Monte Carlo Calculations of Energy Deposition in DNA for Auger Emitters

Ftá_niková, S.; Böhm, R.

doi:10.1093/oxfordjournals.rpd.a033292

Cited by 23 publications

(12 citation statements)

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“…Monte Carlo track-structure codes simulating collision-bycollision the slowing down process of all generations of particles are known to be best suited for such applications since they methodologically account for all the above deficiencies of the CSDA (Nikjoo et al 2006). The (micro) dosimetry of low-energy Auger electrons at the sub-cellular (and DNA) level have been studied by several track-structure codes (Charlton 1986, Wright et al 1990, Pomplun 1991, Bolch and Kim 1994, Nikjoo et al 1996, Ftacnikova and Bohm 2000a, Torres-Garcia et al 2006.…”

Section: Methodsmentioning

confidence: 99%

Subcellular S-factors for low-energy electrons: A comparison of Monte Carlo simulations and continuous-slowing-down calculations

Emfietzoglou

Kostarelos

Hadjidoukas

et al. 2008

International Journal of Radiation Biology

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Section: Methodsmentioning

confidence: 99%

Subcellular S-factors for low-energy electrons: A comparison of Monte Carlo simulations and continuous-slowing-down calculations

Emfietzoglou

Kostarelos

Hadjidoukas

et al. 2008

International Journal of Radiation Biology

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“…The best models, based on Monte-Carlo simulations, can only give S-values on the base of a single cell, or a symmetrically organised monolayer [42,246]. The early methods used by Charlton and Humm still provide a good estimate of the number of dsbs in single cells [247], but MC methods for Auger microdosimetry [23,45,[248][249][250][251] incorporate all data from Auger, CE and CK electron emissions from radionuclides. Nevertheless, it has proven difficult to take the non-uniformity of intracellular and intranuclear distribution, and the structure of the chromatin itself into account, and the models still only provide dosimetry on a single-cell basis, which can give but an approximation for solid tumours [18,42,246].…”

Section: Challengesmentioning

confidence: 99%

Targeting the Nucleus: An Overview of Auger-Electron Radionuclide Therapy

Cornelissen¹,

Vallis

2010

CDDT

108

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The review presented here lays out the present state of the art in the field of radionuclide therapies specifically targeted against the nucleus of cancer cells, focussing on the use of Auger-electron-emitters. Nuclear localisation of radionuclides increases DNA damage and cell kill, and, in the case of Auger-electron therapy, is deemed necessary for therapeutic effect. Several strategies will be discussed to direct radionuclides to the nucleoplasm, even to specific protein targets within the nucleus. An overview is given of the applications of Auger-electron-emitting radionuclide therapy targeting the nucleus. Finally, a few suggestions are made as how radioimmunotherapy with nuclear targets can be improved, and the challenges that might be met, such as how to perform accurate dosimetry measurements, are examined.

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“…This reveals the significance of dosimetry calculation and the study of the effects of the Auger electron-emitting diagnostic radioisotopes. Table 5 shows the results of studies previously carried out by Raisali et al .,[ 20 ] Pomplun[ 7 ] and Ftacnikova and Bohm[ 15 ] who calculated the SSBs and DSBs caused by the Auger electrons for 123 I and 125 I radioisotopes.…”

Section: R Esults and Discussionmentioning

confidence: 99%

“…Two other volumes included semi-cylindrical shells of height of 0.34 nm, internal radius of 0.5 nm, and external radius of 1.5 nm, which surrounds the central cylinder and represents the volume occupied by sugar-phosphate backbone. Ftacnikova and Bohm[ 15 ] and Humm and Charlton[ 16 ] used this model to count the DNA molecule breaks. In their study, Ftacnikova and Bohm[ 15 ] calculated the number of SSBs caused by direct effects of the Auger electrons per decay using the ETRACK code for the 123 I, 125 I, 67 Ga, 99 m Tc, and 77 Br radioisotopes as 0.72, 1.18, 0.39, 0.57 and 0.46, respectively and the number of DSB for 125 I as 0.73.…”

Section: Introductionmentioning

confidence: 99%

Assessment of single- and double-strand breaks in DNA induced by auger electrons of radioisotopes used in diagnostic and therapeutic applications

Moradi

Bidabadi

2020

J Med Phys

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Introduction: Most of the radionuclides that are used for diagnostic purposes emit Auger electrons and can thus cause damage to the DNA molecule on a nanometer scale. Therefore, the nanodosimetric calculation of these radioisotopes is necessary to achieve better understanding on their effects. Aim: The aim of this study was to calculate the mean number of DNA strand breaks (single-strand breaks and double-strand breaks) caused by direct and indirect effects for six widely used Auger electron-emitting diagnostic radioisotopes, including 123 I, 125 I, 99m Tc, 67 Ga, 201 Tl, 111 In and two therapeutic radioisotopes of 131 I(beta + Auger + CK emitter) and 211 At(alpha + Auger + CK emitter). Materials and Methods: Geant4-DNA simulation tool was used to evaluate the effects of Auger electrons, beta and alpha particles of these radioisotopes on DNA molecules. Two different DNA molecule geometric models were simulated and the results of these two models were compared with each other as well as with the results of previous studies. Results and Conclusion: The results showed that the geometric shape of the sugar-phosphate groups may have a significant effect on the number of single-strand breaks (SSBs) and double-strand breaks (DSBs) of the DNA molecule. Among the most widely used diagnostic radioisotopes, 201 Tl and 125 I, had the greatest impact on the number of SSBs and DSBs, respectively, while therapeutic radioisotope of 131 I almost had no effect, therapeutic radioisotope of 211 At had the moderate effect on the number of breaks in the DNA chain.

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Monte Carlo Calculations of Energy Deposition in DNA for Auger Emitters

Cited by 23 publications

References 0 publications

Subcellular S-factors for low-energy electrons: A comparison of Monte Carlo simulations and continuous-slowing-down calculations

Subcellular S-factors for low-energy electrons: A comparison of Monte Carlo simulations and continuous-slowing-down calculations

Targeting the Nucleus: An Overview of Auger-Electron Radionuclide Therapy

Assessment of single- and double-strand breaks in DNA induced by auger electrons of radioisotopes used in diagnostic and therapeutic applications

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