the first study in exploring fatty acids in Planophila sp. The obtained results showed a higher PUFA content, particularly α-linolenic acid at low nutrients in media.

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Monounsaturated and polyunsaturated fatty acids: structure, food sources, biological functions, and their preventive role against noncommunicable diseases

Cited by 5 publications

References 163 publications

Bioactive Compounds, Functional Ingredients, Antioxidants, and Health Benefits of Edible Plants

Bioactive Compounds, Functional Ingredients, Antioxidants, and Health Benefits of Edible Plants

Corylus avellana “Nocciola Piemonte”: metabolomics focused on polar lipids and phenolic compounds in fresh and roasted hazelnuts

Bioprospecting Indigenous Marine Microalgae for Polyunsaturated Fatty Acids Under Different Media Conditions

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