Monte Carlo simulations support non-Cerenkov radioluminescence production in tissue

Ackerman, Nicole; Boschi, Federico; Spinelli, Antonello E.

doi:10.1117/1.jbo.22.8.086002

Cited by 4 publications

(3 citation statements)

References 52 publications

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“…Another possible source that has been investigated is radioluminescence light that is normally produced by the interaction of ionizing radiations with a scintillator material. However it has been recently shown that radioluminescence light can also be produced in non scintillating material like: Plexiglas, glass [33] small animals [34] or ex vivo tissue [35]. An alternative solution to solve the problem of light tissue penetration is the use of an external X-rays source in combination with scintillating nanoparticles (ScNPs).…”

Section: Pdt Using Radioluminescence Lightmentioning

confidence: 99%

Photodynamic Therapy Using Cerenkov and Radioluminescence Light

Spinelli

Boschi

2021

Front. Phys.

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In this short review the potential use of Cerenkov radiation and radioluminescence as internal sources for Photodynamic therapy (PDT) is discussed. PDT has been developed over the course of more than 100 years and is based on the induced photo conversion of a drug called photosensitizer (PS) that triggers the production of cytotoxic reactive oxygen species (ROS) leading to the killing of the cells. In order to overcome the problem of light penetration in the tissues, different solutions were proposed in the past. The use of radioisotopes like: 18F, 64Cu, 90Y, 177Lu as internal light sources increase the light fluence at the PS compared to an external source, resulting in a larger cytotoxic effect.

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Section: Pdt Using Radioluminescence Lightmentioning

confidence: 99%

Photodynamic Therapy Using Cerenkov and Radioluminescence Light

Spinelli

Boschi

2021

Front. Phys.

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“…2-[ 18 F]-Fluoro-2-deoxy-D-glucose ( 18 F-FDG) was the Cerenkov radioactive source used. In the CLT numerical simulation, Cerenkov photons generated by 18 F radioactive source in tissues were simulated by GEANT4, and the transmission process of these Cerenkov photons in tissues was simulated by MOSE (29)(30)(31)(32).…”

Section: Numerical Simulationsmentioning

confidence: 99%

A Multilevel Probabilistic Cerenkov Luminescence Tomography Reconstruction Framework Based on Energy Distribution Density Region Scaling

Wei

Guo

et al. 2021

Front. Oncol.

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Cerenkov luminescence tomography (CLT) is a promising non-invasive optical imaging method with three-dimensional semiquantitative in vivo imaging capability. However, CLT itself relies on Cerenkov radiation, a low-intensity radiation, making CLT reconstruction more challenging than other imaging modalities. In order to solve the ill-posed inverse problem of CLT imaging, some numerical optimization or regularization methods need to be applied. However, in commonly used methods for solving inverse problems, parameter selection significantly influences the results. Therefore, this paper proposed a probabilistic energy distribution density region scaling (P-EDDRS) framework. In this framework, multiple reconstruction iterations are performed, and the Cerenkov source distribution of each reconstruction is treated as random variables. According to the spatial energy distribution density, the new region of interest (ROI) is solved. The size of the region required for the next operation was determined dynamically by combining the intensity characteristics. In addition, each reconstruction source distribution is given a probability weight value, and the prior probability in the subsequent reconstruction is refreshed. Last, all the reconstruction source distributions are weighted with the corresponding probability weights to get the final Cerenkov source distribution. To evaluate the performance of the P-EDDRS framework in CLT, this article performed numerical simulation, in vivo pseudotumor model mouse experiment, and breast cancer mouse experiment. Experimental results show that this reconstruction framework has better positioning accuracy and shape recovery ability and can optimize the reconstruction effect of multiple algorithms on CLT.

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“…Cerenkov radiation has attracted a considerable amount of recent research interest for its potential applications in life sciences and engineering, such as in molecular imaging, [35][36][37][38][39][40][41][42][43][44][45][46][47][48] particle detection, [49][50][51][52][53] ionizing radiation quality assurance, and beam monitoring. [54][55][56][57][58] Cerenkov radiation is a visible light emitted from a dielectric medium when charged particles with velocities greater than the phase velocity of the light in that medium, i.e., v > c∕n, pass through it.…”

Section: čErenkov Radiatioňmentioning

confidence: 99%

Radiotherapy fiber dosimeter probes based on silver-only coated hollow glass waveguides

et al. 2018

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Manifestation of Čerenkov radiation as a contaminating signal is a significant issue in radiation therapy dose measurement by fiber-coupled scintillator dosimeters. To enhance the scintillation signal transmission while minimizing Čerenkov radiation contamination, we designed a fiber probe using a silver-only coated hollow waveguide (HWG). The HWG with scintillator inserted in its tip, embedded in tissue-mimicking phantoms, was irradiated with clinical electron and photon beams generated by a medical linear accelerator. Optical spectra of the irradiated tip were taken using a fiber spectrometer, and the signal was deconvolved with a linear fitting algorithm. The resultant decomposed spectra of the scintillator with and without Čerenkov correction were in agreement with measurements performed by a standard electron diode and ion chamber for electron and photon beam dosimetry, respectively, indicating the minimal effect of Čerenkov contamination in the HWG-based dosimeter. Furthermore, compared with a silver/dielectric-coated HWG fiber dosimeter design, we observed higher signal transmission in the design based on the use of silver-only HWG.

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Monte Carlo simulations support non-Cerenkov radioluminescence production in tissue

Cited by 4 publications

References 52 publications

Photodynamic Therapy Using Cerenkov and Radioluminescence Light

Photodynamic Therapy Using Cerenkov and Radioluminescence Light

A Multilevel Probabilistic Cerenkov Luminescence Tomography Reconstruction Framework Based on Energy Distribution Density Region Scaling

Radiotherapy fiber dosimeter probes based on silver-only coated hollow glass waveguides

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