Montelukast ameliorates streptozotocin-induced cognitive impairment and neurotoxicity in mice

Zhang, Chun Teng; Lin, Jingran; Wu, Feng; Ghosh, Arijit; Tang, Su Su; Mei, Hu; Long, Yan; Sun, Hui; Hong, Hao

doi:10.1016/j.neuro.2016.09.022

Cited by 27 publications

(20 citation statements)

References 58 publications

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“…On day 3, day 4 and day 5, the hidden‐platform test was performed to determine the retention of memory and assess the spatial learning. The probe trial was conducted on day 6 . The swimming speed, latency, time spent in the target quadrant and the number of target crossings were recorded and handled by the analysis‐management system (Viewer Tracking Software, Ji Liang Instruments, Shanghai, China).…”

Section: Methodsmentioning

confidence: 99%

“…Y‐maze test was operated similar as our own previously described . The first day, each mouse was permitted to explore freely for 5 min to adapt the new circumstance.…”

Section: Methodsmentioning

confidence: 99%

“…The PVDF membrane was washed with TBST and incubated with the secondary antibody (horseradish peroxidase). The enhanced chemiluminescence detection reagents were used to visualize the antibody‐reactive bands . Protein was normalized to Histone H3 (NF‐κB p65) or β‐actin (TNF‐α, IL‐1β, IL‐6, caspase‐3, Bax and Bcl‐2) levels.…”

Section: Methodsmentioning

confidence: 99%

“…The probe trial was conducted on day 6. [20,21] The swimming speed, latency, time spent in the target quadrant and the number of target crossings were recorded and handled by the analysis-management system (Viewer Tracking Software, Ji Liang Instruments, Shanghai, China).…”

Section: Morris Water Maze Testmentioning

confidence: 99%

“…Y-maze test was operated similar as our own previously described. [21,22] The first day, each mouse was permitted to explore freely for 5 min to adapt the new circumstance. Through the rods of the two compartments, electric shocks (10 V, 2 Hz, 125 ms) were started.…”

Section: Y-maze Testmentioning

confidence: 99%

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Neuroprotective effect of mogrol against Aβ1–42-induced memory impairment neuroinflammation and apoptosis in mice

Chen

Liu

Meng

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Cognitive impairment is the main character of Alzheimer's disease (AD). This study mainly focused on whether mogrol, a tetracyclic triterpenoids compound of Siraitia grosvenorii Swingle, can ameliorate the memory impairment induced by Aβ1–42. Methods Memory impairment mice model was made by stereotactic intra‐hippocampal microinjection of Aβ1–42 (410 pm/mouse). Mogrol (20, 40, 80 mg/kg) was given to mice by intragastric administration at 3 days after Aβ1–42 injection for totally 3 weeks. Morris water maze test and Y‐maze test were operated to evaluate the therapeutic effect of morgrol on Aβ1–42‐induced memory impairments. Immunohistochemical analyses and Hoechst 33258 assay were used to evaluate effect of morgrol on Aβ1–42‐induced microglia overactivation and apoptotic response in hippocampus of mice. Western blotting assay was used to evaluate effect of mogrol on the Aβ1–42‐activated NF‐κB signaling. Key findings Mogrol could significantly alleviate Aβ1–42‐induced memory impairments, inhibit Aβ1–42‐induced microglia overactivation and prevent Aβ1–42‐triggered apoptotic response in the hippocampus. Mogrol also could suppress Aβ1–42‐activated NF‐κB signaling, reduce the production of proinflammatory cytokines. Conclusions This study suggested that mogrol would ameliorate the memory impairment induced by Aβ1–42, which is involved in anti‐inflammation and anti‐apoptosis in the brain.

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Section: Methodsmentioning

confidence: 99%

“…Y‐maze test was operated similar as our own previously described . The first day, each mouse was permitted to explore freely for 5 min to adapt the new circumstance.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Morris Water Maze Testmentioning

confidence: 99%

Section: Y-maze Testmentioning

confidence: 99%

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