Monozygotic co-twin analyses of body composition measurements and serum lipids

Zhang, Yuanyuan; Necheles, Jonathan; Ouyang, Fengxiu; Ma, Wei; Li, Zhiping; Li, Xue; Jiao, Yang; Huang, Xing; Xu, Xiping; Wang, Xiaobin

doi:10.1016/j.ypmed.2007.07.014

Cited by 26 publications

(37 citation statements)

References 35 publications

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“…These areas in China were predominantly rural (Ͼ90%) (14). Inclusion criteria of twins in the baseline survey were as follows: a) age, 6 -60 y; b) both twins were available for the survey; and c) both twins (or parents/ guardians of children) agreed and consented to participate in the survey.…”

Section: Methodsmentioning

confidence: 99%

“…However, little is known about the genetic and environmental influences on serum lipid levels and the tracking from childhood to adolescence in Chinese, which constitutes one-fifth of the world population. Over the past decade, China has experienced rapid economic, nutritional, and lifestyle changes, which have been accompanied by rapidly rising rates of dyslipidemia and associated diseases such as obesity, atherosclerosis, type 2 diabetes, and the metabolic syndrome (14). Compared with western populations, the rural Chinese population provides a unique opportunity to gain insight into the interplay of genetic and environmental factors on serum lipid profiles and tracking patterns.…”

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confidence: 99%

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Genetic and Environmental Influences on Serum Lipid Tracking: A Population-Based, Longitudinal Chinese Twin Study

et al. 2010

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ABSTRACT:We conducted cross-sectional and longitudinal twin analysis to explore genetic and environmental contribution to serum lipid tracking during childhood and adolescence. The study sample was part of a population-based twin cohort that was recruited in the rural areas of the Anhui Province of China. The baseline recruitment of twins was carried out from 1998 through 2000 and the follow-up from 2005 through 2007. Serum lipids showed significant tracking during childhood and adolescence. Participants with lipids at the highest tertile at the baseline tended to remain high at follow-up across ages and Tanner stages, whereas subjects with lipids at the lowest tertile at the baseline tended to remain low at follow-up. Using twin modeling, we showed that genetic and environmental factors contributed to individual variations in lipid levels and tracking from the baseline to the follow-up visit. The estimated tracking correlations for total cholesterol, triglyceride, and LDL cholesterol were in the range of 0.25-0.53 and were predominantly influenced by genetic factors. In contrast, the phenotypic tracking of HDL cholesterol was influenced by both genetic and environmental factors. Our study underscores the importance of considering both environmental and genetic factors in studying the etiology of dyslipidemia. (Pediatr Res 68: 316-322, 2010)

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

Genetic and Environmental Influences on Serum Lipid Tracking: A Population-Based, Longitudinal Chinese Twin Study

et al. 2010

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“…22 Briefly, the study populations were part of a community-based prospective twin cohort recruited from 1998 to 2000 in the rural area of Anqing, China (the baseline study). Since 2005, twins who participated in the baseline study have been followed to identify precursors of the metabolic syndrome.…”

Section: Study Populationmentioning

confidence: 99%

“…22 A waist circumference measurement was taken at the level of the umbilicus to the nearest centimeter. The final anthropometric values used in the analysis were the mean of three measurements.…”

Section: Anthropometric and Body Fat Measurementsmentioning

confidence: 99%

“…Twin zygosity (dizygotic or monozygotic) was determined using 10 autosomal polymorphic microsatellite markers as described in an earlier publication. 22 Plasma glucose was measured within 2 h of the sample collection by the modified hexokinase enzymatic method (Hitachi 7020 Automatic Analyzer, Hitachi, Tokyo, Japan). Plasma insulin was measured by the electrochemiluminescence method on an Elecsys 2010 system (Roche, Basel, Switzerland).…”

Section: Laboratory Measurementmentioning

confidence: 99%

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Association of adipokines with blood pressure in rural Chinese adolescents

et al. 2011

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Previous research has demonstrated that adipokines influence blood pressure (BP). Limited data exist in healthy adolescents, who are in a critical period for preventing the development of high BP. This study investigated the association of leptin, adiponectin and the leptin-to-adiponectin ratio (LAR) with BP in rural Chinese adolescents. This report included 1245 adolescents (average body mass index: 19.3 kg m À2 ) aged 13-21 years from an established twin cohort. We examined gender-specific associations between plasma adipokines and BP, with adjustment for measures of adiposity and insulin resistance (IR). We estimated the genetic contribution to adipokines using the twin design and Cholesky decomposition models. There was no correlation between leptin and adiponectin levels. Leptin was positively associated with systolic blood pressure (SBP) in males and diastolic blood pressure in females, but the association disappeared after adjusting for adiposity and IR. LAR was positively associated with SBP (b(s.e.): 1.94(0.45)), Po0.01), adiponectin was negatively associated with SBP (b(s.e.): À2.18(0.63)), Po0.001) only in males, and such associations were independent of adiposity and IR. A test of gender Â adiponectin interaction was significant (P ¼ 0.01). Heritability estimation showed that both environmental and genetic factors contribute to variance in adipokines. In these relatively lean Chinese adolescents, leptin was positively associated with BP in both genders, but was adiposity/IR dependent. Adiponectin was negatively associated with SBP in males, independent of adiposity/IR.

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Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese adolescents

Hong

Arguelles

Liu

et al. 2010

Journal of Bone and Mineral Research

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This study was an attempt to examine the phenotypic, genetic, and environmental correlations between percent fat mass (PFM) and bone parameters, especially hip geometry, among 786 males and 618 females aged 13 to 21 years from a Chinese twin cohort. PFM, bone area (BA), bone mineral content (BMC), cross-sectional area (CSA), and section modulus (SM) were obtained by dual-energy X-ray absorptiometry. Multiple linear regression models were used to assess the PFM-bone relationships. A structural equation model for twin design was used to estimate genetic/environmental influences on individual phenotype and phenotypic correlations. After controlling for body weight and other pertinent covariates, we observed inverse associations between PFM and bone parameters: Compared with the lowest age- and gender-specific tertile of PFM, males in the highest tertile of PFM had lower measures of whole-body-less-head BA (WB-BA), lumbar spine BA (L2–L4-BA), total-hip BA (TH-BA), total-hip BMC, CSA, and SM (p < .005 for all, adjusted p < .05). Similar inverse associations were observed in females for all the preceding parameters except WB-BA and L2–L4-BA. These associations did not vary significantly by Tanner stages. In both genders, the estimated heritabilities were 80% to 86% for BMC, 67% to 80% for BA, 74% to 77% for CSA, and 64% for SM. Both shared genetics and environmental factors contributed to the inverse PFM-bone correlations. We conclude that in this sample of relatively lean Chinese adolescents, at a given body weight, PFM is inversely associated with BA, BMC, and hip geometry in both genders, and such associations are attributed to both shared genetic and environmental factors. © 2010 American Society for Bone and Mineral Research.

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Monozygotic co-twin analyses of body composition measurements and serum lipids

Cited by 26 publications

References 35 publications

Genetic and Environmental Influences on Serum Lipid Tracking: A Population-Based, Longitudinal Chinese Twin Study

Genetic and Environmental Influences on Serum Lipid Tracking: A Population-Based, Longitudinal Chinese Twin Study

Association of adipokines with blood pressure in rural Chinese adolescents

Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese adolescents

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